{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T21:44:05Z","timestamp":1780609445967,"version":"3.54.1"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,11,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Disopyramide is effective in ameliorating symptoms in patients with hypertrophic cardiomyopathy; however, its potential for proarrhythmic effect has raised concerns about its use in the ambulatory setting. The risk of initiating disopyramide in this manner has never been evaluated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              All charts of patients seen in the outpatient hypertrophic cardiomyopathy clinic between 2010 and 2014 were screened for initiation of disopyramide and data were extracted. Disopyramide in our clinic is usually initiated at a dose of 300\u00a0mg daily and titrated during follow\u2010up. A total of 2015 patients were seen in the clinic, including 168 who were started on disopyramide. There were no cardiac events within 3\u00a0months of disopyramide initiation. During long\u2010term follow\u2010up (255\u00a0patient\u2010years; mean, 447\u00a0days; interquartile range, 201\u2013779), only 2 patients developed cardiac events (syncope of unknown cause in both). Thirty\u2010eight patients (23%) developed side effects of disopyramide and 18 (11%) stopped the drug because of these side effects. Of the patients continuing disopyramide long term, 63% remained free of septal reduction interventions at end of follow\u2010up. Disopyramide at a dose of 300\u00a0mg prolonged the mean\n              <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>\n              c interval by 19\u00b123\u00a0ms; however, increasing the dose to 600\u00a0mg had no further significant effect.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Initiation of disopyramide in the outpatient setting is safe and the risk of subsequent sudden cardiac death is low. Because of its\n              <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>\n              \u2010prolonging effect, precautions may be necessary in patients at higher risk of torsades de pointes.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.116.005152","type":"journal-article","created":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T00:35:22Z","timestamp":1495845322000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":74,"title":["Safety of Outpatient Initiation of Disopyramide for Obstructive Hypertrophic Cardiomyopathy Patients"],"prefix":"10.1161","volume":"6","author":[{"given":"Arnon","family":"Adler","sequence":"first","affiliation":[{"name":"Division of Cardiology, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Fourey","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adaya","family":"Weissler\u2010Snir","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waseem","family":"Hindieh","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond H.","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Gollob","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Rakowski","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.4.785"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2007.126003"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60397-3"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.112.000122"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu284"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.06.011"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198210143071607"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(88)90269-X"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.01.012"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1981.00340070126029"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100010"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1L698"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199302000-00019"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2012.04.003"},{"key":"e_1_3_3_16_2","first-page":"II7","article-title":"Inpatient versus outpatient initiation of antiarrhythmic drug therapy for patients with supraventricular tachycardia","volume":"17","author":"Prystowsky EN","year":"1994","unstructured":"Prystowsky EN. 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Clin Cardiol. 1994;17:II7\u2013II10.","journal-title":"Clin Cardiol"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00189-2"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000085057.63483.9b"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.116.005152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:31:24Z","timestamp":1715596284000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.116.005152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,6]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,11,6]]}},"alternative-id":["10.1161\/JAHA.116.005152"],"URL":"https:\/\/doi.org\/10.1161\/jaha.116.005152","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,6]]},"assertion":[{"value":"2016-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e005152"}}