{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:13:12Z","timestamp":1790691192865,"version":"4.1.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec id=\"jah31916-sec-0001\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Cyanate has recently gained attention for its role in the pathogenesis of vascular injury. Nonetheless, the effect of cyanate on angiogenesis remains unclear.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah31916-sec-0002\" xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In this study, we demonstrated that oral administration of cyanate impaired blood perfusion recovery in a mouse hind\u2010limb ischemia model. A reduction in blood perfusion recovery at day 21 was observed in the ischemic tissue of cyanate\u2010treated mice. Likewise, there were fewer capillaries in the ischemic hind\u2010limb tissue of cyanate\u2010exposed mice. Our in\u00a0vitro study showed that cyanate, together with its carbamylated products, inhibited the migration, proliferation, and tube\u2010formation abilities of endothelial cells. Further research revealed that cyanate regulated angiogenesis partly by interrupting the vascular endothelial growth factor receptor 2\/phosphatidylinositol 3\u2010kinase\/Akt pathway. The serum concentrations of homocitrulline, a marker of cyanate exposure, were determined in 117 patients with stable angina and chronic total occlusion. Consistent with the antiangiogenic role of cyanate, homocitrulline levels were increased in patients with poor coronary collateralization (n=58) compared with those with high collateralization (n=59; 21.09\u00b113.08\u00a0versus 15.54\u00b19.02\u00a0ng\/mL,\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.009). In addition, elevated homocitrulline concentration was a strong predictor of poor coronary collateral growth.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah31916-sec-0003\" xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Impaired angiogenesis induced by cyanate might contribute to poor coronary collateral growth.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.116.004700","type":"journal-article","created":{"date-parts":[[2016,12,17]],"date-time":"2016-12-17T02:15:24Z","timestamp":1481940924000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Cyanate\u2010Impaired Angiogenesis: Association With Poor Coronary Collateral Growth in Patients With Stable Angina and Chronic Total Occlusion"],"prefix":"10.1161","volume":"5","author":[{"given":"Jia Teng","family":"Sun","sequence":"first","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing Yan","family":"Mao","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei Feng","family":"Shen","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]},{"name":"Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Lu","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi Hong","family":"Wu","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li Ping","family":"Wu","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1089\/ars.2012.4849","article-title":"Angiogenesis in the infarcted myocardium","volume":"18","author":"Cochain C","year":"2013","unstructured":"Cochain C, Channon KM, Silvestre JS. 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