{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:13:59Z","timestamp":1792077239247,"version":"4.4.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,1,11]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Emergent myocardial reperfusion via primary percutaneous coronary intervention is optimal care for patients presenting with\n              <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\n              \u2010segment elevation myocardial infarction (\n              <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>\n              ). Delays in such interventions are associated with increases in mortality. With the shift in focus to contact\u2010to\u2010device (C2D) time as a new perfusion metric, this study was designed to examine how sex affects C2D time and mortality in\n              <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>\n              patients.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Clinical data on male and female\n              <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>\n              patients were extracted and analyzed from the National Cardiovascular Data Registry from July 1, 2008 to December 31, 2014. A total of 102\u00a0515 patients were included in the final analytic cohort. The median C2D time in female patients with\n              <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>\n              was delayed when compared to male patients (80 [65\u201397] versus 75 [61\u201390] minutes;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). The unadjusted mortality was higher in female patients when compared to male patients with\n              <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>\n              (4.1% versus 2.0%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). For every 5\u2010minute increase in C2D time, the adjusted odds ratio for mortality was 1.04 (95%\n              <jats:styled-content style=\"fixed-case\">CI,<\/jats:styled-content>\n              1.03\u20131.06) for female patients with\n              <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>\n              and 1.07 (95% CI, 1.06\u20131.09) for male patients (\n              <jats:italic>P<\/jats:italic>\n              for sex by C2D interaction=0.003).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              To date, this is the largest analysis of\n              <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>\n              patients that measures the impact of the new recommended C2D reperfusion metric on in\u2010hospital mortality. Female\n              <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>\n              patients have longer C2D times and increased mortality. The disparity can be improved and survival can increase in this high\u2010risk patient cohort by decreasing systems issues that cause increased reperfusion times in female\n              <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>\n              patients.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.116.004521","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T02:42:16Z","timestamp":1484188936000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":54,"title":["Impact of Sex and Contact\u2010to\u2010Device Time on Clinical Outcomes in Acute ST\u2010Segment Elevation Myocardial Infarction\u2014Findings From the National Cardiovascular Data Registry"],"prefix":"10.1161","volume":"6","author":[{"given":"Robert O.","family":"Roswell","sequence":"first","affiliation":[{"name":"Department of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Kunkes","sequence":"additional","affiliation":[{"name":"Department of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita Y.","family":"Chen","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Chiswell","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohah","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"Roe","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sripal","family":"Bangalore","sequence":"additional","affiliation":[{"name":"Department of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182742c84"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2010.09.002"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.10.015"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1553-7250(09)35012-6"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2007.10.006"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.01.010"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22278"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208200"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.10.028"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2014.04.005"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/2048872612454021"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.789800"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.3810\/hp.2013.04.1023"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.113.000396"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/1741826711400511"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.200261"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.108.847145"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.2307\/2531248"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.10.004"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.84.2.137"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.2001.tb01282.x"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000117292.19349.D0"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.09.016"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2010.08.003"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.002345"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/joic.12195"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2008.11.013"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.116.004521","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:44:34Z","timestamp":1715597074000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.116.004521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,11]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1,11]]}},"alternative-id":["10.1161\/JAHA.116.004521"],"URL":"https:\/\/doi.org\/10.1161\/jaha.116.004521","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,11]]},"assertion":[{"value":"2016-10-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-12-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e004521"}}