{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:03:01Z","timestamp":1790611381348,"version":"4.1.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Plaque rupture and erosion are the 2 most common mechanisms for acute coronary syndromes. However, the outcome of these 2 distinct pathologies in patients with acute coronary syndromes has never been studied.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We retrospectively studied 141 patients with acute coronary syndromes who underwent optical coherence tomography (\n              <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>\n              ) imaging of the culprit lesion prior to stenting from the Massachusetts General Hospital\n              <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>\n              Registry. Management (stent versus no stent), poststent\n              <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>\n              findings, and outcomes were compared. Among the 141 culprit lesions, rupture was found in 79 (56%) patients and erosion in 62 (44%). Stent implantation was performed in 77 (97.5%) patients with rupture versus 49 (79.0%) in those with erosion (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Immediately after percutaneous coronary intervention,\n              <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>\n              showed a higher incidence of malapposition (37.5% versus 7.3%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), thrombus (59.4% versus 14.6%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), and protrusion (93.8% versus 73.2%,\n              <jats:italic>P<\/jats:italic>\n              =0.008) in the rupture group compared with the erosion group. Plaque rupture was associated with a higher incidence of no reflow or slow flow and distal embolization. Although cardiac event rates were comparable between the two groups at the 1\u2010year follow\u2010up, none of the erosion patients who were treated conservatively without stenting had adverse cardiac events.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Unfavorable poststent\n              <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>\n              findings were more frequent in rupture patients compared with erosion patients. A subset of erosion patients who were treated conservatively without stenting remained free of adverse cardiac events for up to 1\u00a0year.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.116.004730","type":"journal-article","created":{"date-parts":[[2017,2,25]],"date-time":"2017-02-25T02:10:40Z","timestamp":1487988640000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":65,"title":["Management and Outcome of Patients With Acute Coronary Syndrome Caused by Plaque Rupture Versus Plaque Erosion: An\u00a0Intravascular Optical Coherence Tomography Study"],"prefix":"10.1161","volume":"6","author":[{"given":"Sining","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Cardiology The 2nd Affiliated Hospital of Harbin Medical University Harbin China"},{"name":"The Key Laboratory of Myocardial Ischemia Chinese Ministry of Education Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinchun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiology The 2nd Affiliated Hospital of Harbin Medical University Harbin China"},{"name":"The Key Laboratory of Myocardial Ischemia Chinese Ministry of Education Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The 2nd Affiliated Hospital of Harbin Medical University Harbin China"},{"name":"The Key Laboratory of Myocardial Ischemia Chinese Ministry of Education Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiannan","family":"Dai","sequence":"additional","affiliation":[{"name":"Cardiology Division Massachusetts General Hospital Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology The 2nd Affiliated Hospital of Harbin Medical University Harbin China"},{"name":"The Key Laboratory of Myocardial Ischemia Chinese Ministry of Education Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold","family":"Dauerman","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Vermont College of Medicine\/Fletcher Allen Healthcare Burlington VT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsunenari","family":"Soeda","sequence":"additional","affiliation":[{"name":"Nara Medical University Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology Cambridge MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Lee","sequence":"additional","affiliation":[{"name":"Biostatistics Massachusetts General Hospital Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The 2nd Affiliated Hospital of Harbin Medical University Harbin China"},{"name":"The Key Laboratory of Myocardial Ischemia Chinese Ministry of Education Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyang","family":"Zhe","sequence":"additional","affiliation":[{"name":"Department of Cardiology The 2nd Affiliated Hospital of Harbin Medical University Harbin China"},{"name":"The Key Laboratory of Myocardial Ischemia Chinese Ministry of Education Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The 2nd Affiliated Hospital of Harbin Medical University Harbin China"},{"name":"The Key Laboratory of Myocardial Ischemia Chinese Ministry of Education Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonghui","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology The 2nd Affiliated Hospital of Harbin Medical University Harbin China"},{"name":"The Key Laboratory of Myocardial Ischemia Chinese Ministry of Education Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaosong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The 2nd Affiliated Hospital of Harbin Medical University Harbin China"},{"name":"The Key Laboratory of Myocardial Ischemia Chinese Ministry of Education Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Cardiology The 2nd Affiliated Hospital of Harbin Medical University Harbin China"},{"name":"The Key Laboratory of Myocardial Ischemia Chinese Ministry of Education Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiology The 2nd Affiliated Hospital of Harbin Medical University Harbin China"},{"name":"The Key Laboratory of Myocardial Ischemia Chinese Ministry of Education Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ik\u2010Kyung","family":"Jang","sequence":"additional","affiliation":[{"name":"Kyung Hee University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.5.1262"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.071"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.1.71"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200106213442501"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)07349-3"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09894-X"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.762047"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2009.04.016"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.09.007"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61444-5"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067193"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067731"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.112.976167"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.05.027"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.12.007"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.10.024"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.09.079"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2012.06.019"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0000000000000072"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01799-5"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000029927.92825.F6"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.01.061"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.11.025"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs095"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.1.36"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.7.1354"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.02.026"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0507-532"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.82.3.269"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.12.007"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv029"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw381"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.116.004730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:26:55Z","timestamp":1715596015000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.116.004730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1161\/JAHA.116.004730"],"URL":"https:\/\/doi.org\/10.1161\/jaha.116.004730","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"2016-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e004730"}}