{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:29:41Z","timestamp":1792679381690,"version":"4.5.0"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,11,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Reliable measurement of blood pressure in conscious mice is essential in cardiovascular research. Telemetry, the \u201cgold\u2010standard\u201d technique, is invasive and expensive and therefore tail\u2010cuff, a noninvasive alternative, is widely used. However, tail\u2010cuff requires handling and restraint during measurement, which may cause stress affecting blood pressure and undermining reliability of the results.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              C57Bl\/6J mice were implanted with radio\u2010telemetry probes to investigate the effects of the steps of the tail\u2010cuff technique on central blood pressure, heart rate, and temperature. This included comparison of handling techniques, operator's sex, habituation, and influence of hypertension induced by angiotensin\n              <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n              . Direct comparison of measurements obtained by telemetry and tail\u2010cuff were made in the same mouse. The results revealed significant increases in central blood pressure, heart rate, and core body temperature from baseline following handling interventions without significant difference among the different handling technique, habituation, or sex of the investigator. Restraint induced the largest and sustained increase in cardiovascular parameters and temperature. The tail\u2010cuff readings significantly underestimated those from simultaneous telemetry recordings; however, \u201cnonsimultaneous\u201d telemetry, obtained in undisturbed mice, were similar to tail\u2010cuff readings obtained in undisturbed mice on the same day.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">This study reveals that the tail\u2010cuff technique underestimates the core blood pressure changes that occur simultaneously during the restraint and measurement phases. However, the measurements between the 2 techniques are similar when tail\u2010cuff readings are compared with telemetry readings in the nondisturbed mice. The differences between the simultaneous recordings by the 2 techniques should be recognized by researchers.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.116.005204","type":"journal-article","created":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T00:20:16Z","timestamp":1498609216000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":115,"title":["Tail\u2010Cuff Technique and Its Influence on Central Blood Pressure in the Mouse"],"prefix":"10.1161","volume":"6","author":[{"given":"Elena","family":"Wilde","sequence":"first","affiliation":[{"name":"Vascular Biology and Inflammation Section, BHF Cardiovascular Centre of Research Excellence, Cardiovascular Division, King's College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisah A.","family":"Aubdool","sequence":"additional","affiliation":[{"name":"Vascular Biology and Inflammation Section, BHF Cardiovascular Centre of Research Excellence, Cardiovascular Division, King's College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratish","family":"Thakore","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Division, King's College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Lineu","family":"Baldissera","sequence":"additional","affiliation":[{"name":"Vascular Biology and Inflammation Section, BHF Cardiovascular Centre of Research Excellence, Cardiovascular Division, King's College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadija M.","family":"Alawi","sequence":"additional","affiliation":[{"name":"Vascular Biology and Inflammation Section, BHF Cardiovascular Centre of Research Excellence, Cardiovascular Division, King's College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Keeble","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Division, King's College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manasi","family":"Nandi","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Division, King's College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan D.","family":"Brain","sequence":"additional","affiliation":[{"name":"Vascular Biology and Inflammation Section, BHF Cardiovascular Centre of Research Excellence, Cardiovascular Division, King's College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(05)80175-7"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2014.08.002"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2009.106"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00164.2002"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000150857.39919.cb"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00197.2016"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/026119290403201s28"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1258\/002367707782314328"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(02)00039-2"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2008.301"},{"key":"e_1_3_4_12_2","first-page":"42","article-title":"Laboratory routines cause animal stress","volume":"43","author":"Balcombe JP","year":"2004","unstructured":"Balcombe JP, Barnard ND, Sandusky C. 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