{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:15:33Z","timestamp":1792505733337,"version":"4.5.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Ischemic and hemorrhagic stroke are increasingly recognized as heterogeneous diseases with distinct subtypes and etiologies. Information on variation in distribution of vascular risk factors according to age in stroke subtypes is limited. We investigated the prevalence of vascular risk factors in stroke subtypes in relation to age.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We studied a prospective multicenter university hospital\u2013based cohort of 4033 patients. For patients with ischemic stroke caused by large artery atherosclerosis, small vessel disease, or cardioembolism and for patients with spontaneous intracerebral hemorrhage or aneurysmal subarachnoid hemorrhage, we calculated prevalences of vascular risk factors in 4 age groups: &lt;55, 55 to 65, 65 to 75, and \u226575\u00a0years, and mean differences with 95% CIs in relation to the reference age group. Patients aged &lt;55\u00a0years were significantly more often of non\u2010white origin (in particular in spontaneous intracerebral hemorrhage and aneurysmal subarachnoid hemorrhage patients) and most often smoked (most prominent for aneurysmal subarachnoid hemorrhage patients). Patients aged &lt;55\u00a0years with ischemic stroke caused by large artery atherosclerosis or small vessel disease more often had hypertension, hyperlipidemia, and diabetes mellitus than patients with ischemic stroke of cardiac origin. Overall, the frequency of hypertension, hyperlipidemia, and diabetes mellitus increased with age among all stroke subtypes, whereas smoking decreased with age. Regardless of age, accumulation of potentially modifiable risk factors was most pronounced in patients with ischemic stroke caused by large artery atherosclerosis or small vessel disease.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The prevalence of common cardiovascular risk factors shows different age\u2010specific patterns among various stroke subtypes. Recognition of these patterns may guide tailored stroke prevention efforts aimed at specific risk groups.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.116.005090","type":"journal-article","created":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T20:40:22Z","timestamp":1494276022000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":57,"title":["Age\u2010Specific Vascular Risk Factor Profiles According to Stroke Subtype"],"prefix":"10.1161","volume":"6","author":[{"given":"Allard J.","family":"Hauer","sequence":"first","affiliation":[{"name":"University Medical Center Utrecht","place":["Utrecht, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ynte M.","family":"Ruigrok","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht","place":["Utrecht, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ale","family":"Algra","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht","place":["Utrecht, The Netherlands"]},{"name":"University Medical Center Utrecht","place":["Utrecht, The Netherlands"]},{"name":"Leiden University Medical Center","place":["Leiden, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewoud J.","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center","place":["Nijmegen, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Koudstaal","sequence":"additional","affiliation":[{"name":"Erasmus Medical Center","place":["Rotterdam, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert\u2010Jan","family":"Luijckx","sequence":"additional","affiliation":[{"name":"University Medical Center Groningen","place":["Groningen, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Nederkoorn","sequence":"additional","affiliation":[{"name":"Academic Medical Center","place":["Amsterdam, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"van Oostenbrugge","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Center","place":["Maastricht, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke C.","family":"Visser","sequence":"additional","affiliation":[{"name":"VU Medical Center","place":["Amsterdam, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke J.","family":"Wermer","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center","place":["Leiden, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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