{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T01:53:40Z","timestamp":1788054820365,"version":"build-2784847793"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We aimed to investigate the regulatory effects of hydrogen sulfide (H\n                      <jats:sub>2<\/jats:sub>\n                      S) on carotid sinus baroreceptor sensitivity and its mechanisms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Male Wistar\u2010Kyoto rats and spontaneously hypertensive rats (SHRs) were used in the experiment and were given an H\n                      <jats:sub>2<\/jats:sub>\n                      S donor or a cystathionine\u2010\u03b2\u2010synthase inhibitor, hydroxylamine, for 8\u00a0weeks. Systolic blood pressure and the cystathionine\u2010\u03b2\u2010synthase\/H\n                      <jats:sub>2<\/jats:sub>\n                      S pathway in carotid sinus were detected. Carotid sinus baroreceptor sensitivity and the functional curve of the carotid baroreceptor were analyzed using the isolated carotid sinus perfusion technique. Effects of H\n                      <jats:sub>2<\/jats:sub>\n                      S on transient receptor potential cation channel subfamily V member 1 (TRPV1) expression and S\u2010sulfhydration were detected. In SHRs, systolic blood pressure was markedly increased, but the cystathionine\u2010\u03b2\u2010synthase\/H\n                      <jats:sub>2<\/jats:sub>\n                      S pathway in the carotid sinus was downregulated in comparison to that of Wistar\u2010Kyoto rats. Carotid sinus baroreceptor sensitivity in SHRs was reduced, demonstrated by the right and upward shift of the functional curve of the carotid baroreceptor. Meanwhile, the downregulation of TRPV1 protein was demonstrated in the carotid sinus; however, H\n                      <jats:sub>2<\/jats:sub>\n                      S reduced systolic blood pressure but enhanced carotid sinus baroreceptor sensitivity in SHRs, along with TRPV1 upregulation in the carotid sinus. In contrast, hydroxylamine significantly increased the systolic blood pressure of Wistar\u2010Kyoto rats, along with decreased carotid sinus baroreceptor sensitivity and reduced TRPV1 protein expression in the carotid sinus. Furthermore, H\n                      <jats:sub>2<\/jats:sub>\n                      S\u2010induced enhancement of carotid sinus baroreceptor sensitivity of SHRs could be amplified by capsaicin but reduced by capsazepine. Moreover, H\n                      <jats:sub>2<\/jats:sub>\n                      S facilitated S\u2010sulfhydration of TRPV1 protein in the carotid sinus of SHRs and Wistar\u2010Kyoto rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      H\n                      <jats:sub>2<\/jats:sub>\n                      S regulated blood pressure via an increase in\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">TRPV<\/jats:styled-content>\n                      1 protein expression and its activity to enhance carotid sinus baroreceptor sensitivity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.116.004971","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T20:20:21Z","timestamp":1494966021000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":30,"title":["Endogenous Hydrogen Sulfide Enhances Carotid Sinus Baroreceptor Sensitivity by Activating the Transient Receptor Potential Cation Channel Subfamily V Member 1 (TRPV1) Channel"],"prefix":"10.1161","volume":"6","author":[{"given":"Wen","family":"Yu","sequence":"first","affiliation":[{"name":"Peking University First Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liao","sequence":"additional","affiliation":[{"name":"Peking University First Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqian","family":"Huang","sequence":"additional","affiliation":[{"name":"Peking University First Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selena Y.","family":"Chen","sequence":"additional","affiliation":[{"name":"University of California, San Diego","place":["La Jolla"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[{"name":"Peking University First Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chufan","family":"Sun","sequence":"additional","affiliation":[{"name":"Peking University First Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Wu","sequence":"additional","affiliation":[{"name":"Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoshu","family":"Tang","sequence":"additional","affiliation":[{"name":"Peking University Health Science Centre","place":["Beijing, China"]},{"name":"Ministry of Education","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbao","family":"Du","sequence":"additional","affiliation":[{"name":"Peking University First Hospital","place":["Beijing, China"]},{"name":"Ministry of Education","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfang","family":"Jin","sequence":"additional","affiliation":[{"name":"Peking University First Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"593","DOI":"10.33549\/physiolres.930768","article-title":"Age\u2010dependent relationship between the carotid intima\u2010media thickness, baroreflex sensitivity, and the inter\u2010beat interval in normotensive and hypertensive subjects","volume":"54","author":"L\u00e1brov\u00e1 R","year":"2005","unstructured":"L\u00e1brov\u00e1 R, Honz\u00edkov\u00e1 N, Maderov\u00e1 E, Vysocanov\u00e1 P, Nov\u00e1kov\u00e1 Z, Z\u00e1vodn\u00e1 E, Fiser B, Semr\u00e1d B. 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