{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:23:09Z","timestamp":1793125389997,"version":"4.5.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,11,6]]},"abstract":"\n Background<\/jats:title>\n \n Acute kidney injury (\n AKI<\/jats:styled-content>\n ) following primary percutaneous coronary intervention (\n pPCI<\/jats:styled-content>\n ) is frequently interpreted as contrast\u2010induced\n AKI<\/jats:styled-content>\n but may result from other insults. We aimed to determine the causal association of contrast material exposure and the incidence of AKI following p\n PCI<\/jats:styled-content>\n using a control group of propensity score\u2013matched patients with ST\u2010segment\u2013elevation myocardial infarction who were not exposed to contrast material.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We studied 2025 patients with ST\u2010segment\u2013elevation myocardial infarction who underwent\n pPCI<\/jats:styled-content>\n and 1025 patients receiving fibrinolysis or no reperfusion who were not exposed to contrast material during the first 72\u00a0hours of hospital stay (control group).\n AKI<\/jats:styled-content>\n was defined as creatinine of \u22650.5\u00a0mg\/dL or >25% rise within 72\u00a0hours.\n AKI<\/jats:styled-content>\n rates were similar in the\n pPCI<\/jats:styled-content>\n and control groups (10.3% versus 12.1%, respectively;\n P<\/jats:italic>\n =0.38). Propensity score matching resulted in 931 matched pairs with\n PCI<\/jats:styled-content>\n and no\n PCI,<\/jats:styled-content>\n with balanced baseline covariates (standardized difference <0.1). Among propensity score\u2013matched patients,\n AKI<\/jats:styled-content>\n rates were not significantly different with and without\n PCI<\/jats:styled-content>\n (8.6% versus 10.9%,\n P<\/jats:italic>\n =0.12). In the\n pPCI<\/jats:styled-content>\n cohort, independent predictors of\n AKI<\/jats:styled-content>\n included age \u226570 years, insulin\u2010treated diabetes mellitus, diuretic therapy, anterior infarction, baseline estimated glomerular filtration rate, and variables related to the presence of pump failure (higher Killip class, intra\u2010aortic balloon pump use) and reduced left ventricular ejection fraction but not contrast material dose. A risk score based on the\n PCI<\/jats:styled-content>\n cohort had similar discriminatory capacity for\n AKI<\/jats:styled-content>\n in the control group (C statistic 0.81\u00b10.02 and 0.78\u00b10.02, respectively;\n P<\/jats:italic>\n =0.26).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The development of\n AKI<\/jats:styled-content>\n in patients with ST\u2010segment\u2013elevation myocardial infarction undergoing\n pPCI<\/jats:styled-content>\n is mainly related to older age, baseline estimated glomerular filtration rate, heart failure, and hemodynamic instability. Risk for\n AKI<\/jats:styled-content>\n is similar among ST\u2010segment\u2013elevation myocardial infarction patients with and without contrast material exposure.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.005715","type":"journal-article","created":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T20:10:16Z","timestamp":1498335016000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":82,"title":["Acute Kidney Injury After Primary Angioplasty: Is Contrast\u2010Induced Nephropathy the Culprit?"],"prefix":"10.1161","volume":"6","author":[{"given":"Oren","family":"Caspi","sequence":"first","affiliation":[{"name":"Department of Cardiology, Rambam Medical Center, Haifa, Israel"},{"name":"B. Rappaport Faculty of Medicine, Technion Medical School, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manhal","family":"Habib","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rambam Medical Center, Haifa, Israel"},{"name":"B. Rappaport Faculty of Medicine, Technion Medical School, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuval","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rambam Medical Center, Haifa, Israel"},{"name":"B. Rappaport Faculty of Medicine, Technion Medical School, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Kerner","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rambam Medical Center, Haifa, Israel"},{"name":"B. Rappaport Faculty of Medicine, Technion Medical School, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Roguin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rambam Medical Center, Haifa, Israel"},{"name":"B. Rappaport Faculty of Medicine, Technion Medical School, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eitan","family":"Abergel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rambam Medical Center, Haifa, Israel"},{"name":"B. Rappaport Faculty of Medicine, Technion Medical School, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monther","family":"Boulos","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rambam Medical Center, Haifa, Israel"},{"name":"B. Rappaport Faculty of Medicine, Technion Medical School, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Kapeliovich","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rambam Medical Center, Haifa, Israel"},{"name":"B. Rappaport Faculty of Medicine, Technion Medical School, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Beyar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rambam Medical Center, Haifa, Israel"},{"name":"B. Rappaport Faculty of Medicine, Technion Medical School, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Nikolsky","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rambam Medical Center, Haifa, Israel"},{"name":"B. Rappaport Faculty of Medicine, Technion Medical School, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doron","family":"Aronson","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rambam Medical Center, Haifa, Israel"},{"name":"B. 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