{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:35:41Z","timestamp":1782293741521,"version":"3.54.5"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,11,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">We investigated how body weight affects survival after stroke, leveraging the availability of multiple prestroke body mass index (BMI) measurements and using a nested case\u2010control design in a community\u2010based sample.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We compared all\u2010cause mortality in participants stratified by prestroke weight. Separate analyses were performed for ischemic stroke and all stroke and for age\u2010, sex\u2010, and BMI category\u2010matched stroke\u2010free controls. Participants were grouped into BMI categories and followed for up to 10\u00a0years. Differences in survival were tested for interaction by case status. In sensitivity analysis, to exclude those with prestroke weight loss, we restricted the reference group to participants with 2 consistently normal BMI measurements within 10\u00a0years before stroke\/matching. There were 782 stroke cases (age 71\u00b19, 51% female participants, 87% ischemic stroke) and 2346 controls (age 72\u00b19, 51% female participants). Overweight participants with ischemic stroke had a lower mortality compared with those with normal weight (hazard ratio [HR]=0.70, 95%CI 0.55\u20100.90,\n              <jats:italic>P<\/jats:italic>\n              =0.005). The association of reduced mortality with BMI \u226525, compared with normal\u2010weight BMI 18.5 to &lt;25, was pronounced among ischemic stroke cases but diminished with inclusion of hemorrhagic strokes (case\u2010control interaction\n              <jats:italic>P<\/jats:italic>\n              =0.051 and\n              <jats:italic>P<\/jats:italic>\n              =0.130, respectively). Compared with participants with stable normal weight, moderately increased weight was protective after ischemic stroke (overweight HR=0.72, 95%CI 0.53\u20100.99,\n              <jats:italic>P<\/jats:italic>\n              =0.041).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Overweight and mildly obese participants had better 10\u2010year survival after ischemic stroke compared with normal\u2010weight participants, even after excluding persons with recent prestroke weight loss. There may be unknown protective factors associated with a moderately increased body weight before stroke.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.116.004721","type":"journal-article","created":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T00:10:16Z","timestamp":1498349416000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":36,"title":["Overweight, Obesity, and Survival After Stroke in the Framingham Heart Study"],"prefix":"10.1161","volume":"6","author":[{"given":"Hugo J.","family":"Aparicio","sequence":"first","affiliation":[{"name":"Department of Neurology, School of Medicine, Boston University, Boston, MA"},{"name":"National Heart, Lung, and Blood Institute's Framingham Study, Framingham, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayandra J.","family":"Himali","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, Boston University, Boston, MA"},{"name":"National Heart, Lung, and Blood Institute's Framingham Study, Framingham, MA"},{"name":"Department of Biostatistics, Boston University School of Public Health, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa S.","family":"Beiser","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, Boston University, Boston, MA"},{"name":"National Heart, Lung, and Blood Institute's Framingham Study, Framingham, MA"},{"name":"Department of Biostatistics, Boston University School of Public Health, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendra L.","family":"Davis\u2010Plourde","sequence":"additional","affiliation":[{"name":"National Heart, Lung, and Blood Institute's Framingham Study, Framingham, MA"},{"name":"Department of Biostatistics, Boston University School of Public Health, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramachandran S.","family":"Vasan","sequence":"additional","affiliation":[{"name":"Evans Memorial Medicine Department, School of Medicine, Boston University, Boston, MA"},{"name":"Section\u00a0of Preventive Medicine, School of Medicine, Boston University, Boston, MA"},{"name":"Section\u00a0of Cardiovascular Medicine, School of Medicine, Boston University, Boston, MA"},{"name":"Whitaker Cardiovascular Institute, School of Medicine, Boston University, Boston, MA"},{"name":"National Heart, Lung, and Blood Institute's Framingham Study, Framingham, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos S.","family":"Kase","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, Boston University, Boston, MA"},{"name":"National Heart, Lung, and Blood Institute's Framingham Study, Framingham, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip A.","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, Boston University, Boston, MA"},{"name":"National Heart, Lung, and Blood Institute's Framingham Study, Framingham, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudha","family":"Seshadri","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, Boston University, Boston, MA"},{"name":"National Heart, Lung, and Blood Institute's Framingham Study, Framingham, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000152"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.24.2939"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.22.2557"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60318-4"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000046"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.593434"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318266fad1"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000328250"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.1017"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01448-6"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69251-9"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2013.09.019"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21239"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000199613.38911.b2"},{"key":"e_1_3_5_16_2","first-page":"5","volume-title":"The Framingham Study; An Epidemiological Investigation of Cardiovascular Disease","author":"Abbott RD","year":"1987","unstructured":"Abbott RD, McGee DL. 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