{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:00:36Z","timestamp":1784869236779,"version":"3.55.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,2,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">This study aimed to demonstrate the feasibility of measuring frailty in patients with cardiac implantable electrical devices while validating the physiologic significance of device\u2010detected physical activity by evaluating its association with frailty and mobility.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Outpatients with cardiac implantable electrical devices compatible with physical activity analysis with at least 7\u00a0days of data were eligible. Office testing included frailty status (Study of Osteoporotic Fractures instrument), gait speed (m\/s), mobility according to the Timed Up and Go (\n              <jats:styled-content style=\"fixed-case\">TUG<\/jats:styled-content>\n              ) test (seconds), and daily physical activity (h\/d) as measured by cardiac implantable electrical device. Among 219 patients, Study of Osteoporotic Fractures testing found 39.7% to be robust, 47.5% prefrail, and 12.8% frail. The mean gait speed for the cohort was 0.8\u00b10.3\u00a0m\/s, mean\n              <jats:styled-content style=\"fixed-case\">TUG<\/jats:styled-content>\n              time was 10.9\u00b14.4\u00a0seconds, and mean activity was 2.8\u00b11.9\u00a0h\/d. Frail patients were markedly more likely to have gait speeds &lt;0.8\u00a0m\/s (\n              <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n              6.25, 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              1.79\u201033.3). In unadjusted analyses each 1\u2010hour increase in mean daily activity was associated with a 46% reduction of frail phenotype (\n              <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n              0.54, 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              0.40\u20100.74) versus robust and with a 27% reduction in the odds of having the prefrail phenotype (\n              <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n              0.73, 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              0.62\u20100.86). After adjustment this association per hour of activity persisted, with an adjusted\n              <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n              for frailty of 0.71 (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              0.51\u20100.99) and adjusted\n              <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n              for prefrailty of 0.81 (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              0.67\u20100.99).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Frailty and mobility limitation are common among cardiac implantable electrical device patients and are correlated to device\u2010detected physical activity.<\/jats:p>\n          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