{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T10:35:19Z","timestamp":1763116519882,"version":"3.41.2"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,10,3]]},"abstract":"\n Background<\/jats:title>\n \n Percutaneous pulmonary valve implantation (\n PPVI<\/jats:styled-content>\n ) is first\u2010line therapy for some congenital heart disease patients with right ventricular outflow tract dysfunction. The hemodynamics improvements after\n PPVI<\/jats:styled-content>\n are well documented, but little is known about its effects on the electrophysiologic substrate. The objective of this study is to assess the short\u2010 and medium\u2010term electrophysiologic substrate changes and elucidate postprocedure arrhythmias.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n A retrospective chart review of patients undergoing\n PPVI<\/jats:styled-content>\n from May 2010 to April 2015 was performed. A\u00a0total of 106 patients underwent\n PPVI<\/jats:styled-content>\n ; most commonly these patients had tetralogy of Fallot (n=59, 55%) and pulmonary insufficiency (n=60, 57%). The median follow\u2010up time was 28\u00a0months (7\u201063\u00a0months). Pre\u2010\n PPVI<\/jats:styled-content>\n , 25 patients (24%) had documented arrhythmias: nonsustained ventricular tachycardia (\n NSVT<\/jats:styled-content>\n ) (n=9, 8%), frequent premature ventricular contractions (\n PVC<\/jats:styled-content>\n s) (n=6, 6%), and atrial fibrillation\/flutter (\n AF<\/jats:styled-content>\n \/\n AFL<\/jats:styled-content>\n ) (n=10, 9%). Post\u2010\n PPVI<\/jats:styled-content>\n , arrhythmias resolved in 4 patients who had\n NSVT<\/jats:styled-content>\n (44%) and 5 patients who had\n PVC<\/jats:styled-content>\n s (83%). New arrhythmias were seen in 16 patients (15%): 7\n NSVT<\/jats:styled-content>\n , 8\n PVC<\/jats:styled-content>\n s, and 1\n AF<\/jats:styled-content>\n \/\n AFL<\/jats:styled-content>\n . There was resolution at medium\u2010term follow\u2010up in 6 (86%) patients with new\u2010onset\n NSVT<\/jats:styled-content>\n and 7 (88%) patients with new\u2010onset\n PVC<\/jats:styled-content>\n s. There was no difference in\n QRS<\/jats:styled-content>\n duration pre\u2010\n PPVI<\/jats:styled-content>\n , post\u2010\n PPVI<\/jats:styled-content>\n , and at medium\u2010term follow\u2010up (\n P<\/jats:italic>\n =0.6). The median corrected\n QT<\/jats:styled-content>\n lengthened immediately post\u2010\n PPVI<\/jats:styled-content>\n but shortened significantly at midterm follow\u2010up (\n P<\/jats:italic>\n <0.01).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n PPVI<\/jats:styled-content>\n reduced the prevalence of\n NSVT<\/jats:styled-content>\n . The majority of postimplant arrhythmias resolve by 6\u00a0months of follow\u2010up.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.116.004325","type":"journal-article","created":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T02:39:52Z","timestamp":1475289592000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Percutaneous Pulmonary Valve Implantation Alters Electrophysiologic Substrate"],"prefix":"10.1161","volume":"5","author":[{"given":"Hoang H.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shabana","family":"Shahanavaz","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George F.","family":"Van Hare","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David T.","family":"Balzer","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramzi","family":"Nicolas","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO"},{"name":"Division of Cardiology, Department of Pediatrics, Southern Illinois University, Springfield, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer N.","family":"Avari 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