{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:57:22Z","timestamp":1785391042007,"version":"3.55.0"},"reference-count":52,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,5]]},"abstract":"\n Background<\/jats:title>\n \n Remote ischemic conditioning (\n RIC<\/jats:styled-content>\n ) is a noninvasive therapeutic strategy that uses brief cycles of blood pressure cuff inflation and deflation to protect the myocardium against ischemia\u2013reperfusion injury. The objective of this systematic review was to determine the impact of\n RIC<\/jats:styled-content>\n on myocardial salvage index, infarct size, and major adverse cardiovascular events when initiated before catheterization.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Electronic searches of Medline, Embase, and Cochrane Central Register of Controlled Trials were conducted and reference lists were hand searched. Randomized controlled trials comparing percutaneous coronary intervention (\n PCI<\/jats:styled-content>\n ) with and without\n RIC<\/jats:styled-content>\n for patients with ST\u2010segment\u2013elevation myocardial infarction were included. Two reviewers independently screened abstracts, assessed quality of the studies, and extracted data. Data were pooled using random\u2010effects models and reported as mean differences and relative risk with 95% confidence intervals. Eleven articles (9 randomized controlled trials) were included with a total of 1220 patients (\n RIC<\/jats:styled-content>\n +\n PCI<\/jats:styled-content>\n =643,\n PCI<\/jats:styled-content>\n =577). Studies with no events were excluded from meta\u2010analysis. The myocardial salvage index was higher in the\n RIC<\/jats:styled-content>\n +\n PCI<\/jats:styled-content>\n group compared with the\n PCI<\/jats:styled-content>\n group (mean difference: 0.08; 95% confidence interval, 0.02\u20130.14). Infarct size was reduced in the\n RIC<\/jats:styled-content>\n +\n PCI<\/jats:styled-content>\n group compared with the\n PCI<\/jats:styled-content>\n group (mean difference: \u22122.46; 95% confidence interval, \u22124.66 to \u22120.26). Major adverse cardiovascular events were lower in the\n RIC<\/jats:styled-content>\n +\n PCI<\/jats:styled-content>\n group (9.5%) compared with the\n PCI<\/jats:styled-content>\n group (17.0%; relative risk: 0.57; 95% confidence interval, 0.40\u20130.82).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n RIC<\/jats:styled-content>\n appears to be a promising adjunctive treatment to\n PCI<\/jats:styled-content>\n for the prevention of reperfusion injury in patients with ST\u2010segment\u2013elevation myocardial infarction; however, additional high\u2010quality research is required before a change in practice can be considered.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.005522","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T20:20:16Z","timestamp":1495052416000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":58,"title":["Remote Ischemic Perconditioning to Reduce Reperfusion Injury During Acute ST\u2010Segment\u2013Elevation Myocardial Infarction: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1161","volume":"6","author":[{"given":"Shelley L.","family":"McLeod","sequence":"first","affiliation":[{"name":"University of Toronto","place":["Canada"]},{"name":"Mount Sinai Hospital","place":["Toronto, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alla","family":"Iansavichene","sequence":"additional","affiliation":[{"name":"London Health Sciences Centre","place":["London, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheldon","family":"Cheskes","sequence":"additional","affiliation":[{"name":"University of Toronto","place":["Canada"]},{"name":"Sunnybrook Centre for Prehospital Medicine","place":["Toronto, Canada"]},{"name":"St. Michael's Hospital","place":["Toronto, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","first-page":"893","article-title":"Outcomes of acute myocardial infarction in Canada","volume":"19","author":"Tu JV","year":"2003","unstructured":"Tu JV, Austin PC, Filate WA, Johansen HL, Brien SE, Pilote L, Alter DA; Canadian Cardiovascular Outcomes Research Team . 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