{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:39:19Z","timestamp":1792679959624,"version":"4.5.0"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Autologous adipose tissue\u2013derived mesenchymal stem cells (\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">ATMSC<\/jats:styled-content>\n              s) therapy is a promising strategy to improve post\u2013myocardial infarction outcomes. In a porcine model of acute myocardial infarction, we studied the long\u2010term effects and the mechanisms involved in allogeneic\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">ATMSC<\/jats:styled-content>\n              s administration on myocardial performance.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Thirty\u2010eight pigs underwent 50\u00a0minutes of coronary occlusion; the study was completed in 33 pigs. After reperfusion, allogeneic\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">ATMSC<\/jats:styled-content>\n              s or culture medium (vehicle) were intracoronarily administered. Follow\u2010ups were performed at short (2\u00a0days after acute myocardial infarction vehicle\u2010treated, n=10;\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">ATMSC<\/jats:styled-content>\n              s\u2010treated, n=9) or long term (60\u00a0days after acute myocardial infarction vehicle\u2010treated, n=7;\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">ATMSC<\/jats:styled-content>\n              s\u2010treated, n=7). At short term, infarcted myocardium analysis showed reduced apoptosis in the\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">ATMSC<\/jats:styled-content>\n              s\u2010treated animals (48.6\u00b16% versus 55.9\u00b15.7% in vehicle;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.017); enhancement of the reparative process with up\u2010regulated vascular endothelial growth factor, granulocyte macrophage colony\u2010stimulating factor, and stromal\u2010derived factor\u20101\u03b1 gene expression; and increased M2 macrophages (67.2\u00b110% versus 54.7\u00b110.2% in vehicle;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.016). In long\u2010term groups, increase in myocardial perfusion at the anterior infarct border was observed both on day\u20107 and day\u201060 cardiac magnetic resonance studies in\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">ATMSC<\/jats:styled-content>\n              s\u2010treated animals, compared to vehicle\u00a0(87.9\u00b128.7 versus 57.4\u00b117.7\u00a0mL\/min per gram at 7\u00a0days;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.034 and 99\u00b122.6 versus 43.3\u00b114.7 22.6\u00a0mL\/min per gram\u00a0at 60\u00a0days;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.0001, respectively). At day 60, higher vascular density was detected at the border zone in\u00a0the\u00a0\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">ATMSC<\/jats:styled-content>\n              s\u2010treated animals (118\u00b118 versus 92.4\u00b124.3\u00a0vessels\/mm\n              <jats:sup>2<\/jats:sup>\n              in vehicle;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.045). Cardiac magnetic resonance\u2013measured left ventricular ejection fraction of left ventricular volumes was not different between groups at any time point.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In this porcine acute myocardial infarction model, allogeneic\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">ATMSC<\/jats:styled-content>\n              s\u2010based therapy was associated with increased cardioprotective and reparative mechanisms and with better cardiac magnetic resonance\u2013measured perfusion. No effect on left ventricular volumes or ejection fraction was observed.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.005771","type":"journal-article","created":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T20:10:32Z","timestamp":1493842232000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":48,"title":["Intracoronary Administration of Allogeneic Adipose Tissue\u2013Derived Mesenchymal Stem Cells Improves Myocardial Perfusion But Not Left Ventricle Function, in a Translational Model of Acute Myocardial Infarction"],"prefix":"10.1161","volume":"6","author":[{"given":"Joaquim","family":"Bobi","sequence":"first","affiliation":[{"name":"Universitat de Barcelona","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Solanes","sequence":"additional","affiliation":[{"name":"Universitat de Barcelona","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Fern\u00e1ndez\u2010Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares Carlos III, CNIC","place":["Madrid, Spain"]},{"name":"Icahn School of Medicine at Mount Sinai","place":["New York"]},{"name":"CIBER de enfermedades CardioVasculares (CIBERCV)","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Gal\u00e1n\u2010Arriola","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares Carlos III, CNIC","place":["Madrid, Spain"]},{"name":"CIBER de enfermedades CardioVasculares (CIBERCV)","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Dantas","sequence":"additional","affiliation":[{"name":"Universitat de Barcelona","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Fern\u00e1ndez\u2010Friera","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares Carlos III, CNIC","place":["Madrid, Spain"]},{"name":"Hospital Universitario HM Montepr\u00edncipe","place":["Madrid, Spain"]},{"name":"CIBER de enfermedades CardioVasculares (CIBERCV)","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"G\u00e1lvez\u2010Mont\u00f3n","sequence":"additional","affiliation":[{"name":"Health Science Research Institute Germans Trias i Pujol","place":["Badalona, Spain"]},{"name":"CIBER de enfermedades CardioVasculares (CIBERCV)","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"Rigol\u2010Monz\u00f3","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic de Barcelona","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Ag\u00fcero","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares Carlos III, CNIC","place":["Madrid, Spain"]},{"name":"CIBER de enfermedades CardioVasculares (CIBERCV)","place":["Madrid, Spain"]},{"name":"Hospital Universitari i Politecnic La Fe","place":["Valencia, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic de Barcelona","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merc\u00e8","family":"Roqu\u00e9","sequence":"additional","affiliation":[{"name":"Universitat de Barcelona","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Bay\u00e9s\u2010Gen\u00eds","sequence":"additional","affiliation":[{"name":"Health Science Research Institute Germans Trias i Pujol","place":["Badalona, Spain"]},{"name":"Germans Trias i Pujol University Hospital","place":["Badalona, Spain"]},{"name":"Universitat Aut\u00f2noma de Barcelona (UAB)","place":["Barcelona, Spain"]},{"name":"CIBER de enfermedades CardioVasculares (CIBERCV)","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"S\u00e1nchez\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Philips Healthcare","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Garc\u00eda\u2010\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Universitat de Barcelona","place":["Spain"]},{"name":"Centro Nacional de Investigaciones Cardiovasculares Carlos III, CNIC","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manel","family":"Sabat\u00e9","sequence":"additional","affiliation":[{"name":"Universitat de Barcelona","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Roura","sequence":"additional","affiliation":[{"name":"Health Science Research Institute Germans Trias i Pujol","place":["Badalona, Spain"]},{"name":"Center of Regenerative Medicine in Barcelona","place":["Barcelona, Spain"]},{"name":"CIBER de enfermedades CardioVasculares (CIBERCV)","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borja","family":"Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares Carlos III, CNIC","place":["Madrid, Spain"]},{"name":"IIS\u2010 Fundaci\u00f3n Jim\u00e9nez D\u00edaz Hospital","place":["Madrid, Spain"]},{"name":"CIBER de enfermedades CardioVasculares (CIBERCV)","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Rigol","sequence":"additional","affiliation":[{"name":"Universitat 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