{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:25:47Z","timestamp":1790630747455,"version":"4.1.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec xml:lang=\"en\"><jats:title>Background<\/jats:title><jats:p xml:lang=\"en\">Adipokines are implicated in the development of obesity\u2010related traits. We hypothesized that nonobese participants without diabetes mellitus (DM) whose parents were obese or had<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>would have altered circulating adipokines compared with those without parental history of these conditions.<\/jats:p><\/jats:sec><jats:sec xml:lang=\"en\"><jats:title>Methods and Results<\/jats:title><jats:p xml:lang=\"en\">Participants in the community\u2010based Framingham Third Generation cohort who were not obese (body mass index &lt;30) and not diabetic with both parents in the Framingham Offspring cohort were included in this analysis (n=2034, mean age 40 years, 54% women). Circulating concentrations of fetuin A, RBP4 (retinol binding protein 4), FABP4 (fatty acid binding protein 4), leptin, LEP\u2010R (leptin receptor), and adiponectin were assayed. Parental<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>was defined as occurring before age 60\u00a0years, and obesity was defined as body mass index \u226530 before age 60\u00a0years. General estimating equations were used to compare concentrations of adipokines among participants with 0, 1, or 2 parents affected by obesity or<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>(separate analyses for each), adjusting for known correlates of adipokines. Overall, 44% had at least 1 parent who was obese and 15% had parents with<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>. Parental obesity was associated with higher serum levels of<jats:styled-content style=\"fixed-case\">FABP<\/jats:styled-content>4 and<jats:styled-content style=\"fixed-case\">LEP<\/jats:styled-content>\u2010R in their offspring (<jats:italic>P<\/jats:italic>=0.02 for both). Parental<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>was associated with lower adiponectin but higher<jats:styled-content style=\"fixed-case\">RBP<\/jats:styled-content>4 concentrations in offspring (<jats:italic>P<\/jats:italic>\u22640.02 for both).<\/jats:p><\/jats:sec><jats:sec xml:lang=\"en\"><jats:title>Conclusions<\/jats:title><jats:p xml:lang=\"en\">In our community\u2010based sample, a parental history of<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>or obesity was associated with an altered adipokine profile in nonobese nondiabetic offspring. Additional studies are warranted to evaluate whether such preclinical biomarker alterations presage future risk of disease.<\/jats:p><\/jats:sec>","DOI":"10.1161\/jaha.116.004973","type":"journal-article","created":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T00:10:09Z","timestamp":1500250209000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Association of Parental Obesity and Diabetes Mellitus With Circulating Adipokines in Nonobese Nondiabetic Offspring"],"prefix":"10.1161","volume":"6","author":[{"given":"Justin P.","family":"Zachariah","sequence":"first","affiliation":[{"name":"Section of Pediatric Cardiology, Department of Pediatrics, Texas Children's Hospital Baylor College of Medicine, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"Quiroz","sequence":"additional","affiliation":[{"name":"Cardiology Section, Boston University, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Enserro","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Boston University School of Public Health, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Gentofte Hospital, Hellerup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"John F.","family":"Keaney","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramachandran S.","family":"Vasan","sequence":"additional","affiliation":[{"name":"Cardiology Section, Boston University, Boston, MA"},{"name":"Preventive Medicine Section, Boston University, Boston, MA"},{"name":"Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA"},{"name":"Boston University's and the National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.14.1472"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.2.187"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.732"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.03.023"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/50.6.1308"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199709253371301"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2921"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.12.023"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2012.03.004"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1458"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm021"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-7-200510040-00005"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00448a003"},{"key":"e_1_3_3_15_2","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S0026-895X(25)08970-9","article-title":"Adipocyte fatty acid\u2010binding protein: regulation of gene expression in\u00a0vivo and in\u00a0vitro by an insulin\u2010sensitizing agent","volume":"42","author":"Kletzien RF","year":"1992","unstructured":"Kletzien RF, Foellmi LA, Harris PK, Wyse BM, Clarke SD. 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