{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T18:46:51Z","timestamp":1772131611428,"version":"3.50.1"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,11,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Enlargement of the proximal aorta is associated with aortic wall tissue remodeling, including fragmentation of the elastin fibers, increased synthesis of collagen, and calcification, all of which are associated with aortic wall stiffening. We hypothesized that the proximal aortic diameter (AoD) is associated with cardiovascular events in a community\u2010based cohort of blacks.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We investigated the associations between AoD and cardiovascular events among 3018 black participants (mean age, 55.9\u00a0years; 69% women) without past history of cardiovascular disease in the Jackson Heart Study. AoD was measured using echocardiography at the level of the sinuses of Valsalva at end diastole. Cardiovascular event was defined as incident myocardial infarction, fatal coronary artery disease, stroke, or heart failure hospitalization. Cox proportional hazards regression models were used to evaluate the association between baseline AoD and cardiovascular events. Over a median follow\u2010up of 8.3\u00a0years, there were 258 cardiovascular events (incident rate, 10.5 per 1000\u00a0person\u2010years). After adjustment for traditional risk factors, increased AoD was significantly associated with cardiovascular events (hazard ratio per 1\u2010cm increase, 1.72; 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 1.10\u20132.69;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05). Participants in the top AoD quintile had a higher incidence of cardiovascular events compared to those not in the top quintile (hazard ratio, 1.47; 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 1.11\u20131.94;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.005) after adjustment for risk factors.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Greater AoD was associated with an increased risk of cardiovascular events in a community\u2010based cohort of blacks. AoD may be useful as a predictor of incident cardiovascular events and further investigation is warranted.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.116.005005","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T00:20:26Z","timestamp":1498090826000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Increased Proximal Aortic Diameter is Associated With Risk of Cardiovascular Events and All\u2010Cause Mortality in Blacks The Jackson Heart Study"],"prefix":"10.1161","volume":"6","author":[{"given":"Daisuke","family":"Kamimura","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Mississippi Medical Center, Jackson, MS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeki","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Mississippi Medical Center, Jackson, MS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solomon K.","family":"Musani","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Mississippi Medical Center, Jackson, MS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Mississippi Medical Center, Jackson, MS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tandaw E.","family":"Samdarshi","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Mississippi Medical Center, Jackson, MS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adolfo","family":"Correa","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Mississippi Medical Center, Jackson, MS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ervin R.","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Mississippi Medical Center, Jackson, MS"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.3.734"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000153793.84859.b8"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000093435.04334.1F"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.101196"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01447-4"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.099515"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.12.050"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2012.10.003"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.08.039"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2013.111"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000264"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-996-0025-8"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000350"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-012-9362-y"},{"key":"e_1_3_5_16_2","first-page":"S6\u20101\u20103","article-title":"The Jackson Heart Study: an overview","volume":"15","author":"Taylor HA","year":"2005","unstructured":"Taylor HA Jr. The Jackson Heart Study: an overview. 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