{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:26:15Z","timestamp":1789820775773,"version":"4.0.1"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,2,2]]},"abstract":"\n Background<\/jats:title>\n \n Although aortic stiffness assessed by pulse wave velocity (\n PWV<\/jats:styled-content>\n ) is a strong predictor of coronary artery disease, the significance of local coronary stiffness has never been tackled. The first objective of this study was to describe a method of measuring coronary\n PWV<\/jats:styled-content>\n (Co\n PWV<\/jats:styled-content>\n ) invasively and to describe its determinants. The second objective was to assess both Co\n PWV<\/jats:styled-content>\n and aortic\n PWV<\/jats:styled-content>\n in patients presenting with acute coronary syndromes or stable coronary artery disease.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n In 53 patients, Co\n PWV<\/jats:styled-content>\n was measured from the delay in pressure wave and distance traveled as a pressure wire was withdrawn from the distal to the proximal coronary segment. Similarly, aortic\n PWV<\/jats:styled-content>\n was measured invasively when the wire was pulled across the ascending aorta; carotid\u2013femoral\n PWV<\/jats:styled-content>\n was also measured noninvasively using the SphygmoCor system (AtCor Medical). Mean Co\n PWV<\/jats:styled-content>\n was 10.3\u00b16.1\u00a0m\/s. Determinants of increased Co\n PWV<\/jats:styled-content>\n were fractional flow reserve, diastolic blood pressure, and previous stent implantation in the recorded artery. Co\n PWV<\/jats:styled-content>\n was lower in patients with acute coronary syndromes versus stable coronary artery disease (7.6\u00b13\u00a0versus 11.5\u00b16.4\u00a0m\/s;\n P<\/jats:italic>\n =0.02), and this persisted after adjustment for confounders. In contrast, aortic stiffness, assessed by aortic and carotid\u2013femoral\n PWV<\/jats:styled-content>\n , did not differ significantly.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Co\n PWV<\/jats:styled-content>\n seems associated with acute coronary events more closely than aortic\n PWV<\/jats:styled-content>\n . High coronary compliance, whether per se or because it leads to a distal shift in compliance mismatch, may expose vulnerable plaques to high cyclic stretch. Co\n PWV<\/jats:styled-content>\n is a new tool to assess local compliance at the coronary level; it paves the way for a new field of research.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.116.004981","type":"journal-article","created":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T01:57:08Z","timestamp":1486087028000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Development of Coronary Pulse Wave Velocity: New Pathophysiological Insight Into Coronary Artery Disease"],"prefix":"10.1161","volume":"6","author":[{"given":"Brahim","family":"Harbaoui","sequence":"first","affiliation":[{"name":"Cardiology Department, European Society of Hypertension Excellence Center H\u00f4pital de la Croix\u2010Rousse Hospices Civils de Lyon, Lyon, France"},{"name":"CREATIS, CNRS UMR5220, INSERM U1044, INSA\u2010Lyon, Universit\u00e9 Claude Bernard Lyon 1 Hospices Civils de Lyon Universit\u00e9 de Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Yves","family":"Courand","sequence":"additional","affiliation":[{"name":"Cardiology Department, European Society of Hypertension Excellence Center H\u00f4pital de la Croix\u2010Rousse Hospices Civils de Lyon, Lyon, France"},{"name":"CREATIS, CNRS UMR5220, INSERM U1044, INSA\u2010Lyon, Universit\u00e9 Claude Bernard Lyon 1 Hospices Civils de Lyon Universit\u00e9 de Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Cividjian","sequence":"additional","affiliation":[{"name":"Cardiology Department, European Society of Hypertension Excellence Center H\u00f4pital de la Croix\u2010Rousse Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Lantelme","sequence":"additional","affiliation":[{"name":"Cardiology Department, European Society of Hypertension Excellence Center H\u00f4pital de la Croix\u2010Rousse Hospices Civils de Lyon, Lyon, France"},{"name":"CREATIS, CNRS UMR5220, INSERM U1044, INSA\u2010Lyon, Universit\u00e9 Claude Bernard Lyon 1 Hospices Civils de Lyon Universit\u00e9 de Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.09.011"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.5.1236"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.09.063"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.133116"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.04.039"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2006.11.053"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.84.3.314"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.05.007"},{"key":"e_1_3_3_10_2","first-page":"H469","article-title":"Propagation velocity and reflection of pressure waves in the canine coronary artery","volume":"237","author":"Arts T","year":"1979","unstructured":"Arts T, Kruger RT, van Gerven W, Lambregts JA, Reneman RS. 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