{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T09:12:39Z","timestamp":1764493959884,"version":"3.41.2"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Adipokines are elaborated by adipose tissue and are associated with glycemic, lipid, and vascular traits. We hypothesized that in a cross\u2010sectional analysis circulating adipokines are altered among subsets of obesity stratified by presence versus absence of metabolic syndrome (MetS) and prospectively predict the incidence of MetS.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Participants in the community\u2010based Framingham Third Generation Cohort who attended examination cycle 1 were included in the study (2002\u20132005; N=3777, mean age, 40\u00a0years; 59% women). Circulating adiponectin, leptin, leptin receptor, fetuin\u2010A, fatty acid\u2013binding protein 4, and retinol binding protein 4 were assayed and related to incident MetS in follow\u2010up (mean 6\u00a0years). The adipokines were compared among individuals with excess body weight (body mass index \u226525\u00a0kg\/m\n              <jats:sup>2<\/jats:sup>\n              ) and prevalent MetS, excess body weight without MetS (metabolically healthy obese), and normal\u2010weight with MetS (metabolically obese, normal\u2010weight) with normal\u2010weight participants without MetS as a referent. Metabolically healthy obese individuals (n=1467) had higher circulating levels of fetuin\u2010A and fatty acid\u2013binding protein 4 but lower levels of leptin, leptin receptor, and adiponectin (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001 for all). The adipokine panel was associated with incident MetS (263 new\u2010onset cases;\n              <jats:italic>P<\/jats:italic>\n              =0.002). Higher circulating concentrations of retinol\u2010binding protein 4 and fetuin\u2010A were associated with incidence of MetS (odds ratio per 1\u2010\n              <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n              increment log marker, 1.21; 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 1.03\u20131.41 [\n              <jats:italic>P<\/jats:italic>\n              =0.02] and 1.17; 95% CI, 1.01\u20131.34 [\n              <jats:italic>P<\/jats:italic>\n              =0.03], respectively).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In our community\u2010based sample of young to middle\u2010aged adults, metabolically healthy obese individuals demonstrated an adverse adipokine profile. Higher circulating levels of retinol\u2010binding protein 4 and fetuin\u2010A marked future cardiometabolic risk.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.116.004974","type":"journal-article","created":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T00:10:09Z","timestamp":1500250209000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["Prospective Relation of Circulating Adipokines to Incident Metabolic Syndrome: The Framingham Heart Study"],"prefix":"10.1161","volume":"6","author":[{"given":"Justin P.","family":"Zachariah","sequence":"first","affiliation":[{"name":"Section of Pediatric Cardiology, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rene","family":"Quiroz","sequence":"additional","affiliation":[{"name":"Cardiology Section, Boston University, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerrie P.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Boston University School of Public Health, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoyang","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Boston University School of Public Health, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"John F.","family":"Keaney","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Boston University School of Public Health, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramachandran S.","family":"Vasan","sequence":"additional","affiliation":[{"name":"Cardiology Section, Boston University, Boston, MA"},{"name":"Preventive Medicine Section, Boston University, Boston, MA"},{"name":"Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA"},{"name":"Boston University's and the National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192644"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.169404"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.15.1617"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e318233bc6a"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90445-X"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2921"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm021"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2165"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.588723"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03711"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.887521"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0594"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12157"},{"key":"e_1_3_3_16_2","first-page":"581","article-title":"Association of weight status with mortality in adults with incident diabetes","volume":"308","author":"Carnethon MR","year":"2012","unstructured":"Carnethon MR, De Chavez PJ, Biggs ML, Lewis CE, Pankow JS, Bertoni AG, Golden SH, Liu K, Mukamal KJ, Campbell\u2010Jenkins B, Dyer AR. 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