{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:10:53Z","timestamp":1789819853276,"version":"4.0.1"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The relative benefit of higher statin dosing in patients with peripheral artery disease has not been reported previously. We compared the effectiveness of low\u2010 or moderate\u2010intensity (\n              <jats:styled-content style=\"fixed-case\">LMI<\/jats:styled-content>\n              ) versus high\u2010intensity (\n              <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content>\n              ) statin dose on clinical outcomes in patients with peripheral artery disease.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We reviewed patients with symptomatic peripheral artery disease who underwent peripheral angiography and\/or endovascular intervention from 2006 to 2013 who were not taking other lipid\u2010lowering medications. HI statin use was defined as atorvastatin 40\u201380\u00a0mg or rosuvastatin 20\u201340\u00a0mg. Baseline demographics, procedural data, and outcomes were retrospectively analyzed. Among 909 patients, 629 (69%) were prescribed statins, and 124 (13.6%) were treated with\n              <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content>\n              statin therapy. Mean low\u2010density lipoprotein level was similar in patients on\n              <jats:styled-content style=\"fixed-case\">LMI<\/jats:styled-content>\n              versus\n              <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content>\n              (80\u00b130 versus 87\u00b144\u00a0mg\/dL,\n              <jats:italic>P<\/jats:italic>\n              =0.14). Demographics including age (68\u00b112 versus 67\u00b110\u00a0years,\n              <jats:italic>P<\/jats:italic>\n              =0.25), smoking history (76% versus 80%,\n              <jats:italic>P<\/jats:italic>\n              =0.42), diabetes mellitus (54% versus 48%,\n              <jats:italic>P<\/jats:italic>\n              =0.17), and hypertension (88% versus 89%,\n              <jats:italic>P<\/jats:italic>\n              =0.78) were similar between groups (\n              <jats:styled-content style=\"fixed-case\">LMI<\/jats:styled-content>\n              versus\n              <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content>\n              ). There was a higher prevalence of coronary artery disease (56% versus 75%,\n              <jats:italic>P<\/jats:italic>\n              =0.0001) among patients on\n              <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content>\n              statin (versus\n              <jats:styled-content style=\"fixed-case\">LMI<\/jats:styled-content>\n              ). After propensity weighting,\n              <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content>\n              statin therapy was associated with improved survival (hazard ratio for mortality: 0.52; 95% confidence interval, 0.33\u20130.81;\n              <jats:italic>P<\/jats:italic>\n              =0.004) and decreased major adverse cardiovascular events (hazard ratio: 0.58; 95% confidence interval 0.37\u20130.92,\n              <jats:italic>P<\/jats:italic>\n              =0.02).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In patients with peripheral artery disease who were referred for peripheral angiography or endovascular intervention,\n              <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content>\n              statin therapy was associated with improved survival and fewer major adverse cardiovascular events compared with\n              <jats:styled-content style=\"fixed-case\">LMI<\/jats:styled-content>\n              statin therapy.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.005699","type":"journal-article","created":{"date-parts":[[2017,7,16]],"date-time":"2017-07-16T00:10:20Z","timestamp":1500163820000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":59,"title":["High\u2010Intensity Statin Therapy Is Associated With Improved Survival in Patients With Peripheral Artery Disease"],"prefix":"10.1161","volume":"6","author":[{"given":"T.","family":"Raymond Foley","sequence":"first","affiliation":[{"name":"Section of Cardiology Denver VA Medical Center and University of Colorado School of Medicine Aurora CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gagan D.","family":"Singh","sequence":"additional","affiliation":[{"name":"Section of Cardiology University of California\u2013Davis Sacramento CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damianos G.","family":"Kokkinidis","sequence":"additional","affiliation":[{"name":"Section of Cardiology Denver VA Medical Center and University of Colorado School of Medicine Aurora CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho\u2010Hin K.","family":"Choy","sequence":"additional","affiliation":[{"name":"Section of Cardiology University of California\u2013Davis Sacramento CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai H.","family":"Pham","sequence":"additional","affiliation":[{"name":"Section of Cardiology University of California\u2013Davis Sacramento CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezra A.","family":"Amsterdam","sequence":"additional","affiliation":[{"name":"Section of Cardiology University of California\u2013Davis Sacramento CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John 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