{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:28:27Z","timestamp":1769599707181,"version":"3.49.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,3]]},"abstract":"\n Background<\/jats:title>\n \n Frequent ventricular premature complexes (\n VPC<\/jats:styled-content>\n s) can lead to the development of dilated cardiomyopathy and sudden cardiac death. Renal artery sympathetic denervation (\n RDN<\/jats:styled-content>\n ) may protect the heart from remodeling. This study aimed to investigate the effect of frequent\n VPC<\/jats:styled-content>\n s on structural and electrical properties and whether\n RDN<\/jats:styled-content>\n can protect the heart from remodeling.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Eighteen rabbits were randomized to control (n=6),\n VPC<\/jats:styled-content>\n (n=6), and\n VPC<\/jats:styled-content>\n \u2010\n RDN<\/jats:styled-content>\n (n=6) groups. Surgical and chemical\n RDN<\/jats:styled-content>\n s were approached through bilateral retroperitoneal flank incisions in the\n VPC<\/jats:styled-content>\n \u2010\n RDN<\/jats:styled-content>\n group. Pacemakers were implanted to the left ventricular apex to produce 50%\n VPC<\/jats:styled-content>\n burden for 5\u00a0weeks in the\n VPC<\/jats:styled-content>\n and\n VPC<\/jats:styled-content>\n \u2010\n RDN<\/jats:styled-content>\n groups. In addition, ventricular myocardium was harvested for western blot and trichrome stain. Echocardiographic results showed left ventricular enlargement after 5\u2010week pacing in the\n VPC<\/jats:styled-content>\n group, but not in the\n VPC<\/jats:styled-content>\n \u2010\n RDN<\/jats:styled-content>\n group, when compared to baseline. In biventricles, ion channel protein expressions of Nav1.5, Cav1.2, Kir2.1, and\n SERCA<\/jats:styled-content>\n 2 were similar among 3 groups. However, the degree of biventricular fibrosis was extensive in the\n VPC<\/jats:styled-content>\n group, compared to the control and\n VPC<\/jats:styled-content>\n \u2010\n RDN<\/jats:styled-content>\n groups. Importantly, ventricular fibrillation inducibility was higher in the\n VPC<\/jats:styled-content>\n group (41%) when comparing to the control (13%;\n P<\/jats:italic>\n <0.05) and\n VPC<\/jats:styled-content>\n \u2010\n RDN<\/jats:styled-content>\n groups (13%;\n P<\/jats:italic>\n <0.05), respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Frequent\n VPC<\/jats:styled-content>\n s are associated with the development of cardiac structural remodeling and high ventricular fibrillation inducibility.\n RDN<\/jats:styled-content>\n prevents cardiac remodeling and the occurrence of ventricular arrhythmia through antifibrosis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.116.004479","type":"journal-article","created":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T02:10:51Z","timestamp":1488507051000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["Beneficial Effect of Renal Denervation on Ventricular Premature Complex Induced Cardiomyopathy"],"prefix":"10.1161","volume":"6","author":[{"given":"Shinya","family":"Yamada","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei City Taiwan, R.O.C."},{"name":"Department of Cardiovascular Medicine Fukushima Medical University Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Wei","family":"Lo","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei City Taiwan, R.O.C."},{"name":"Institute of Clinical Medicine, and Cardiovascular Research Institute National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Hui","family":"Chou","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei City Taiwan, 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