{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:54:55Z","timestamp":1787018095970,"version":"build-2736575974"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Prolonged\n                      <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content>\n                      duration is associated with increased mortality among heart failure patients, but race or sex differences in\n                      <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content>\n                      duration and associated effect on outcomes are unknown.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We investigated\n                      <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content>\n                      duration and morphology among 2463 black and white patients with heart failure and left ventricular ejection fraction \u226435% who underwent coronary angiography and 12\u2010lead electrocardiography at Duke University Hospital from 1995 through 2011. We used multivariable Cox regression models to assess the relationship between\n                      <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content>\n                      duration and all\u2010cause mortality and investigate race\u2010\n                      <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content>\n                      and sex\u2010\n                      <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content>\n                      duration interaction. Median\n                      <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content>\n                      duration was 105\u00a0ms (interquartile range [\n                      <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                      ], 92\u2013132) with variation by race and sex (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001).\n                      <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content>\n                      duration was longest in white men (111\u00a0ms;\n                      <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                      , 98\u2013139) followed by white women (108\u00a0ms;\n                      <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                      , 92\u2013140), black men (100\u00a0ms;\n                      <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                      , 91\u2013120), and black women (94\u00a0ms;\n                      <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                      , 86\u2013118). Left bundle branch block was more common in women than men (24% vs 14%) and in white (21%) versus black individuals (12%). In black patients, there was a 16% increase in risk of mortality for every 10 ms increase in\n                      <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content>\n                      duration up to 112\u00a0ms (hazard ratio, 1.16; 95% CI, 1.07, 1.25) that was not present among white patients (interaction,\n                      <jats:italic>P<\/jats:italic>\n                      =0.06).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Black individuals with heart failure had a shorter\n                      <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content>\n                      duration and more often had non\u2010\n                      <jats:styled-content style=\"fixed-case\">left bundle branch block<\/jats:styled-content>\n                      morphology than white patients. Women had\n                      <jats:styled-content style=\"fixed-case\">left bundle branch block<\/jats:styled-content>\n                      more commonly than men. Among black patients, modest\n                      <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content>\n                      prolongation was associated with increased mortality.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.116.004381","type":"journal-article","created":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T20:10:37Z","timestamp":1490040637000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Race and Sex Differences in QRS Interval and Associated Outcome Among Patients with Left Ventricular Systolic Dysfunction"],"prefix":"10.1161","volume":"6","author":[{"given":"Tiffany C.","family":"Randolph","sequence":"first","affiliation":[{"name":"Duke Clinical Research Institute Durham NC"},{"name":"Department of Medicine Duke University School of Medicine Durham 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