{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T10:18:34Z","timestamp":1791454714278,"version":"4.3.3"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,10,26]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Human cartilage glycoprotein\u201039 (YKL\u201040) has been suggested to be a new marker of inflammation, atherosclerosis, and endothelial dysfunction. However, whether a higher level of YKL\u201040 is an independent risk factor for hypertension incidence is still unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In a nested case\u2010control study within a prospective cohort of 12\u00a0423 initially healthy Chinese adults, we measured baseline plasma concentrations of YKL\u201040 among 700 new\u2010onset hypertension cases and 700 age\u2010 and sex\u2010matched controls. Multiple conditional logistic regression analyses were used to calculate the odds ratios (95% CIs) of hypertension associated with higher levels of YKL\u201040 both in the total population and in the age\u2010 (&gt;55 and \u226455 years) and sex\u2010matched subgroups. Among the total population, YKL\u201040 levels were not associated with hypertension risk. In the subgroup older than 55\u00a0years, odds ratios (95% CIs) of hypertension for those in the two higher tertiles of YKL\u201040 were 1.23 (0.77\u20131.97) and 1.59 (0.99\u20132.55) (\n              <jats:italic>P<\/jats:italic>\n              for linear trend=0.05). In the male subgroup, odds ratios (95% CIs) of hypertension for those in the two higher tertiles of YKL\u201040 were 1.55 (0.88\u20132.72) and 2.09 (1.14\u20133.82) (\n              <jats:italic>P<\/jats:italic>\n              for linear trend=0.02). An interaction effect was observed between YKL\u201040 and sex (\n              <jats:italic>P<\/jats:italic>\n              for interaction &lt;0.01) but not between YKL\u201040 and age (\n              <jats:italic>P<\/jats:italic>\n              for interaction=0.21). High YKL\u201040 level significantly increased hypertension risk in men but decreased hypertension risk with a trend although not significant in women.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">This study suggests that YKL\u201040 is associated with hypertension incidence only among men. The study findings need to be further verified by prospective cohort studies or clinical trials.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.116.004534","type":"journal-article","created":{"date-parts":[[2016,11,5]],"date-time":"2016-11-05T02:19:14Z","timestamp":1478312354000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["YKL\u201040 Level and Hypertension Incidence: A Population\u2010Based Nested Case\u2010Control Study in China"],"prefix":"10.1161","volume":"5","author":[{"given":"Tian","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Neurology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongke","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aili","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhirong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Bu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yipeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfan","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinfeng","family":"HuangFu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengbao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60655-8"},{"key":"e_1_3_3_3_2","unstructured":"World Health Organization . 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Dan Med Bull. 2006;53:172\u2013209.","journal-title":"Dan Med Bull"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1997.4778"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00034409"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-006-0076-y"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.000897"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-12-35"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/10641963.2015.1013122"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365510050184886"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2929"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-6175.2006.05835.x"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(96)00597-8"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/2047487312444234"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90305-0"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2005.06.002"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/174182670100800512"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(98)70016-3"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-3623(02)00131-3"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511421200"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.300156"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/89.2.315"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.116.004534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:21:24Z","timestamp":1715595684000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.116.004534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,26]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,10,26]]}},"alternative-id":["10.1161\/JAHA.116.004534"],"URL":"https:\/\/doi.org\/10.1161\/jaha.116.004534","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,26]]},"assertion":[{"value":"2016-08-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e004534"}}