{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:58:37Z","timestamp":1792659517302,"version":"4.5.0"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,8,2]]},"abstract":"<jats:sec xml:lang=\"en\"><jats:title>Background<\/jats:title><jats:p xml:lang=\"en\">We examined the role of menopause on cardiac dimensions and function and assessed the efficacy of exercise training before and after menopause.<\/jats:p><\/jats:sec><jats:sec xml:lang=\"en\"><jats:title>Methods and Results<\/jats:title><jats:p xml:lang=\"en\">Two groups of healthy premenopausal (n=36, 49.4\u00b10.3\u00a0years) and postmenopausal (n=37, 53.5\u00b10.5\u00a0years) women with no history of cardiovascular disease and with a mean age difference between groups of only 4\u00a0years were studied. Cardiac dimensions and systolic and diastolic function were determined by transthoracic echocardiography with tissue Doppler imaging and 2\u2010dimensional speckle tracking. Measurements were performed at baseline and after a 12\u2010week period of high\u2010intensity aerobic cycle training. LV internal diastolic diameter and LV mass were similar in the 2 groups at baseline and increased by \u22482% to 8% (<jats:italic>P<\/jats:italic>=0.04\u20130.0007) with training in both groups. Left atrial end\u2010diastolic and end\u2010systolic volumes were similar for both groups and increased by 23% to 36% (<jats:italic>P=<\/jats:italic>0.0006\u20130.0001) with training. Systolic function assessed by mean global strain was similar in both groups at baseline and increased by \u22488% (<jats:italic>P<\/jats:italic>=0.0004) with training in the postmenopausal group. LV displacement increased by \u22483% (<jats:italic>P<\/jats:italic>=0.04) in the premenopausal women only. Diastolic function assessed by E\/A ratio was similar at baseline and increased by \u22487% (<jats:italic>P<\/jats:italic>=0.01) in the premenopausal group and 11% (<jats:italic>P<\/jats:italic>=0.0001) in the postmenopausal group with training.<\/jats:p><\/jats:sec><jats:sec xml:lang=\"en\"><jats:title>Conclusions<\/jats:title><jats:p xml:lang=\"en\">These results suggest that training\u2010induced cardiac adaptations are preserved in the early postmenopausal phase. Furthermore, the hormonal changes associated with the menopausal transition do not appear to affect cardiac dimensions and function.<\/jats:p><\/jats:sec><jats:sec xml:lang=\"en\"><jats:title>Clinical Trial Registration<\/jats:title><jats:p xml:lang=\"en\">URL:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>. Unique identifier: NCT02135575.<\/jats:p><\/jats:sec>","DOI":"10.1161\/jaha.117.005469","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T18:25:38Z","timestamp":1504290338000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":27,"title":["Cardiac Adaptations to High\u2010Intensity Aerobic Training in Premenopausal and Recent Postmenopausal Women: The Copenhagen Women Study"],"prefix":"10.1161","volume":"6","author":[{"given":"Jon","family":"Egelund","sequence":"first","affiliation":[{"name":"Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Gentofte Hospital, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla M.","family":"Mandrup","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Fritz\u2010Hansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Gentofte Hospital, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bente","family":"Stallknecht","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Bangsbo","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Nyberg","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ylva","family":"Hellsten","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.1.583"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.307547"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-016-0073-y"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5170"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00165"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2244"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.116.07866"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2012.11.019"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2015.11.014"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365516909080169"},{"key":"e_1_3_3_12_2","first-page":"233","article-title":"Maximal oxygen uptake in young women with training, inactivity, and retraining","volume":"10","author":"Pedersen PK","year":"1978","unstructured":"Pedersen PK, Jorgensen K. 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