{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:56:46Z","timestamp":1791601006518,"version":"4.3.4"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The incidence, predictors, and impact of atrial arrhythmias along with left atrial structural changes in patients with left ventricular assist devices (\n              <jats:styled-content style=\"fixed-case\">LVAD<\/jats:styled-content>\n              s) remain undetermined.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              All patients who underwent\n              <jats:styled-content style=\"fixed-case\">LVAD<\/jats:styled-content>\n              implantation from 2008 to 2015 at the University of Chicago Medical Center were included. Electronic medical records, electrocardiograms, echocardiograms, and cardiac electrical device interrogations were reviewed. The association of arrhythmias and clinical covariates with survival was evaluated by Kaplan\u2013Meier and Cox proportional hazards analyses. A total of 331 patients were followed for a median of 330\u00a0days (range 0\u20132306 days). Mean age was 57.8\u00b112.8\u00a0years, 256 participants (77.3%) were male, mean left ventricular ejection fraction was 20\u00b16.6%, and 124 (37.5%) had ischemic cardiomyopathy. Atrial arrhythmias (53.8%) were highly prevalent and frequently coexisted before\n              <jats:styled-content style=\"fixed-case\">LVAD<\/jats:styled-content>\n              implantation: atrial fibrillation (\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              ) in 45.9%, atrial flutter in 13.9%, atrial tachycardia in 6.9%, and atrioventricular nodal reentrant tachycardia in 1.2%. New\u2010onset\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              was documented in 14 patients (7.8% of patients without prior\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              ) after the first 30\u00a0days with an\n              <jats:styled-content style=\"fixed-case\">LVAD<\/jats:styled-content>\n              . Increasing age, renal insufficiency, and lung disease were predictors of new\u2010onset\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              after LVAD implantation. Of patients with paroxysmal\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              , 43% had no further\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              after\n              <jats:styled-content style=\"fixed-case\">LVAD<\/jats:styled-content>\n              . Left atrial size and volume index improved with\n              <jats:styled-content style=\"fixed-case\">LVAD<\/jats:styled-content>\n              (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.005). History of persistent\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              , atrial tachycardia, ventricular arrhythmia, coronary artery bypass, and low albumin were associated with decreased survival.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Atrial arrhythmias are significantly prevalent in patients who require\n              <jats:styled-content style=\"fixed-case\">LVAD<\/jats:styled-content>\n              and are associated with increased mortality; however,\n              <jats:styled-content style=\"fixed-case\">LVAD<\/jats:styled-content>\n              s induce favorable atrial structural and electrical remodeling.\n            <\/jats:p>\n          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