{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:51:11Z","timestamp":1789678271010,"version":"4.0.1"},"reference-count":58,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,7]]},"abstract":"\n Background<\/jats:title>\n \n Albuminuria is a marker of inflammation and an independent predictor of cardiovascular morbidity and mortality. The current study evaluated whether eicosapentaenoic acid (\n EPA<\/jats:styled-content>\n ) and docosahexaenoic acid (\n DHA<\/jats:styled-content>\n ) supplementation attenuates progression of albuminuria in subjects with coronary artery disease.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Two\u2010hundred sixty\u2010two subjects with stable coronary artery disease were randomized to either Lovaza (1.86\u00a0g of EPA and 1.5\u00a0g of DHA daily) or no Lovaza (control) for 1\u00a0year. Percent change in urine albumin\u2010to\u2010creatinine ratio (\n ACR<\/jats:styled-content>\n ) was compared. Mean (\n SD<\/jats:styled-content>\n ) age was 63.3 (7.6) years; 17% were women and 30% had type 2 diabetes mellitus. In nondiabetic subjects, no change in urine\n ACR<\/jats:styled-content>\n occurred in either the Lovaza or control groups. In contrast,\n ACR<\/jats:styled-content>\n increased 72.3% (\n P<\/jats:italic>\n <0.001) in diabetic subjects not receiving Lovaza, whereas those receiving Lovaza had no change. In diabetic subjects on an angiotensin\u2010converting enzyme\u2010inhibitor or angiotensin\u2010receptor blocker, those receiving Lovaza had no change in urine\n ACR<\/jats:styled-content>\n , whereas those not receiving Lovaza had a 64.2% increase (\n P<\/jats:italic>\n <0.001). Change in\n ACR<\/jats:styled-content>\n was directly correlated with change in systolic blood pressure (\n r<\/jats:italic>\n =0.394,\n P<\/jats:italic>\n =0.01).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n EPA<\/jats:styled-content>\n and\n DHA<\/jats:styled-content>\n supplementation attenuated progression of albuminuria in subjects with type 2 diabetes mellitus and coronary artery disease, most of whom were on an angiotensin\u2010converting enzyme\u2010inhibitor or angiotensin\u2010receptor blocker. Thus,\n EPA<\/jats:styled-content>\n and\n DHA<\/jats:styled-content>\n supplementation should be considered as additional therapy to an angiotensin\u2010converting enzyme\u2010inhibitor or angiotensin\u2010receptor blocker in subjects with type 2 diabetes mellitus and coronary artery disease.\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n URL<\/jats:styled-content>\n :\n http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n . Unique identifier:\n NCT<\/jats:styled-content>\n 01624727.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.116.004740","type":"journal-article","created":{"date-parts":[[2017,7,15]],"date-time":"2017-07-15T00:10:18Z","timestamp":1500077418000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":43,"title":["Eicosapentaenoic and Docosahexaenoic Acids Attenuate Progression of Albuminuria in Patients With Type 2 Diabetes Mellitus and Coronary Artery Disease"],"prefix":"10.1161","volume":"6","author":[{"given":"Tarec K.","family":"Elajami","sequence":"first","affiliation":[{"name":"Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulhamied","family":"Alfaddagh","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharshan","family":"Lakshminarayan","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Soliman","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhuri","family":"Chandnani","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine K.","family":"Welty","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-015-1121-y"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.07.005"},{"key":"e_1_3_4_4_2","first-page":"247","article-title":"The concomitants of raised blood sugar: studies in newly\u2010detected hyperglycemics II. 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