{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:15:23Z","timestamp":1792815323849,"version":"4.5.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,4,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Contemporary data on patients presenting with acute limb ischemia (\n              <jats:styled-content style=\"fixed-case\">ALI<\/jats:styled-content>\n              ), who are selected for treatment with endovascular peripheral vascular interventions (\n              <jats:styled-content style=\"fixed-case\">PVI<\/jats:styled-content>\n              ), are limited. Our study examined outcomes following endovascular\n              <jats:styled-content style=\"fixed-case\">PVI<\/jats:styled-content>\n              in patients with\n              <jats:styled-content style=\"fixed-case\">ALI<\/jats:styled-content>\n              by comparing with patients treated for chronic critical limb ischemia using a regional quality improvement registry.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Of the 11\u00a0035 patients in the Vascular Study Group of New England\n              <jats:styled-content style=\"fixed-case\">PVI<\/jats:styled-content>\n              database (2010\u20132014), we identified 365 patients treated for lower extremity\n              <jats:styled-content style=\"fixed-case\">ALI<\/jats:styled-content>\n              who were 5:1 frequency matched (by procedure year and arterial segments treated) to 1808 patients treated for critical limb ischemia.\n              <jats:styled-content style=\"fixed-case\">ALI<\/jats:styled-content>\n              patients treated with\n              <jats:styled-content style=\"fixed-case\">PVI<\/jats:styled-content>\n              had high burden of atherosclerotic risk factors and were more likely to have had prior ipsilateral revascularizations.\n              <jats:styled-content style=\"fixed-case\">ALI<\/jats:styled-content>\n              patients were less likely to be treated with self\u2010expanding stents and more likely to undergo thrombolysis than patients with critical limb ischemia. In multivariable analysis,\n              <jats:styled-content style=\"fixed-case\">ALI<\/jats:styled-content>\n              was associated with higher technical failure (odds ratio 1.7, 95% confidence interval, 1.1%\u20132.5%), increased rate of distal embolization (odds ratio 2.7, 95% confidence interval, 1.5%\u20134.9%), longer length of stay (means ratio 1.6, 95% confidence interval, 1.4%\u20131.8%), and higher in\u2010hospital mortality (odds ratio 2.8, 95% confidence interval, 1.3%\u20135.9%).\n              <jats:styled-content style=\"fixed-case\">ALI<\/jats:styled-content>\n              was not associated with risk of major amputation or mortality at 1\u00a0year.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In a multicenter cohort of patients treated with\n              <jats:styled-content style=\"fixed-case\">PVI<\/jats:styled-content>\n              , we found that\n              <jats:styled-content style=\"fixed-case\">ALI<\/jats:styled-content>\n              patients selected for treatment with endovascular techniques experienced greater short\u2010term adverse events but similar long\u2010term outcomes as their critical limb ischemia counterparts. Further studies are needed to refine the selection of\n              <jats:styled-content style=\"fixed-case\">ALI<\/jats:styled-content>\n              patients who are best served by\n              <jats:styled-content style=\"fixed-case\">PVI<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.116.004782","type":"journal-article","created":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T09:55:13Z","timestamp":1523526913000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Outcomes of Peripheral Vascular Interventions in Select Patients With Lower Extremity Acute Limb Ischemia"],"prefix":"10.1161","volume":"7","author":[{"given":"Elica","family":"Inagaki","sequence":"first","affiliation":[{"name":"Department of Surgery, Boston Medical Center, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alik","family":"Farber","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery, Department of Surgery, Boston Medical Center, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Kalish","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery, Department of Surgery, Boston Medical Center, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad H.","family":"Eslami","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery, Department of Surgery, Boston Medical Center, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey J.","family":"Siracuse","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery, Department of Surgery, Boston Medical Center, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert T.","family":"Eberhardt","sequence":"additional","affiliation":[{"name":"Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis V.","family":"Rybin","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Boston University School of Public Health, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gheorghe","family":"Doros","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Boston University School of Public Health, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi M.","family":"Hamburg","sequence":"additional","affiliation":[{"name":"Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Vascular Study Group of New England","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.019355"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000086663.49670.d1"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.03.273"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.174526"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2013.04.036"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-821X(05)80239-7"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(94)70214-4"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199409000-00003"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(05)80036-9"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(96)70067-8"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199804163381603"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2015.09.055"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.003543"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.03.244"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2007.08.012"},{"key":"e_1_3_4_17_2","first-page":"45","article-title":"The Social Security Administration's Death Master File: the completeness of death reporting at older ages","volume":"64","author":"Hill ME","year":"2001","unstructured":"Hill ME, Rosenwaike I. 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