{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:05:46Z","timestamp":1789923946221,"version":"4.0.1"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,1,11]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Women hospitalized with a non\u2010\n              <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\n              segment elevation acute coronary syndrome (\n              <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>\n              ) have worse clinical outcomes compared with men. An early invasive strategy with prompt coronary revascularization may mitigate sex differences in outcomes. However, few contemporary studies have evaluated whether clinical outcomes differ between women and men presenting with\n              <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>\n              treated with an early invasive strategy.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A population\u2010based cohort of hospitalized\n              <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>\n              patients who received prompt cardiac catheterization from 2008 to 2011 in Ontario, Canada and followed for up to 2\u00a0years was studied. Clinical outcomes were compared between men and women, stratified by the use of coronary revascularization. Inverse probability weighting using the propensity score accounted for measured differences in baseline characteristics between men and women. Among the 23\u00a0473\n              <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>\n              patients who received cardiac catheterization during an index hospitalization, 66.1% of men and 51.8% of women received coronary revascularization during the same hospitalization. In the propensity\u2010weighted cohort of patients who received coronary revascularization, the 1\u2010year rate of death or recurrent\n              <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>\n              was 10.6% for men (referent) compared with 13.1% for women (hazard ratio 1.24; 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              1.16\u20131.33). In contrast, outcomes for patients who did not receive coronary revascularization did not differ significantly between women and men at 1\u00a0year (17.8% versus 16.9%; hazard ratio 1.06; 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              0.99\u20131.14) or at longer follow\u2010up.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              An increased risk of adverse clinical outcomes was observed for women with\n              <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>\n              undergoing an early invasive strategy and coronary revascularization compared with men.\n            <\/jats:p>\n          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University of Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshay","family":"Bagai","sequence":"additional","affiliation":[{"name":"Terrence Donnelly Heart Center, St. Michael's Hospital, University of Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T.","family":"Yan","sequence":"additional","affiliation":[{"name":"Terrence Donnelly Heart Center, St. Michael's Hospital, University of Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun G.","family":"Goodman","sequence":"additional","affiliation":[{"name":"Terrence Donnelly Heart Center, St. Michael's Hospital, University of Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack V.","family":"Tu","sequence":"additional","affiliation":[{"name":"Institute for Clinical Evaluative Sciences, University of Toronto, Ontario, Canada"},{"name":"Department of Medicine, 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