{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:16:08Z","timestamp":1789694168680,"version":"4.0.1"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The aim was to assess whether cardiovascular adaptation to pregnancy in women with repaired tetralogy of Fallot (\n              <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>\n              ) adversely affects hemodynamic stability, in particular with respect to right ventricular (\n              <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\n              ) dilatation, pulmonary regurgitation, or aortic root dilatation.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This was a retrospective cohort study of women with repaired\n              <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>\n              with paired cardiovascular magnetic resonance scans before and after their first pregnancy (baseline\n              <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\n              end systolic volume index 49\u00a0mL\/m\n              <jats:sup>2<\/jats:sup>\n              and\n              <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\n              end diastolic volume index 118\u00a0mL\/m\n              <jats:sup>2<\/jats:sup>\n              ) matched with a comparison group of nulliparous women with\n              <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>\n              . Cases were matched for age at baseline cardiovascular magnetic resonance scan, time between follow\u2010up of cardiovascular magnetic resonance scans,\n              <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content>\n              duration,\n              <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\n              ejection fraction, and indexed\n              <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\n              end systolic and diastolic volume at baseline. Effect of pregnancy and time on parameters was assessed using mixed\u2010effects modelling. Nineteen women with repaired\n              <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>\n              who had completed their first pregnancy were identified and matched with 38 nulliparous women. We observed no deleterious effects of pregnancy on\n              <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\n              volumes, aortic dimensions, or exercise data. There was an effect of pregnancy observed in both left ventricular end diastolic volume and left ventricular stroke volume, consistent with a sustained small increase in left ventricular stroke volume attributed to pregnancy (53\u201355\u00a0mL\/m\n              <jats:sup>2<\/jats:sup>\n              ).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Women with repaired\n              <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>\n              and with mild\u2010to\u2010moderate\n              <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\n              dilatation considering pregnancy can be reassured that pregnancy is unlikely to cause deterioration in their cardiovascular status. We recommend that women are routinely assessed and followed up before and after pregnancy and that prepregnancy counseling is tailored to their individual clinical status.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.116.005420","type":"journal-article","created":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T00:10:16Z","timestamp":1500855016000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Effect of Pregnancy on Ventricular and Aortic Dimensions in Repaired Tetralogy of Fallot"],"prefix":"10.1161","volume":"6","author":[{"given":"Matthew","family":"Cauldwell","sequence":"first","affiliation":[{"name":"Academic Department of Obstetrics and Gynaecology, Imperial College London, United Kingdom"},{"name":"Adult Congenital Heart Centre, The National Heart and Lung Institute Imperial College London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Quail","sequence":"additional","affiliation":[{"name":"NIHR Cardiovascular Biomedical Research Unit, Royal Brompton Hospital Imperial College London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian S.","family":"Smith","sequence":"additional","affiliation":[{"name":"NIHR Cardiovascular Biomedical Research Unit, Royal Brompton Hospital Imperial College London, United Kingdom"},{"name":"Chelsea and Westminster Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ee Ling","family":"Heng","sequence":"additional","affiliation":[{"name":"NIHR Cardiovascular Biomedical Research Unit, Royal Brompton Hospital Imperial College London, United Kingdom"},{"name":"Chelsea and Westminster Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Ghonim","sequence":"additional","affiliation":[{"name":"NIHR Cardiovascular Biomedical Research Unit, Royal Brompton Hospital Imperial College London, United Kingdom"},{"name":"Chelsea and Westminster Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anselm","family":"Uebing","sequence":"additional","affiliation":[{"name":"NIHR Cardiovascular Biomedical Research Unit, Royal Brompton Hospital Imperial College London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorna","family":"Swan","sequence":"additional","affiliation":[{"name":"NIHR Cardiovascular Biomedical Research Unit, Royal Brompton Hospital Imperial College London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"NIHR Cardiovascular Biomedical Research Unit, Royal Brompton Hospital Imperial College London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshni R.","family":"Patel","sequence":"additional","affiliation":[{"name":"Academic Department of Obstetrics and Gynaecology, Imperial College London, United Kingdom"},{"name":"Adult Congenital Heart Centre, The National Heart and Lung Institute Imperial College London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dudley J.","family":"Pennell","sequence":"additional","affiliation":[{"name":"NIHR Cardiovascular Biomedical Research Unit, Royal Brompton Hospital Imperial College London, United Kingdom"},{"name":"Chelsea and Westminster Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Steer","sequence":"additional","affiliation":[{"name":"Academic Department of Obstetrics and Gynaecology, Imperial College London, United Kingdom"},{"name":"Adult Congenital Heart Centre, The National Heart and Lung Institute Imperial College London, United 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