{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:32:09Z","timestamp":1793370729482,"version":"4.5.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,4,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      In peripartum cardiomyopathy, the prevalence of focal myocardial damage detected by late gadolinium enhancement (\n                      <jats:styled-content style=\"fixed-case\">LGE<\/jats:styled-content>\n                      ) cardiovascular magnetic resonance is important to elucidate mechanisms of myocardial injury and cardiac dysfunction.\n                      <jats:styled-content style=\"fixed-case\">LGE<\/jats:styled-content>\n                      equates irreversible myocardial injury, but\n                      <jats:styled-content style=\"fixed-case\">LGE<\/jats:styled-content>\n                      prevalence in peripartum cardiomyopathy is uncertain.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among 100 women enrolled within the Investigations of Pregnancy Associated Cardiomyopathy cohort, we recruited 40 women at 13 centers to undergo\n                      <jats:styled-content style=\"fixed-case\">LGE<\/jats:styled-content>\n                      cardiovascular magnetic resonance, enrolled within the first 13\u00a0weeks postpartum. Follow\u2010up scans occurred at 6\u00a0months postpartum, and death\/transplant rates at 12\u00a0months. Baseline characteristics did not differ significantly in the parent cohort according to cardiovascular magnetic resonance enrollment except for mechanical circulatory support.\n                      <jats:styled-content style=\"fixed-case\">LGE<\/jats:styled-content>\n                      was noted only in 2 women (5%) at baseline. While left ventricular dysfunction with enlargement was prevalent at baseline cardiovascular magnetic resonance scans (eg, ejection fraction 38% [Q1\u2013Q3 31\u201350%], end diastolic volume index=108\u00a0mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      [Q1\u2013Q3 83\u2013134 mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      ]), most women demonstrated significant improvements at 6\u00a0months, consistent with a low prevalence of\n                      <jats:styled-content style=\"fixed-case\">LGE<\/jats:styled-content>\n                      .\n                      <jats:styled-content style=\"fixed-case\">LGE<\/jats:styled-content>\n                      was not related to baseline clinical variables, ejection fraction, New York Heart Association heart failure class, or mortality. Neither of the 2 women who died exhibited\n                      <jats:styled-content style=\"fixed-case\">LGE<\/jats:styled-content>\n                      .\n                      <jats:styled-content style=\"fixed-case\">LGE<\/jats:styled-content>\n                      was inversely associated with persistent left ventricular ejection fraction at 6\u00a0months (\n                      <jats:italic>P<\/jats:italic>\n                      =0.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Factors other than focal myocardial damage detectable by\n                      <jats:styled-content style=\"fixed-case\">LGE<\/jats:styled-content>\n                      explain the initial transient depressions in baseline left ventricular ejection fraction, yet focal myocardial damage may contribute to persistent myocardial dysfunction and hinder recovery in a small minority. Most women exhibit favorable changes in ventricular function over 6\u00a0months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      <jats:styled-content style=\"fixed-case\">URL<\/jats:styled-content>\n                      :\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      . Unique identifier:\n                      <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>\n                      01085955.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.117.005472","type":"journal-article","created":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T20:13:21Z","timestamp":1491250401000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":63,"title":["Myocardial Damage Detected by Late Gadolinium Enhancement Cardiac Magnetic Resonance Is Uncommon in Peripartum Cardiomyopathy"],"prefix":"10.1161","volume":"6","author":[{"given":"Erik B.","family":"Schelbert","sequence":"first","affiliation":[{"name":"University of Pittsburgh Medical Center, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uri","family":"Elkayam","sequence":"additional","affiliation":[{"name":"University of Southern California, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie T.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Jacksonville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"Givertz","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Alexis","sequence":"additional","affiliation":[{"name":"University of Rochester School of Medicine and Dentistry, Rochester, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Briller","sequence":"additional","affiliation":[{"name":"University of Illinois, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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