{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:40:31Z","timestamp":1790502031476,"version":"4.1.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Several different defibrillators are currently used for cardioversion and defibrillation of cardiac arrhythmias. The efficacy of a novel pulsed biphasic (\n              <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>\n              ) waveform has not been compared to other biphasic waveforms. Accordingly, this study aims to compare the efficacy and safety of\n              <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>\n              shocks with biphasic truncated exponential (\n              <jats:styled-content style=\"fixed-case\">BTE<\/jats:styled-content>\n              ) shocks in patients undergoing cardioversion of atrial fibrillation or \u2010flutter.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This prospective, randomized study included patients admitted for elective direct current cardioversion. Patients were randomized to receive cardioversion using either\n              <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>\n              or\n              <jats:styled-content style=\"fixed-case\">BTE<\/jats:styled-content>\n              shocks. We used escalating shocks until sinus rhythm was obtained or to a maximum of 4 shocks. Patients randomized to\n              <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>\n              shocks received 90, 120, 150, and 200\u00a0J and patients randomized to\n              <jats:styled-content style=\"fixed-case\">BTE<\/jats:styled-content>\n              shocks received 100, 150, 200, and 250\u00a0J, as recommended by the manufacturers. In total, 69 patients (51%) received\n              <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>\n              shocks and 65 patients (49%)\n              <jats:styled-content style=\"fixed-case\">BTE<\/jats:styled-content>\n              shocks. Successful cardioversion, defined as sinus rhythm 4\u00a0hours after cardioversion, was achieved in 43 patients (62%) using\n              <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>\n              shocks and in 56 patients (86%) using\n              <jats:styled-content style=\"fixed-case\">BTE<\/jats:styled-content>\n              shocks; ratio 1.4 (95% CI 1.1\u20131.7) (\n              <jats:italic>P<\/jats:italic>\n              =0.002). There was no difference in safety (ie, myocardial injury judged by changes in high\u2010sensitive troponin I levels; ratio 1.1) (95% CI 1.0\u20131.3),\n              <jats:italic>P<\/jats:italic>\n              =0.15. The study was terminated prematurely because of an adverse event.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Cardioversion using a\n              <jats:styled-content style=\"fixed-case\">BTE<\/jats:styled-content>\n              waveform was more effective when compared with a\n              <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>\n              waveform. There was no difference in safety between the 2 waveforms, as judged by changes in troponin I levels.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Clinical Trial Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">URL<\/jats:styled-content>\n              :\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier:\n              <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>\n              02317029.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.116.004853","type":"journal-article","created":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T01:45:44Z","timestamp":1489023944000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Cardioversion Efficacy Using Pulsed Biphasic or Biphasic Truncated Exponential Waveforms: A Randomized Clinical Trial"],"prefix":"10.1161","volume":"6","author":[{"given":"Anders S.","family":"Schmidt","sequence":"first","affiliation":[{"name":"Clinical Research Unit Regional Hospital of Randers Randers NE Denmark"},{"name":"Department of Internal Medicine Regional Hospital of Randers Randers NE Denmark"},{"name":"Research Center for Emergency Medicine Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper G.","family":"Lauridsen","sequence":"additional","affiliation":[{"name":"Clinical Research Unit Regional Hospital of Randers Randers NE Denmark"},{"name":"Department of Internal Medicine Regional Hospital of Randers Randers NE Denmark"},{"name":"Research Center for Emergency Medicine Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper","family":"Adelborg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Regional Hospital of Randers Randers NE Denmark"},{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Cardiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Torp","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Regional Hospital of Randers Randers NE Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif F.","family":"Bach","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Regional Hospital of Randers Randers NE Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon M.","family":"Jepsen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Regional Hospital of Randers Randers NE Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nete","family":"Hornung","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Regional Hospital of Randers Randers NE Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles D.","family":"Deakin","sequence":"additional","affiliation":[{"name":"NIHR Southampton Respiratory Biomedical Research Unit University Hospital Southampton NHS Foundation Trust Southampton United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Rickers","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Regional Hospital of Randers Randers NE Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"L\u00f8fgren","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Regional Hospital of Randers Randers NE Denmark"},{"name":"Research Center for Emergency Medicine Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005119"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.022"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2003.10.049"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.11.1282"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2006.03.017"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01898-3"},{"key":"e_1_3_2_8_2","unstructured":"Cansell A. Impulses or a series of impulses for defibrillation and device to generate them. US Patent. 2000; 6.493.580."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/03091900110038384"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/03091902.2010.514975"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/03091900110060776"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccx.0000125495.84614.b2"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000273"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq278"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11315-8"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2012.07.010"},{"key":"e_1_3_2_17_2","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2014","unstructured":"R Core Team . R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing; 2014. Available at: http:\/\/www.R-project.org\/. Accessed October 1, 2014."},{"key":"e_1_3_2_18_2","unstructured":"Schiller Medical Safety Notice Defigard 5000. Health Products Regulation Authority. 2014. Available at: http:\/\/www.hpra.ie\/docs\/default-source\/field-safety-notices\/October-2014\/v22248_fsn.pdf?sfvrsn=2. Accessed November 10 2016."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2007.08.010"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2009.05.013"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2007.01.014"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(03)00888-9"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.07.149"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2004.12.024"},{"key":"e_1_3_2_25_2","first-page":"664","article-title":"Cardiac troponin I after external electrical cardioversion for atrial fibrillation as a marker of myocardial injury\u2014a preliminary report","volume":"65","author":"Piechota W","year":"2007","unstructured":"Piechota W, Gielerak G, Ryczek R, Kazmierczak A, Bejm J, Piechota W. Cardiac troponin I after external electrical cardioversion for atrial fibrillation as a marker of myocardial injury\u2014a preliminary report. Kardiol Pol. 2007;65:664\u2013669; discussion 670\u20101.","journal-title":"Kardiol Pol"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00260-X"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1999.1745"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.111.1.15"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2000.109646"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2006.12.014"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.5.2308"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2007.120782"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.116.004853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:26:53Z","timestamp":1715596013000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.116.004853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1161\/JAHA.116.004853"],"URL":"https:\/\/doi.org\/10.1161\/jaha.116.004853","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"2016-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e004853"}}