{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:16:38Z","timestamp":1787508998654,"version":"build-2736575974"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The immune system plays a pivotal role in myocardial homeostasis and response to injury. Interleukins\u20104 and \u201013 are anti\u2010inflammatory type\u20102 cytokines, signaling via the common interleukin\u201013 receptor \u03b11 chain and the type\u20102 interleukin\u20104 receptor. The role of interleukin\u201013 receptor \u03b11 in the heart is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We analyzed myocardial samples from human donors (n=136) and patients with end\u2010stage heart failure (n=177). We found that the interleukin\u201013 receptor \u03b11 is present in the myocardium and, together with the complementary type\u20102 interleukin\u20104 receptor chain\n                      <jats:italic toggle=\"yes\">Il4ra<\/jats:italic>\n                      , is significantly downregulated in the hearts of patients with heart failure. Next, we showed that\n                      <jats:italic toggle=\"yes\">Il13ra1<\/jats:italic>\n                      \u2010deficient mice develop severe myocardial dysfunction and dyssynchrony compared to wild\u2010type mice (left ventricular ejection fraction 29.7\u00b19.9 versus 45.0\u00b18.0;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.004, left ventricular end\u2010diastolic diameter 4.2\u00b10.2 versus 3.92\u00b10.3;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.03). A bioinformatic analysis of mouse hearts indicated that interleukin\u201013 receptor \u03b11 regulates critical pathways in the heart other than the immune system, such as extracellular matrix (normalized enrichment score=1.90; false discovery rate q=0.005) and glucose metabolism (normalized enrichment score=\u22122.36; false discovery rate q=0). Deficiency of\n                      <jats:italic toggle=\"yes\">Il13ra1<\/jats:italic>\n                      was associated with reduced collagen deposition under normal and pressure\u2010overload conditions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">The results of our studies in humans and mice indicate, for the first time, a role of interleukin\u201013 receptor \u03b11 in myocardial homeostasis and heart failure and suggests a new therapeutic target to treat heart disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.116.005108","type":"journal-article","created":{"date-parts":[[2017,5,20]],"date-time":"2017-05-20T20:10:15Z","timestamp":1495311015000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":41,"title":["New Role for Interleukin\u201013 Receptor \u03b11 in Myocardial Homeostasis and Heart Failure"],"prefix":"10.1161","volume":"6","author":[{"given":"Uri","family":"Amit","sequence":"first","affiliation":[{"name":"Tel Aviv University","place":["Tel\u2010Hashomer, Israel"]},{"name":"Sheba Medical Center","place":["Tel\u2010Hashomer, Israel"]},{"name":"Sheba Medical Center","place":["Tel\u2010Hashomer, Israel"]},{"name":"Sheba Medical Center","place":["Tel\u2010Hashomer, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kain","sequence":"additional","affiliation":[{"name":"Tel Aviv University","place":["Tel\u2010Hashomer, Israel"]},{"name":"Sheba Medical Center","place":["Tel\u2010Hashomer, Israel"]},{"name":"Sheba Medical Center","place":["Tel\u2010Hashomer, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allon","family":"Wagner","sequence":"additional","affiliation":[{"name":"Tel Aviv University","place":["Tel Aviv, Israel"]},{"name":"University of California","place":["Berkeley"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avinash","family":"Sahu","sequence":"additional","affiliation":[{"name":"University of Maryland","place":["College Park"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Nevo\u2010Caspi","sequence":"additional","affiliation":[{"name":"Safra Children's Hospital","place":["Tel\u2010Hashomer, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Gonen","sequence":"additional","affiliation":[{"name":"Tel Aviv University","place":["Tel Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natali","family":"Molotski","sequence":"additional","affiliation":[{"name":"Tel Aviv University","place":["Tel\u2010Hashomer, Israel"]},{"name":"Sheba Medical Center","place":["Tel\u2010Hashomer, Israel"]},{"name":"Sheba Medical Center","place":["Tel\u2010Hashomer, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Konfino","sequence":"additional","affiliation":[{"name":"Tel Aviv University","place":["Tel\u2010Hashomer, Israel"]},{"name":"Sheba Medical Center","place":["Tel\u2010Hashomer, Israel"]},{"name":"Sheba Medical Center","place":["Tel\u2010Hashomer, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Landa","sequence":"additional","affiliation":[{"name":"Tel Aviv University","place":["Tel\u2010Hashomer, Israel"]},{"name":"Sheba Medical Center","place":["Tel\u2010Hashomer, Israel"]},{"name":"Sheba Medical Center","place":["Tel\u2010Hashomer, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nili","family":"Naftali\u2010Shani","sequence":"additional","affiliation":[{"name":"Tel Aviv University","place":["Tel\u2010Hashomer, Israel"]},{"name":"Sheba Medical Center","place":["Tel\u2010Hashomer, Israel"]},{"name":"Sheba Medical 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