{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:16:56Z","timestamp":1792700216002,"version":"4.5.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,2,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Cardiovascular morbidity and mortality was reduced by 25% when blood pressure (\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              ) was targeted to 120\u00a0mm\u00a0Hg systolic compared with 140\u00a0mm\u00a0Hg systolic in Systolic Blood Pressure Intervention Trial (SPRINT); however,\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              was measured using a research technique.\n              <jats:styled-content style=\"fixed-case\">SPRINT<\/jats:styled-content>\n              specified 5\u00a0minutes of seated rest in a quiet room followed by 3 oscillometric measurements without an observer in the room. The relationship of this research\u2010grade methodology to routine\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              measurements is not known.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Among 275 people with chronic kidney disease who had\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              &lt;140\/90\u00a0mm\u00a0Hg when they came to the clinic, we measured\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              as in\n              <jats:styled-content style=\"fixed-case\">SPRINT<\/jats:styled-content>\n              and recorded\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              on the same day without specification of seated rest. Compared with routine measurement, the research\u2010grade systolic\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              was 12.7\u00a0mm\u00a0Hg lower with wide limits of agreement (\u221246.1 to 20.7\u00a0mm\u00a0Hg). Research grade systolic\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              was 7.9\u00a0mm\u00a0Hg lower than daytime ambulatory systolic\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              and had wide agreement limits (\u221233.2 to 17.4\u00a0mm\u00a0Hg). Whereas the routine, research\u2010grade, and daytime ambulatory systolic\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              were all related to echocardiographic left ventricular hypertrophy, the strength of the relationship between research\u2010grade and daytime ambulatory systolic\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              to left\u00a0ventricular hypertrophy was similar and stronger than the strength of the relationship between routine systolic\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              and left ventricular hypertrophy.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Taken together, these results suggest that translation of the\n              <jats:styled-content style=\"fixed-case\">SPRINT<\/jats:styled-content>\n              results will require measurement of\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              as performed in that trial. Instead of an algebraic manipulation of routine clinic measurements, the\n              <jats:styled-content style=\"fixed-case\">SPRINT<\/jats:styled-content>\n              methodology of\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              measurement would be needed at minimum if implementation of the\n              <jats:styled-content style=\"fixed-case\">SPRINT<\/jats:styled-content>\n              results were to be deployed in the population at large.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.116.004536","type":"journal-article","created":{"date-parts":[[2017,2,4]],"date-time":"2017-02-04T01:10:44Z","timestamp":1486170644000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":121,"title":["Implications of Blood Pressure Measurement Technique for Implementation of Systolic Blood Pressure Intervention Trial (SPRINT)"],"prefix":"10.1161","volume":"6","author":[{"given":"Rajiv","family":"Agarwal","sequence":"first","affiliation":[{"name":"Indiana University School of Medicine and Richard L. 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J Am Soc Hypertens. 2011;5:484\u2013488.","journal-title":"J Am Soc Hypertens"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3283577b05"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001286"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60852-1"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/MBP.0b013e3280858d5b"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.116.004536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:55:22Z","timestamp":1715597722000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.116.004536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,2]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2,2]]}},"alternative-id":["10.1161\/JAHA.116.004536"],"URL":"https:\/\/doi.org\/10.1161\/jaha.116.004536","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,2]]},"assertion":[{"value":"2016-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-12-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e004536"}}