{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:05:00Z","timestamp":1768781100675,"version":"3.49.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,9,22]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              High aortic stiffness has been shown to be a strong predictor of morbidity and mortality in the general population and several patient cohorts. However, in patients after\n              <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\n              \u2010elevation myocardial infarction, the prognostic value of high aortic stiffness is unknown so far.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This prospective observational study included 160 consecutive patients with first acute\n              <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\n              \u2010elevation myocardial infarction. Aortic pulse wave velocity (\n              <jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content>\n              ) was measured 2 (interquartile range 2\u20104\u00a0days) days after infarction using cardiac magnetic resonance imaging. The primary end point was defined as a composite end point of major adverse cardiac and cerebrovascular events (\n              <jats:styled-content style=\"fixed-case\">MACCE<\/jats:styled-content>\n              ) comprising death, nonfatal myocardial reinfarction, new congestive heart failure, and stroke. During a median follow\u2010up of 1.2\u00a0years (interquartile range 1.0\u20103.1\u00a0years), 19 (12%)\n              <jats:styled-content style=\"fixed-case\">MACCE<\/jats:styled-content>\n              events occurred. Kaplan\u2010Meier analysis showed a significantly lower\n              <jats:styled-content style=\"fixed-case\">MACCE<\/jats:styled-content>\n              \u2010free survival in patients with high\n              <jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content>\n              (\n              <jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content>\n              &gt;7.3\u00a0m\/s, log\u2010rank\n              <jats:italic>P<\/jats:italic>\n              =0.003). Multivariable Cox regression analysis revealed\n              <jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content>\n              &gt;7.3\u00a0m\/s to be an independent predictor of\n              <jats:styled-content style=\"fixed-case\">MACCE<\/jats:styled-content>\n              after adjustment for age, sex, mean blood pressure, N\u2010terminal pro\u2013brain natriuretic peptide levels, presence of multivessel disease, and left ventricular stroke volume (hazard ratios \u22653.5; 95% confidence interval 1.4\u201013.3; all\n              <jats:italic>P<\/jats:italic>\n              \u22640.018). In reclassification analysis the addition of\n              <jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content>\n              to a risk model comprising major clinical prognostic parameters led to a net reclassification improvement of 0.11 (95% confidence interval 0.06\u20100.17;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Increased aortic stiffness is an independent predictor of\n              <jats:styled-content style=\"fixed-case\">MACCE<\/jats:styled-content>\n              after acute\n              <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\n              \u2010elevation myocardial infarction. Moreover, the assessment of aortic stiffness in addition to classical risk factors significantly improved early risk stratification.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.005590","type":"journal-article","created":{"date-parts":[[2017,9,9]],"date-time":"2017-09-09T00:10:30Z","timestamp":1504915830000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":30,"title":["Prognostic Value of Aortic Stiffness in Patients After ST\u2010Elevation Myocardial Infarction"],"prefix":"10.1161","volume":"6","author":[{"given":"Hans\u2010Josef","family":"Feistritzer","sequence":"first","affiliation":[{"name":"University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gert","family":"Klug","sequence":"additional","affiliation":[{"name":"University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian J.","family":"Reinstadler","sequence":"additional","affiliation":[{"name":"University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Reindl","sequence":"additional","affiliation":[{"name":"University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lea","family":"Niess","sequence":"additional","affiliation":[{"name":"University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Nalbach","sequence":"additional","affiliation":[{"name":"University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Kremser","sequence":"additional","affiliation":[{"name":"University Clinic of Radiology, Medical University of Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnes","family":"Mayr","sequence":"additional","affiliation":[{"name":"University Clinic of Radiology, Medical University of Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Metzler","sequence":"additional","affiliation":[{"name":"University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, 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