{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T20:56:13Z","timestamp":1769633773551,"version":"3.49.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,4,5]]},"abstract":"\n Background<\/jats:title>\n Patients with recent non\u2013ST\u2010segment elevation myocardial infarction commonly have heterogeneous characteristics that may be challenging to assess clinically.<\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We prospectively studied the diagnostic accuracy of 2 novel (T1, T2 mapping) and 1 established (T2\u2010weighted short tau inversion recovery [T2W\u2010\n STIR<\/jats:styled-content>\n ]) magnetic resonance imaging methods for imaging the ischemic area at risk and myocardial salvage in 73 patients with non\u2013ST\u2010segment elevation myocardial infarction (mean age 57\u00b110\u00a0years, 78% male) at 3.0\u2010T magnetic resonance imaging within 6.5\u00b13.5\u00a0days of invasive management. The infarct\u2010related territory was identified independently using a combination of angiographic,\n ECG<\/jats:styled-content>\n , and clinical findings. The presence and extent of infarction was assessed with late gadolinium enhancement imaging (gadobutrol, 0.1\u00a0mmol\/kg). The extent of acutely injured myocardium was independently assessed with native T1, T2, and T2W\u2010\n STIR<\/jats:styled-content>\n methods. The mean infarct size was 5.9\u00b18.0% of left ventricular mass. The infarct zone T1 and T2 times were 1323\u00b168 and 57\u00b15\u00a0ms, respectively. The diagnostic accuracies of T1 and T2 mapping for identification of the infarct\u2010related artery were similar (\n P<\/jats:italic>\n =0.125), and both were superior to T2W\u2010\n STIR<\/jats:styled-content>\n (\n P<\/jats:italic>\n <0.001). The extent of myocardial injury (percentage of left ventricular volume) estimated with T1 (15.8\u00b110.6%) and T2 maps (16.0\u00b111.8%) was similar (\n P<\/jats:italic>\n =0.838) and moderately well correlated (\n r<\/jats:italic>\n =0.82,\n P<\/jats:italic>\n <0.001). Mean extent of acute injury estimated with T2W\u2010\n STIR<\/jats:styled-content>\n (7.8\u00b111.6%) was lower than that estimated with T1 (\n P<\/jats:italic>\n <0.001) or T2 maps (\n P<\/jats:italic>\n <0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In patients with non\u2013ST\u2010segment elevation myocardial infarction, T1 and T2 magnetic resonance imaging mapping have higher diagnostic performance than T2W\u2010\n STIR<\/jats:styled-content>\n for identifying the infarct\u2010related artery. Compared with conventional\n STIR<\/jats:styled-content>\n , T1 and T2 maps have superior value to inform diagnosis and revascularization planning in non\u2013ST\u2010segment elevation myocardial infarction.\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n URL<\/jats:styled-content>\n :\n http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n . Unique identifier:\n NCT<\/jats:styled-content>\n 02073422.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.116.004759","type":"journal-article","created":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:25:36Z","timestamp":1491006336000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Diagnostic Accuracy of 3.0\u2010T Magnetic Resonance T1 and T2 Mapping and T2\u2010Weighted Dark\u2010Blood Imaging for the Infarct\u2010Related Coronary Artery in Non\u2013ST\u2010Segment Elevation Myocardial Infarction"],"prefix":"10.1161","volume":"6","author":[{"given":"Jamie","family":"Layland","sequence":"first","affiliation":[{"name":"West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United Kingdom"},{"name":"BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuli","family":"Rauhalammi","sequence":"additional","affiliation":[{"name":"BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew M. Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United Kingdom"},{"name":"BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadeem","family":"Ahmed","sequence":"additional","affiliation":[{"name":"West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United Kingdom"},{"name":"BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaclyn","family":"Carberry","sequence":"additional","affiliation":[{"name":"BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vannesa","family":"Teng Yue May","sequence":"additional","affiliation":[{"name":"BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart","family":"Watkins","sequence":"additional","affiliation":[{"name":"West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christie","family":"McComb","sequence":"additional","affiliation":[{"name":"BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Mangion","sequence":"additional","affiliation":[{"name":"West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United Kingdom"},{"name":"BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"McClure","sequence":"additional","affiliation":[{"name":"BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Carrick","sequence":"additional","affiliation":[{"name":"West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United Kingdom"},{"name":"BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"O'Donnell","sequence":"additional","affiliation":[{"name":"West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arvind","family":"Sood","sequence":"additional","affiliation":[{"name":"Hairmyres Hospital, East Kilbride, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"McEntegart","sequence":"additional","affiliation":[{"name":"West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith G.","family":"Oldroyd","sequence":"additional","affiliation":[{"name":"West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Radjenovic","sequence":"additional","affiliation":[{"name":"BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, 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