{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T14:42:57Z","timestamp":1777300977688,"version":"3.51.4"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,10,11]]},"abstract":"\n Background<\/jats:title>\n There are few data describing the longitudinal use of and adherence to heart failure medications following left ventricular assist device (LVAD) implantation.<\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Using a large US commercial insurance database, patients who received an\n LVAD<\/jats:styled-content>\n (\n International Classification of Diseases, 9th Revision, Clinical Modification<\/jats:italic>\n code 37.66) and survived to hospital discharge without heart transplantation between January 1, 2006, and March 31, 2015, were identified. Heart failure medication use from 3\u00a0months before 1\u2010year post\u2010\n LVAD<\/jats:styled-content>\n was examined using linked pharmacy claims. Differences in the proportion of patients taking heart failure medications post\n LVAD<\/jats:styled-content>\n compared with pre\n LVAD<\/jats:styled-content>\n were examined using McNemar test. Predictors of post\u2010\n LVAD<\/jats:styled-content>\n medication use and poor medication adherence (proportion of days covered <0.8) were identified via logistic regression. Among 362 patients (mean age, 57.4\u00a0years; 75.1% men), compared with pre\n LVAD<\/jats:styled-content>\n , the proportion of patients taking anticoagulants and antiarrhythmics following\n LVAD<\/jats:styled-content>\n increased; mineralocorticoid receptor antagonists, thiazide diuretics, and digoxin decreased; and \u03b2\u2010blockers, angiotensin\u2010converting enzyme inhibitors\/angiotensin receptor blockers, and loop diuretics did not change. Pre\u2010\n LVAD<\/jats:styled-content>\n medication use was associated with post\u2010\n LVAD<\/jats:styled-content>\n use across all medication classes. The proportion of patients with poor medication adherence was 28.8%, 39.0%, and 36.0% for \u03b2\u2010blockers, angiotensin\u2010converting enzyme inhibitors\/angiotensin receptor blockers, and anticoagulants, respectively. Many patients with poor adherence completely discontinued use of the medication.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Neurohormonal antagonist use after\n LVAD<\/jats:styled-content>\n was inconsistent, perhaps reflecting uncertainty of therapeutic benefit in this population. Medication adherence post\u2010\n LVAD<\/jats:styled-content>\n was poor in many patients. Further work is needed to delineate the reasons for nonadherence after\n LVAD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.005776","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T00:11:20Z","timestamp":1507075880000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Longitudinal Heart Failure Medication Use and Adherence Following Left Ventricular Assist Device Implantation in Privately Insured Patients"],"prefix":"10.1161","volume":"6","author":[{"given":"Nicholas Y.","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Mayo Clinic, Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsey R.","family":"Sangaralingham","sequence":"additional","affiliation":[{"name":"Division of Health Care Policy and Research, Department of Health Sciences Research, Mayo Clinic, Rochester, MN"},{"name":"Mayo Clinic Robert D. and Patricia E. 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