{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:52:35Z","timestamp":1789987955035,"version":"4.0.1"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,5]]},"abstract":"\n Background<\/jats:title>\n \n Impaired orthostatic blood pressure (\n BP<\/jats:styled-content>\n ) stabilization is highly prevalent in older adults and is a predictor of end\u2010organ injury, falls, and mortality. We sought to characterize the relationship between postural\n BP<\/jats:styled-content>\n responses and the kidney.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We performed a cross\u2010sectional analysis of 4204 participants from The Irish Longitudinal Study on Ageing, a national cohort of community\u2010dwelling adults aged \u226550\u00a0years. Beat\u2010to\u2010beat systolic and diastolic\n BP<\/jats:styled-content>\n were measured during a 2\u2010minute active stand test. The primary predictor was cystatin C estimated glomerular filtration rate (\n eGFR<\/jats:styled-content>\n ) categorized as follows (mL\/min per 1.73\u00a0m\n 2<\/jats:sup>\n ): \u226590 (reference, n=1414); 75 to 89 (n=1379); 60 to 74 (n=942); 45 to 59 (n=337); <45 (n=132). We examined the association between\n eGFR<\/jats:styled-content>\n categories and (1) sustained orthostatic hypotension, defined as a\n BP<\/jats:styled-content>\n drop exceeding consensus thresholds (systolic\n BP<\/jats:styled-content>\n drop \u226520\u00a0mm\u00a0Hg\u00b1diastolic\n BP<\/jats:styled-content>\n drop \u226510\u00a0mm\u00a0Hg) at each 10\u2010second interval from 60 to 110\u00a0seconds inclusive; (2) pattern of\n BP<\/jats:styled-content>\n stabilization, characterized as the difference from baseline in mean systolic\n BP<\/jats:styled-content>\n \/diastolic\n BP<\/jats:styled-content>\n at 10\u2010second intervals. The mean age of subjects was 61.6\u00a0years; 47% of subjects were male, and the median\n eGFR<\/jats:styled-content>\n was 82\u00a0mL\/min per\u00a01.73\u00a0m\n 2<\/jats:sup>\n . After multivariable adjustment, participants with\n eGFR<\/jats:styled-content>\n <60\u00a0mL\/min per 1.73\u00a0m\n 2<\/jats:sup>\n were approximately twice as likely to have sustained orthostatic hypotension (\n P<\/jats:italic>\n =0.008 for trend across\n eGFR<\/jats:styled-content>\n categories). We observed a graded association between\n eGFR<\/jats:styled-content>\n categories and impaired orthostatic\n BP<\/jats:styled-content>\n stabilization, particularly within the first minute of standing.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n We report a novel, graded relationship between diminished\n eGFR<\/jats:styled-content>\n and impaired orthostatic\n BP<\/jats:styled-content>\n stabilization. Mapping the postural\n BP<\/jats:styled-content>\n response merits further study in kidney disease as a potential means of identifying those at risk of hypotension\u2010related events.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.005661","type":"journal-article","created":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T20:25:39Z","timestamp":1493929539000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Graded Association Between Kidney Function and Impaired Orthostatic Blood Pressure Stabilization in Older Adults"],"prefix":"10.1161","volume":"6","author":[{"given":"Mark","family":"Canney","sequence":"first","affiliation":[{"name":"Trinity College Dublin","place":["Dublin 2, Ireland"]},{"name":"Tallaght Hospital","place":["Dublin 24, Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D. L.","family":"O'Connell","sequence":"additional","affiliation":[{"name":"Trinity College Dublin","place":["Dublin 2, Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donal J.","family":"Sexton","sequence":"additional","affiliation":[{"name":"Trinity College Dublin","place":["Dublin 2, Ireland"]},{"name":"Tallaght Hospital","place":["Dublin 24, Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"O'Leary","sequence":"additional","affiliation":[{"name":"Trinity College Dublin","place":["Dublin 2, Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose Anne","family":"Kenny","sequence":"additional","affiliation":[{"name":"Trinity College Dublin","place":["Dublin 2, Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Little","sequence":"additional","affiliation":[{"name":"Tallaght Hospital","place":["Dublin 24, Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conall M.","family":"O'Seaghdha","sequence":"additional","affiliation":[{"name":"Beaumont Hospital","place":["Dublin 9, Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.7326\/0003-4819-159-4-201308200-00004","article-title":"Blood pressure and mortality in U.S. veterans with chronic kidney disease: a cohort study","volume":"159","author":"Kovesdy CP","year":"2013","unstructured":"Kovesdy CP, Bleyer AJ, Molnar MZ, Ma JZ, Sim JJ, Cushman WC, Quarles LD, Kalantar\u2010Zadeh K. Blood pressure and mortality in U.S. veterans with chronic kidney disease: a cohort study. Ann Intern Med. 2013;159:233\u2013242.","journal-title":"Ann Intern Med"},{"key":"e_1_3_1_3_2","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.2215\/CJN.11391114","article-title":"Systolic BP and mortality in older adults with CKD","volume":"10","author":"Weiss JW","year":"2015","unstructured":"Weiss JW, Peters D, Yang X, Petrik A, Smith DH, Johnson ES, Thorp ML, Morris C, O'Hare AM. Systolic BP and mortality in older adults with CKD. Clin J Am Soc Nephrol. 2015;10:1553\u20131559.","journal-title":"Clin J Am Soc Nephrol"},{"key":"e_1_3_1_4_2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/eurheartj\/ehp329","article-title":"Orthostatic hypotension predicts all\u2010cause mortality and coronary events in middle\u2010aged individuals (The Malmo Preventive Project)","volume":"31","author":"Fedorowski A","year":"2010","unstructured":"Fedorowski A, Stavenow L, Hedblad B, Berglund G, Nilsson PM, Melander O. Orthostatic hypotension predicts all\u2010cause mortality and coronary events in middle\u2010aged individuals (The Malmo Preventive Project). Eur Heart J. 2010;31:85\u201391.","journal-title":"Eur Heart J"},{"key":"e_1_3_1_5_2","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/ajh.2010.150","article-title":"Orthostatic hypotension predicts incidence of heart failure: the Malmo preventive project","volume":"23","author":"Fedorowski A","year":"2010","unstructured":"Fedorowski A, Engstrom G, Hedblad B, Melander O. Orthostatic hypotension predicts incidence of heart failure: the Malmo preventive project. Am J Hypertens. 2010;23:1209\u20131215.","journal-title":"Am J Hypertens"},{"key":"e_1_3_1_6_2","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1161\/01.STR.31.10.2307","article-title":"Orthostatic hypotension as a risk factor for stroke: the Atherosclerosis Risk in Communities (ARIC) Study, 1987\u20131996","volume":"31","author":"Eigenbrodt ML","year":"2000","unstructured":"Eigenbrodt ML, Rose KM, Couper DJ, Arnett DK, Smith R, Jones D. Orthostatic hypotension as a risk factor for stroke: the Atherosclerosis Risk in Communities (ARIC) Study, 1987\u20131996. Stroke. 2000;31:2307\u20132313.","journal-title":"Stroke"},{"key":"e_1_3_1_7_2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10286-011-0119-5","article-title":"Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome","volume":"21","author":"Freeman R","year":"2011","unstructured":"Freeman R, Wieling W, Axelrod FB, Benditt DG, Benarroch E, Biaggioni I, Cheshire WP, Chelimsky T, Cortelli P, Gibbons CH, Goldstein DS, Hainsworth R, Hilz MJ, Jacob G, Kaufmann H, Jordan J, Lipsitz LA, Levine BD, Low PA, Mathias C, Raj SR, Robertson D, Sandroni P, Schatz I, Schondorff R, Stewart JM, van Dijk JG. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res. 2011;21:69\u201372.","journal-title":"Clin Auton Res"},{"key":"e_1_3_1_8_2","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1161\/CIRCULATIONAHA.114.009831","article-title":"Age\u2010related normative changes in phasic orthostatic blood pressure in a large population study: findings from the Irish Longitudinal Study on Ageing (TILDA)","volume":"130","author":"Finucane C","year":"2014","unstructured":"Finucane C, O'Connell MD, Fan CW, Savva GM, Soraghan CJ, Nolan H, Cronin H, Kenny RA. Age\u2010related normative changes in phasic orthostatic blood pressure in a large population study: findings from the Irish Longitudinal Study on Ageing (TILDA). Circulation. 2014;130:1780\u20131789.","journal-title":"Circulation"},{"key":"e_1_3_1_9_2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/MBP.0b013e3280b083bd","article-title":"Measuring orthostatic hypotension with the Finometer device: is a blood pressure drop of one heartbeat clinically relevant?","volume":"12","author":"van der Velde N","year":"2007","unstructured":"van der Velde N, van den Meiracker AH, Stricker BH, van der Cammen TJ. Measuring orthostatic hypotension with the Finometer device: is a blood pressure drop of one heartbeat clinically relevant? Blood Press Monit. 2007;12:167\u2013171.","journal-title":"Blood Press Monit"},{"key":"e_1_3_1_10_2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/gerona\/glt111","article-title":"Impaired systolic blood pressure recovery directly after standing predicts mortality in older falls clinic patients","volume":"69","author":"Lagro J","year":"2014","unstructured":"Lagro J, Schoon Y, Heerts I, Meel\u2010van den Abeelen AS, Schalk B, Wieling W, Olde Rikkert MG, Claassen JA. Impaired systolic blood pressure recovery directly after standing predicts mortality in older falls clinic patients. J Gerontol A Biol Sci Med Sci. 2014;69:471\u2013478.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"e_1_3_1_11_2","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s10286-015-0315-9","article-title":"Phenotypes of orthostatic blood pressure behaviour and association with visual acuity","volume":"25","author":"Ni Bhuachalla B","year":"2015","unstructured":"Ni Bhuachalla B, McGarrigle CA, Akuffo KO, Peto T, Beatty S, Kenny RA. Phenotypes of orthostatic blood pressure behaviour and association with visual acuity. Clin Auton Res. 2015;25:373\u2013381.","journal-title":"Clin Auton Res"},{"key":"e_1_3_1_12_2","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1093\/gerona\/glt171","article-title":"Orthostatic hypotension is associated with lower cognitive performance in adults aged 50 plus with supine hypertension","volume":"69","author":"Frewen J","year":"2014","unstructured":"Frewen J, Finucane C, Savva GM, Boyle G, Kenny RA. Orthostatic hypotension is associated with lower cognitive performance in adults aged 50 plus with supine hypertension. J Gerontol A Biol Sci Med Sci. 2014;69:878\u2013885.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"e_1_3_1_13_2","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1093\/ije\/dyr116","article-title":"Cohort profile: the Irish Longitudinal Study on Ageing","volume":"40","author":"Kearney PM","year":"2011","unstructured":"Kearney PM, Cronin H, O'Regan C, Kamiya Y, Savva GM, Whelan B, Kenny R. Cohort profile: the Irish Longitudinal Study on Ageing. Int J Epidemiol. 2011;40:877\u2013884.","journal-title":"Int J Epidemiol"},{"issue":"2","key":"e_1_3_1_14_2","first-page":"S265","article-title":"Design and methodology of the Irish Longitudinal Study on Ageing","volume":"61","author":"Whelan BJ","year":"2013","unstructured":"Whelan BJ, Savva GM. Design and methodology of the Irish Longitudinal Study on Ageing. J Am Geriatr Soc. 2013;61(suppl 2):S265\u2013S268.","journal-title":"J Am Geriatr Soc"},{"issue":"2","key":"e_1_3_1_15_2","first-page":"S269","article-title":"Health and aging: development of the Irish Longitudinal Study on Ageing Health Assessment","volume":"61","author":"Cronin H","year":"2013","unstructured":"Cronin H, O'Regan C, Finucane C, Kearney P, Kenny RA. Health and aging: development of the Irish Longitudinal Study on Ageing Health Assessment. J Am Geriatr Soc. 2013;61(suppl 2):S269\u2013S278.","journal-title":"J Am Geriatr Soc"},{"key":"e_1_3_1_16_2","first-page":"793","article-title":"TILDA Signal Processing Framework (SPF) for the analysis of BP responses to standing in epidemiological and clinical studies","author":"Soraghan CJ","year":"2014","unstructured":"Soraghan CJ, Fan CW, Hayakawa T, Cronin H, Foran T, Boyle G, Kenny RA, Finucane C. TILDA Signal Processing Framework (SPF) for the analysis of BP responses to standing in epidemiological and clinical studies. LEEE EMBS Int Conf Biomed Health Inform. 2014; 793\u2013796.","journal-title":"LEEE EMBS Int Conf Biomed Health Inform"},{"key":"e_1_3_1_17_2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1056\/NEJMoa1114248","article-title":"Estimating glomerular filtration rate from serum creatinine and cystatin C","volume":"367","author":"Inker LA","year":"2012","unstructured":"Inker LA, Schmid CH, Tighiouart H, Eckfeldt JH, Feldman HI, Greene T, Kusek JW, Manzi J, Van Lente F, Zhang YL, Coresh J, Levey AS. Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med. 2012;367:20\u201329.","journal-title":"N Engl J Med"},{"key":"e_1_3_1_18_2","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation\u00a0to estimate glomerular filtration rate","volume":"150","author":"Levey AS","year":"2009","unstructured":"Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF III, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, Coresh J. A new equation\u00a0to estimate glomerular filtration rate. Ann Intern Med. 2009;150:604\u2013612.","journal-title":"Ann Intern Med"},{"key":"e_1_3_1_19_2","unstructured":"WHO Collaborating Centre for Drug Statistics Methodology Guidelines for ATC Classification and DDD Assignment 2012. Oslo: 2011."},{"key":"e_1_3_1_20_2","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/sj.ki.5002374","article-title":"Age\u2010 and gender\u2010specific reference values of estimated GFR in Caucasians: the Nijmegen Biomedical Study","volume":"72","author":"Wetzels JF","year":"2007","unstructured":"Wetzels JF, Kiemeney LA, Swinkels DW, Willems HL, den Heijer M. Age\u2010 and gender\u2010specific reference values of estimated GFR in Caucasians: the Nijmegen Biomedical Study. Kidney Int. 2007;72:632\u2013637.","journal-title":"Kidney Int"},{"key":"e_1_3_1_21_2","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/HJH.0b013e3283350e8c","article-title":"Consequences of orthostatic blood pressure variability in middle\u2010aged men (The Malmo Preventive Project)","volume":"28","author":"Fedorowski A","year":"2010","unstructured":"Fedorowski A, Stavenow L, Hedblad B, Berglund G, Nilsson PM, Melander O. Consequences of orthostatic blood pressure variability in middle\u2010aged men (The Malmo Preventive Project). J Hypertens. 2010;28:551\u2013559.","journal-title":"J Hypertens"},{"key":"e_1_3_1_22_2","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1161\/HYPERTENSIONAHA.110.156380","article-title":"Orthostatic hypotension and incident chronic kidney disease: the Atherosclerosis Risk in Communities Study","volume":"56","author":"Franceschini N","year":"2010","unstructured":"Franceschini N, Rose KM, Astor BC, Couper D, Vupputuri S. Orthostatic hypotension and incident chronic kidney disease: the Atherosclerosis Risk in Communities Study. Hypertension. 2010;56:1054\u20131059.","journal-title":"Hypertension"},{"key":"e_1_3_1_23_2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/ki.2010.431","article-title":"Changes in dietary protein intake has no effect on serum cystatin C levels independent of the glomerular filtration rate","volume":"79","author":"Tangri N","year":"2011","unstructured":"Tangri N, Stevens LA, Schmid CH, Zhang YL, Beck GJ, Greene T, Coresh J, Levey AS. Changes in dietary protein intake has no effect on serum cystatin C levels independent of the glomerular filtration rate. Kidney Int. 2011;79:471\u2013477.","journal-title":"Kidney Int"},{"key":"e_1_3_1_24_2","doi-asserted-by":"crossref","first-page":"348","DOI":"10.2215\/CJN.02870707","article-title":"Influence of muscle mass and physical activity on serum and urinary creatinine and serum cystatin C","volume":"3","author":"Baxmann AC","year":"2008","unstructured":"Baxmann AC, Ahmed MS, Marques NC, Menon VB, Pereira AB, Kirsztajn GM, Heilberg IP. Influence of muscle mass and physical activity on serum and urinary creatinine and serum cystatin C. Clin J Am Soc Nephrol. 2008;3:348\u2013354.","journal-title":"Clin J Am Soc Nephrol"},{"key":"e_1_3_1_25_2","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1056\/NEJMoa1214234","article-title":"Cystatin C versus creatinine in determining risk based on kidney function","volume":"369","author":"Shlipak MG","year":"2013","unstructured":"Shlipak MG, Matsushita K, Arnlov J, Inker LA, Katz R, Polkinghorne KR, Rothenbacher D, Sarnak MJ, Astor BC, Coresh J, Levey AS, Gansevoort RT. Cystatin C versus creatinine in determining risk based on kidney function. N Engl J Med. 2013;369:932\u2013943.","journal-title":"N Engl J Med"},{"key":"e_1_3_1_26_2","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.amjhyper.2005.02.002","article-title":"Reduced baroreflex effectiveness index in hypertensive patients with chronic renal failure","volume":"18","author":"Johansson M","year":"2005","unstructured":"Johansson M, Gao SA, Friberg P, Annerstedt M, Bergstrom G, Carlstrom J, Ivarsson T, Jensen G, Ljungman S, Mathillas O, Nielsen FD, Strombom U. Reduced baroreflex effectiveness index in hypertensive patients with chronic renal failure. Am J Hypertens. 2005;18:995\u20131000.","journal-title":"Am J Hypertens"},{"key":"e_1_3_1_27_2","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1097\/HJH.0b013e32811d6a07","article-title":"Arterial stiffness, cardiovagal baroreflex sensitivity and postural blood pressure changes in older adults: the Rotterdam Study","volume":"25","author":"Mattace\u2010Raso FU","year":"2007","unstructured":"Mattace\u2010Raso FU, van den Meiracker AH, Bos WJ, van der Cammen TJ, Westerhof BE, Elias\u2010Smale S, Reneman RS, Hoeks AP, Hofman A, Witteman JC. Arterial stiffness, cardiovagal baroreflex sensitivity and postural blood pressure changes in older adults: the Rotterdam Study. J Hypertens. 2007;25:1421\u20131426.","journal-title":"J Hypertens"},{"key":"e_1_3_1_28_2","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1681\/ASN.2008030318","article-title":"Cystatin C associates with arterial stiffness in older adults","volume":"20","author":"Madero M","year":"2009","unstructured":"Madero M, Wassel CL, Peralta CA, Najjar SS, Sutton\u2010Tyrrell K, Fried L, Canada R, Newman A, Shlipak MG, Sarnak MJ. Cystatin C associates with arterial stiffness in older adults. J Am Soc Nephrol. 2009;20:1086\u20131093.","journal-title":"J Am Soc Nephrol"},{"key":"e_1_3_1_29_2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11906-015-0571-z","article-title":"Cardiovascular autonomic dysfunction in chronic kidney disease: a comprehensive review","volume":"17","author":"Salman IM","year":"2015","unstructured":"Salman IM. Cardiovascular autonomic dysfunction in chronic kidney disease: a comprehensive review. Curr Hypertens Rep. 2015;17:59.","journal-title":"Curr Hypertens Rep"},{"key":"e_1_3_1_30_2","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1053\/j.ackd.2010.05.002","article-title":"The aging kidney: physiological changes","volume":"17","author":"Weinstein JR","year":"2010","unstructured":"Weinstein JR, Anderson S. The aging kidney: physiological changes. Adv Chronic Kidney Dis. 2010;17:302\u2013307.","journal-title":"Adv Chronic Kidney Dis"},{"key":"e_1_3_1_31_2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.7326\/0003-4819-152-9-201005040-00006","article-title":"The association between age and nephrosclerosis on renal biopsy among healthy adults","volume":"152","author":"Rule AD","year":"2010","unstructured":"Rule AD, Amer H, Cornell LD, Taler SJ, Cosio FG, Kremers WK, Textor SC, Stegall MD. The association between age and nephrosclerosis on renal biopsy among healthy adults. Ann Intern Med. 2010;152:561\u2013567.","journal-title":"Ann Intern Med"},{"issue":"1","key":"e_1_3_1_32_2","doi-asserted-by":"crossref","first-page":"p6","DOI":"10.1159\/000328012","article-title":"Senile nephrosclerosis\u2014does it explain the decline in glomerular filtration rate with aging?","volume":"119","author":"Rule AD","year":"2011","unstructured":"Rule AD, Cornell LD, Poggio ED. Senile nephrosclerosis\u2014does it explain the decline in glomerular filtration rate with aging? Nephron Physiol. 2011;119(suppl 1):p6\u2013p11.","journal-title":"Nephron Physiol"},{"key":"e_1_3_1_33_2","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/ki.2012.65","article-title":"The implications of anatomical and functional changes of the aging kidney: with an emphasis on the glomeruli","volume":"82","author":"Glassock RJ","year":"2012","unstructured":"Glassock RJ, Rule AD. The implications of anatomical and functional changes of the aging kidney: with an emphasis on the glomeruli. Kidney Int. 2012;82:270\u2013277.","journal-title":"Kidney Int"},{"key":"e_1_3_1_34_2","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0008-6363(98)00067-4","article-title":"Fifteen years experience with finger arterial pressure monitoring: assessment of the technology","volume":"38","author":"Imholz BPM","year":"1998","unstructured":"Imholz BPM, Wieling W, van Montfrans GA, Wesseling KH. Fifteen years experience with finger arterial pressure monitoring: assessment of the technology. Cardiovasc Res. 1998;38:605\u2013616.","journal-title":"Cardiovasc Res"},{"key":"e_1_3_1_35_2","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/cvr\/24.3.214","article-title":"Noninvasive continuous finger blood\u2010pressure measurement during orthostatic stress compared to intraarterial pressure","volume":"24","author":"Imholz BPM","year":"1990","unstructured":"Imholz BPM, Settels JJ, Vandermeiracker AH, Wesseling KH, Wieling W. Noninvasive continuous finger blood\u2010pressure measurement during orthostatic stress compared to intraarterial pressure. Cardiovasc Res. 1990;24:214\u2013221.","journal-title":"Cardiovasc Res"},{"key":"e_1_3_1_36_2","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.2215\/CJN.11111015","article-title":"Association of reduced eGFR and albuminuria with serious fall injuries among older adults","volume":"11","author":"Bowling CB","year":"2016","unstructured":"Bowling CB, Bromfield SG, Colantonio LD, Gutierrez OM, Shimbo D, Reynolds K, Wright NC, Curtis JR, Judd SE, Franch H, Warnock DG, McClellan W, Muntner P. Association of reduced eGFR and albuminuria with serious fall injuries among older adults. Clin J Am Soc Nephrol. 2016;11:1236\u20131243.","journal-title":"Clin J Am Soc Nephrol"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.117.005661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T23:36:38Z","timestamp":1760484998000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.117.005661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1161\/JAHA.117.005661"],"URL":"https:\/\/doi.org\/10.1161\/jaha.117.005661","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"2017-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e005661"}}