{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T18:10:24Z","timestamp":1769105424413,"version":"3.49.0"},"reference-count":55,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,7]]},"abstract":"\n Background<\/jats:title>\n \n The aim of our study was to evaluate the relationship of pulse pressure (\n PP<\/jats:styled-content>\n ), a raw index of arterial stiffness, with noninvasively determined coronary flow reserve (\n CFR<\/jats:styled-content>\n ) and its components, in patients with angiographically normal epicardial coronary arteries.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n The study population included 398 patients without angiographic evidence of coronary stenosis, who underwent high\u2010dose dipyridamole stress echocardiography with transthoracic\u2010derived\n CFR<\/jats:styled-content>\n evaluation on the left anterior descending artery.\n CFR<\/jats:styled-content>\n was calculated as the ratio between high\u2010dose dipyridamole and resting coronary diastolic peak velocities. Patients were divided into 2 groups: the first group included the first and second\n PP<\/jats:styled-content>\n tertiles (n=298,\n PP<\/jats:styled-content>\n \u226460\u00a0mm\u00a0Hg) and the second group included the highest\n PP<\/jats:styled-content>\n tertile (n=100,\n PP<\/jats:styled-content>\n >60\u00a0mm\u00a0Hg). Mean blood pressure, systolic blood pressure (both\n P<\/jats:italic>\n <0.0001), age (\n P<\/jats:italic>\n <0.002), and left ventricular mass index (\n P<\/jats:italic>\n =0.013) were higher in the highest\n PP<\/jats:styled-content>\n tertile, which also showed higher resting coronary flow velocity (31.6\u00b19.6\u00a0cm\/s versus 27.7\u00b16.4\u00a0cm\/s,\n P<\/jats:italic>\n <0.0001) and marginally lower\n CFR<\/jats:styled-content>\n (2.5\u00b10.6 versus 2.6\u00b10.6,\n P<\/jats:italic>\n =0.044). Hyperemic coronary flow velocity did not differ between the 2 groups. By separate multiple linear regression analyses, after adjusting for sex, age, the highest systolic blood pressure tertile (\u2265140\u00a0mm\u00a0Hg), left ventricular mass index, and cardiovascular risk factors, the highest\n PP<\/jats:styled-content>\n tertile was associated with resting coronary flow velocity (\n P<\/jats:italic>\n =0.003) and only marginally with hyperemic coronary flow velocity (\n P<\/jats:italic>\n <0.02), whereas its association with\n CFR<\/jats:styled-content>\n was not significant.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In patients without epicardial coronary artery stenosis, the highest\n PP<\/jats:styled-content>\n tertile is associated with an increased coronary flow velocity at rest.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.005710","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T00:30:33Z","timestamp":1498782633000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Association Between Elevated Pulse Pressure and High Resting Coronary Blood Flow Velocity in Patients With Angiographically Normal Epicardial Coronary Arteries"],"prefix":"10.1161","volume":"6","author":[{"given":"Maria","family":"Lembo","sequence":"first","affiliation":[{"name":"Department of Advanced Biomedical Sciences, Federico II University Hospital, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Sicari","sequence":"additional","affiliation":[{"name":"Institute of Clinical Physiology, National Research Council, Pisa, 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