{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:25:43Z","timestamp":1784647543557,"version":"3.55.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,12,2]]},"abstract":"\n Background<\/jats:title>\n \n Different sleep\u2010disordered breathing (\n SDB<\/jats:styled-content>\n ) phenotypes, including coexisting obstructive and central sleep apnea (\n OSA<\/jats:styled-content>\n \u2010\n CSA<\/jats:styled-content>\n ), have not yet been characterized in a large sample of patients with heart failure and reduced ejection fraction (\n HF<\/jats:styled-content>\n r\n EF<\/jats:styled-content>\n ) receiving guideline\u2010based therapies. Therefore, the aim of the present study was to determine the proportion of\n OSA<\/jats:styled-content>\n ,\n CSA<\/jats:styled-content>\n , and\n OSA<\/jats:styled-content>\n \u2010\n CSA<\/jats:styled-content>\n , as well as periodic breathing, in\n HF<\/jats:styled-content>\n r\n EF<\/jats:styled-content>\n patients with\n SDB<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n The German Schla\n HF<\/jats:styled-content>\n registry enrolled patients with\n HF<\/jats:styled-content>\n r\n EF<\/jats:styled-content>\n receiving guideline\u2010based therapies, who underwent portable\n SDB<\/jats:styled-content>\n monitoring. Polysomnography (n=2365) was performed in patients with suspected\n SDB<\/jats:styled-content>\n . Type of\n SDB<\/jats:styled-content>\n (\n OSA<\/jats:styled-content>\n ,\n CSA<\/jats:styled-content>\n , or\n OSA<\/jats:styled-content>\n \u2010\n CSA<\/jats:styled-content>\n ), the occurrence of periodic breathing (proportion of Cheyne\u2010Stokes respiration \u226520%), and blood gases were determined in 1557\n HF<\/jats:styled-content>\n r\n EF<\/jats:styled-content>\n patients with confirmed\n SDB<\/jats:styled-content>\n .\n OSA<\/jats:styled-content>\n ,\n OSA<\/jats:styled-content>\n \u2010\n CSA<\/jats:styled-content>\n , and\n CSA<\/jats:styled-content>\n were found in 29%, 40%, and 31% of patients, respectively; 41% showed periodic breathing. Characteristics differed significantly among\n SDB<\/jats:styled-content>\n groups and in those with versus without periodic breathing. There was a relationship between greater proportions of\n CSA<\/jats:styled-content>\n and the presence of periodic breathing. Risk factors for having\n CSA<\/jats:styled-content>\n rather than\n OSA<\/jats:styled-content>\n were male sex, older age, presence of atrial fibrillation, lower ejection fraction, and lower awake carbon dioxide pressure (\n pco<\/jats:sc>\n 2<\/jats:sub>\n ). Periodic breathing was more likely in men, patients with atrial fibrillation, older patients, and as left ventricular ejection fraction and awake\n pco<\/jats:sc>\n 2<\/jats:sub>\n decreased, and less likely as body mass index increased and minimum oxygen saturation decreased.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Schla\n HF<\/jats:styled-content>\n data show that there is wide interindividual variability in the\n SDB<\/jats:styled-content>\n phenotype of\n HF<\/jats:styled-content>\n r\n EF<\/jats:styled-content>\n patients, suggesting that individualized management is appropriate.\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n URL<\/jats:styled-content>\n :\n https:\/\/www.clinicaltrials.gov\/<\/jats:ext-link>\n . Unique identifier:\n NCT<\/jats:styled-content>\n 01500759.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.116.005899","type":"journal-article","created":{"date-parts":[[2017,11,30]],"date-time":"2017-11-30T01:10:10Z","timestamp":1512004210000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":74,"title":["Phenotyping of Sleep\u2010Disordered Breathing in Patients With Chronic Heart Failure With Reduced Ejection Fraction\u2014the SchlaHF Registry"],"prefix":"10.1161","volume":"6","author":[{"given":"Michael","family":"Arzt","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II, University Hospital Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Oldenburg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart and Diabetes Center North Rhine\u2010Westphalia, Bad Oeynhausen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Graml","sequence":"additional","affiliation":[{"name":"ResMed Science Center, Martinsried, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erland","family":"Erdmann","sequence":"additional","affiliation":[{"name":"Clinic III for Internal Medicine, Heart Center University Hospital Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Teschler","sequence":"additional","affiliation":[{"name":"Department of Pneumology, Ruhrlandklinik, West German Lung Center, University Hospital Essen University Duisburg\u2010Essen, Duisburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Wegscheider","sequence":"additional","affiliation":[{"name":"Department of Medical Biometry and Epidemiology, University Medical Center Hamburg\u2010Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Suling","sequence":"additional","affiliation":[{"name":"Department of Medical Biometry and Epidemiology, University Medical Center Hamburg\u2010Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Woehrle","sequence":"additional","affiliation":[{"name":"ResMed Science Center, Martinsried, Germany"},{"name":"Sleep and Ventilation Center Blaubeuren, Respiratory Center Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the SchlaHF Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.07.046"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.025270"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01700-4"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31823ac046"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.300268"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs104"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2006.08.003"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00037106"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2015.09.014"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00070509"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq327"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.1.8542128"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.01.084"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.11.1435"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.12.046"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2008.11.015"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201205-0894OC"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506459"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.12.068"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.21.2154"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.1.61"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.2.238"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-14-46"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi204"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.2172"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.2450"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1586\/17476348.2015.1019478"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606599"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.116.005899","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:42:58Z","timestamp":1715596978000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.116.005899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,2]]},"references-count":28,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12,2]]}},"alternative-id":["10.1161\/JAHA.116.005899"],"URL":"https:\/\/doi.org\/10.1161\/jaha.116.005899","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,2]]},"assertion":[{"value":"2017-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e005899"}}