{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T23:56:30Z","timestamp":1794009390792,"version":"4.8.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,8,2]]},"abstract":"\n Background<\/jats:title>\n \n Sudden cardiac death (\n SCD<\/jats:styled-content>\n ) is often the first presentation of ischemic heart disease; however, there is limited information on\n SCD<\/jats:styled-content>\n among women with and without obstructive coronary artery disease (\n CAD<\/jats:styled-content>\n ). We evaluated\n SCD<\/jats:styled-content>\n incidence in the WISE (Women's Ischemia Syndrome Evaluation) study.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Overall, 904 women with suspected ischemic heart disease with preserved ejection fraction and core laboratory coronary angiography were followed for outcomes. In case of death, a death certificate and\/or a physician or family narrative of the circumstances of death was obtained. A clinical events committee rated all deaths as cardiovascular or noncardiovascular and as\n SCD<\/jats:styled-content>\n or non\u2010\n SCD<\/jats:styled-content>\n . In total, 96 women (11%) died over a median of 6 years (maximum: 8 years). Among 65 cardiovascular deaths, 42% were\n SCD<\/jats:styled-content>\n . Mortality per 1000\u00a0person\u2010hours increased linearly with\n CAD<\/jats:styled-content>\n severity (no\n CAD<\/jats:styled-content>\n : 5.8; minimal: 15.9; obstructive: 38.6;\n P<\/jats:italic>\n <0.0001). However, the proportion of\n SCD<\/jats:styled-content>\n was similar across\n CAD<\/jats:styled-content>\n severity: 40%, 58%, and 38% for no, minimal, and obstructive\n CAD<\/jats:styled-content>\n subgroups, respectively (\n P<\/jats:italic>\n value not significant). In addition to traditional risk factors (age, diabetes mellitus, smoking), a history of depression (\n P<\/jats:italic>\n =0.018) and longer corrected QT interval (\n P<\/jats:italic>\n =0.023) were independent\n SCD<\/jats:styled-content>\n predictors in the entire cohort. Corrected QT interval was an independent predictor of\n SCD<\/jats:styled-content>\n in women without obstructive\n CAD<\/jats:styled-content>\n (\n P<\/jats:italic>\n =0.033).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n SCD<\/jats:styled-content>\n contributes substantially to mortality in women with and without obstructive\n CAD<\/jats:styled-content>\n . Corrected QT interval is the single independent\n SCD<\/jats:styled-content>\n risk factor in women without obstructive\n CAD<\/jats:styled-content>\n . In addition to management of traditional risk factors, these data indicate that further investigation should address mechanistic understanding and interventions targeting depression and corrected QT interval in women.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.005501","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T18:25:38Z","timestamp":1504290338000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["Sudden Cardiac Death in Women With Suspected Ischemic Heart Disease, Preserved Ejection Fraction, and No Obstructive Coronary Artery Disease: A Report From the Women's Ischemia Syndrome Evaluation Study"],"prefix":"10.1161","volume":"6","author":[{"given":"Puja K.","family":"Mehta","sequence":"first","affiliation":[{"name":"Emory University School of Medicine, Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Delia","family":"Johnson","sequence":"additional","affiliation":[{"name":"Graduate School of Public Health, University of Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya S.","family":"Kenkre","sequence":"additional","affiliation":[{"name":"Graduate School of Public Health, University of Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wafia","family":"Eteiba","sequence":"additional","affiliation":[{"name":"Graduate School of Public Health, University of Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Sharaf","sequence":"additional","affiliation":[{"name":"Rhode Island Hospital, Providence, RI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl J.","family":"Pepine","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven E.","family":"Reis","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Medical Center, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Rogers","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryl F.","family":"Kelsey","sequence":"additional","affiliation":[{"name":"Graduate School of Public Health, University of Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane V.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Allegheny General Hospital, Pittsburgh, PA"},{"name":"National Institutes of Health, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Bittner","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Sopko","sequence":"additional","affiliation":[{"name":"Allegheny General Hospital, Pittsburgh, PA"},{"name":"National Institutes of Health, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslee J.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine, Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Noel","family":"Bairey Merz","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine, Atlanta, GA"},{"name":"Cedars Sinai Heart Institute, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000065223.21530.11"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2008.06.003"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.09.064"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.023846"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc4301.098254"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.06.029"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3909\/ricm0589"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.07.038"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2009.10.019"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.107.181940"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2001.114198"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.026542"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.098"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.08.876"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.007149"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv456"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.11.045"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00082-0"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.01.054"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2013.04.002"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)01424-2"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.08.067"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.797035"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.80.5.1301"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.328"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2013.03.001"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.psy.0000146795.38162.b1"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.psy.0000228342.53606.b3"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.2.195"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.10.060"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.176040"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000115525.92645.16"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs411"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.117.005501","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:51:45Z","timestamp":1715597505000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.117.005501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,2]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8,2]]}},"alternative-id":["10.1161\/JAHA.117.005501"],"URL":"https:\/\/doi.org\/10.1161\/jaha.117.005501","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,2]]},"assertion":[{"value":"2017-01-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-08-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e005501"}}