{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:18:41Z","timestamp":1762507121436,"version":"3.41.2"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,11,6]]},"abstract":"\n Background<\/jats:title>\n \n Brugada syndrome (BrS) is an inherited primary arrhythmia disorder leading to sudden cardiac arrest.\n \n SCN<\/jats:styled-content>\n 5A\n <\/jats:italic>\n , encoding the \u03b1\u2010subunit of the cardiac sodium channel (Nav1.5), is the most common pathogenic gene of BrS. An implantable cardioverter defibrillator (\n ICD<\/jats:styled-content>\n ) is the standard treatment for secondary prevention. This study aimed to evaluate association of the\n \n SCN<\/jats:styled-content>\n 5A\n <\/jats:italic>\n variant with this cardiac conduction disturbance and appropriate\n ICD<\/jats:styled-content>\n shock therapy in Thai symptomatic BrS patients with\n ICD<\/jats:styled-content>\n implants.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Symptomatic BrS patients diagnosed at university hospital were enrolled from 2008 to 2011. The primary outcome of the study was an appropriate\n ICD<\/jats:styled-content>\n shock defined as having non\u2010pacing\u2010associated\n ICD<\/jats:styled-content>\n shock after the occurrence of ventricular tachycardia or ventricular fibrillation. Associations between\n \n SCN<\/jats:styled-content>\n 5A\n <\/jats:italic>\n polymorphisms, cardiac conduction disturbance, and potential confounding factors associated with appropriate\n ICD<\/jats:styled-content>\n shock therapy were analyzed. All 40 symptomatic BrS patients (median age, 43\u00a0years) with\n ICD<\/jats:styled-content>\n implantations were followed for 24\u00a0months. There were 16 patients (40%) who had the appropriate\n ICD<\/jats:styled-content>\n shock therapy after\n ICD<\/jats:styled-content>\n treatment. An independent factor associated with appropriate\n ICD<\/jats:styled-content>\n shock therapy was\n \n SCN<\/jats:styled-content>\n 5A\u2010\n <\/jats:italic>\n R1193Q with an adjusted hazard ratio of 10.550 (95%\n CI<\/jats:styled-content>\n , 1.631\u201368.232).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n \n SCN<\/jats:styled-content>\n 5A\u2010\n <\/jats:italic>\n R1193Q is associated with cardiac conduction disturbances. It may be a genetic marker associated with ventricular arrhythmia leading to appropriate\n ICD<\/jats:styled-content>\n shock therapy in symptomatic BrS patients with\n ICD<\/jats:styled-content>\n treatment. Because of the small sample size of study population and the appropriate\n ICD<\/jats:styled-content>\n shock outcome, further large studies are needed to confirm the results of this study.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.116.005009","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T00:20:21Z","timestamp":1496708421000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["SCN5A<\/i>\n Genetic Polymorphisms Associated With Increased Defibrillator Shocks in Brugada Syndrome"],"prefix":"10.1161","volume":"6","author":[{"given":"Pattarapong","family":"Makarawate","sequence":"first","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narumol","family":"Chaosuwannakit","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suda","family":"Vannaprasaht","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dujdao","family":"Sahasthas","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok Hwee","family":"Koo","sequence":"additional","affiliation":[{"name":"NUS Pharmacogenetics Laboratory, Department of Pharmacology, National University of Singapore, Singapore"},{"name":"Clinical Trials & Research Unit, Changi General Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund Jon Deoon","family":"Lee","sequence":"additional","affiliation":[{"name":"NUS Pharmacogenetics Laboratory, Department of Pharmacology, National University of Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wichittra","family":"Tassaneeyakul","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector","family":"Barajas\u2010Martinez","sequence":"additional","affiliation":[{"name":"Molecular Genetic Department, Masonic Medical Research Laboratory, Utica, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Hu","sequence":"additional","affiliation":[{"name":"Molecular Genetic Department, Masonic Medical Research Laboratory, Utica, NY"},{"name":"Department of Cardiology & Cardiovascular Research Institute, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kittisak","family":"Sawanyawisuth","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand"},{"name":"Research Center in Back, Neck Other Joint Pain and Human Performance (BNOJPH), and Sleep Apnea Research Group, Khon Kaen University, Khon Kaen, 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