{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T17:38:54Z","timestamp":1775756334138,"version":"3.50.1"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,10,3]]},"abstract":"\n Background<\/jats:title>\n \n Contemporary rates of oral anticoagulant (\n OAC<\/jats:styled-content>\n ) therapy and associated outcomes among patients undergoing percutaneous coronary intervention (\n PCI<\/jats:styled-content>\n ) have been poorly described.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Using data from an integrated health care system from 2009 to 2014, we identified patients on\n OAC<\/jats:styled-content>\n s within 30\u00a0days of\n PCI<\/jats:styled-content>\n . Outcomes included in\u2010hospital bleeding and mortality. Of 9566\n PCI<\/jats:styled-content>\n s, 837 patients (8.8%) were on\n OAC<\/jats:styled-content>\n s, and of these, 7.9% used non\u2013vitamin K antagonist agents.\n OAC<\/jats:styled-content>\n use remained stable during the study (8.1% in 2009, 9.0% in 2014;\n P<\/jats:italic>\n =0.11), whereas use of non\u2013vitamin K antagonist agents in those on\n OAC<\/jats:styled-content>\n s increased (0% in 2009, 16% in 2014;\n P<\/jats:italic>\n <0.01). Following\n PCI<\/jats:styled-content>\n ,\n OAC<\/jats:styled-content>\n \u2010treated patients had higher crude rates of major bleeding (11% versus 6.5%;\n P<\/jats:italic>\n <0.01), access\u2010site bleeding (2.3% versus 1.3%;\n P<\/jats:italic>\n =0.017), and non\u2013access\u2010site bleeding (8.2% versus 5.2%;\n P<\/jats:italic>\n <0.01) but similar crude rates of in\u2010hospital stent thrombosis (0.4% versus 0.3%;\n P<\/jats:italic>\n =0.85), myocardial infarction (2.5% versus 3.0%;\n P<\/jats:italic>\n =0.40), and stroke (0.48% versus 0.52%;\n P<\/jats:italic>\n =0.88). In addition, prior to adjustment,\n OAC<\/jats:styled-content>\n \u2010treated patients had longer hospitalizations (3.9\u00b15.5\u00a0versus 2.8\u00b14.6\u00a0days;\n P<\/jats:italic>\n <0.01), more transfusions (7.2% versus 4.2%;\n P<\/jats:italic>\n <0.01), and higher 90\u2010day readmission rates (22.1% versus 13.1%;\n P<\/jats:italic>\n <0.01). In adjusted models,\n OAC<\/jats:styled-content>\n use was associated with increased risks of in\u2010hospital bleeding (odds ratio 1.50;\n P<\/jats:italic>\n <0.01), 90\u2010day readmission (odds ratio 1.40;\n P<\/jats:italic>\n <0.01), and long\u2010term mortality (hazard ratio 1.36;\n P<\/jats:italic>\n <0.01).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Chronic\n OAC<\/jats:styled-content>\n therapy is frequent among contemporary patients undergoing\n PCI<\/jats:styled-content>\n . After adjustment for potential confounders,\n OAC<\/jats:styled-content>\n \u2010treated patients experienced greater in\u2010hospital bleeding, more readmissions, and decreased long\u2010term survival following\n PCI<\/jats:styled-content>\n . Efforts are needed to reduce the occurrence of adverse events in this population.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.116.004310","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T20:15:06Z","timestamp":1476821706000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Use of Chronic Oral Anticoagulation and Associated Outcomes Among Patients Undergoing Percutaneous Coronary Intervention"],"prefix":"10.1161","volume":"5","author":[{"given":"Eric A.","family":"Secemsky","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA"},{"name":"Harvard Medical School, Boston, MA"},{"name":"Smith Center for Outcomes Research in Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neel M.","family":"Butala","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, MA"},{"name":"Department of Medicine, Massachusetts General Hospital, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uri","family":"Kartoun","sequence":"additional","affiliation":[{"name":"Center for Systems Biology and Center for Assessment Technology & Continuous Health (CATCH), Massachusetts General Hospital, Boston, MA"},{"name":"Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadiqa","family":"Mahmood","sequence":"additional","affiliation":[{"name":"Department of Quality, Safety and Value, Partners HealthCare, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason H.","family":"Wasfy","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA"},{"name":"Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin F.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Saint Luke's Mid\u2010America Heart Institute, Kansas City, MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley Y.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA"},{"name":"Center for Systems Biology and Center for Assessment Technology & Continuous Health (CATCH), Massachusetts General Hospital, Boston, MA"},{"name":"Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Yeh","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, MA"},{"name":"Smith Center for Outcomes Research in Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.11.012"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2011.02.011"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2010.10.011"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.1556"},{"key":"e_1_3_4_6_2","first-page":"170","article-title":"In\u2010hospital management and outcome of patients on warfarin undergoing coronary stent implantation: results of the multicenter, prospective WARfarin and coronary STENTing (WAR\u2010STENT) registry","volume":"25","author":"Rubboli A","year":"2013","unstructured":"Rubboli A, Sciahbasi A, Briguori C, Saia F, Palmieri C, Moroni LA, Calabro P, Leone AM, Franco N, Valgimigli M, Varani E, Santi M, Pasqualini P, Capecchi A, Piccalo G, Margheri M, di Pasquale G, Galvani M, Bolognese L, Gonzini L, Maggioni AP. 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