{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:38:01Z","timestamp":1790699881943,"version":"4.1.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Several studies have suggested that cytomegalovirus infection is likely associated with an increased relative risk of cardiovascular disease (\n                      <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                      ); however, the results are inconsistent. We aimed to provide a systematic review and meta\u2010analysis of community\u2010based prospective studies assessing the association between cytomegalovirus infection and relative risk of\n                      <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We searched Medline and\n                      <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>\n                      to retrieve prospective studies that reported risk estimates of the association between cytomegalovirus infection and relative risk of\n                      <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                      . The search yielded 10 articles including a total of 34\u00a0564 participants and 4789\n                      <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                      patients. Overall, exposure to cytomegalovirus infection was associated with a 22% (relative risk: 1.22, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 1.07\u20131.38,\n                      <jats:italic>P<\/jats:italic>\n                      =0.002) increased relative risk of future\n                      <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                      . We estimated that 13.4% of\n                      <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                      incidence could be attributable to cytomegalovirus infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      In conclusion, cytomegalovirus infection is associated with a significantly increased relative risk of\n                      <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.116.005025","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T20:10:51Z","timestamp":1499371851000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":177,"title":["Cytomegalovirus Infection and Relative Risk of Cardiovascular Disease (Ischemic Heart Disease, Stroke, and Cardiovascular Death): A Meta\u2010Analysis of Prospective Studies Up to 2016"],"prefix":"10.1161","volume":"6","author":[{"given":"Haoran","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology Ward 2, Luohe Central Hospital, The First Affiliated Hospital of Luohe Medical College, Luohe, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geng","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ward 2, Luohe Central Hospital, The First Affiliated Hospital of Luohe Medical College, Luohe, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes, Luohe Central Hospital, The First Affiliated Hospital of Luohe Medical College, Luohe, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"He","sequence":"additional","affiliation":[{"name":"Department of Joint Surgery, Luohe Central Hospital, The First Affiliated Hospital of Luohe Medical College, Luohe, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kecheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinrong","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ward 2, Luohe Central Hospital, The First Affiliated Hospital of Luohe Medical College, Luohe, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongliang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ward 2, Luohe Central Hospital, The First Affiliated Hospital of Luohe Medical College, Luohe, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","first-page":"417","article-title":"Manifestations of human cytomegalovirus infection: proposed mechanisms of acute and chronic disease","volume":"325","author":"Britt W","year":"2008","unstructured":"Britt W. 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