{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T16:19:21Z","timestamp":1756570761863,"version":"3.41.2"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The ankle\u2010brachial index (ABI) is inadequate to detect early\u2010stage atherosclerotic disease, when interventions to prevent functional decline may be the most effective. We determined associations of femoral artery atherosclerosis with physical functioning, across the spectrum of the ABI, and within the normal ABI range.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In 2007\u20132011, 1103 multiethnic men and women participated in the San Diego Population Study, and completed all components of the summary performance score. Using Doppler ultrasound, superficial and common femoral intima media thickness and plaques were ascertained. Logistic regression was used to assess associations of femoral atherosclerosis with the summary performance score and its individual components. Models were adjusted for demographics, lifestyle factors, comorbidities, lipids, and kidney function. In adjusted models, among participants with a normal\u2010range ABI (1.00\u20131.30), the highest tertile of superficial intima media thickness was associated with lower odds of a perfect summary performance score of 12 (odds ratio=0.56 [0.36, 0.87],\n              <jats:italic>P<\/jats:italic>\n              =0.009), and lower odds of a 4\u2010m walk score of 4 (0.34 [0.16, 0.73],\n              <jats:italic>P<\/jats:italic>\n              =0.006) and chair rise score of 4 (0.56 [0.34, 0.94],\n              <jats:italic>P<\/jats:italic>\n              =0.03). Plaque presence (0.53 [0.29, 0.99],\n              <jats:italic>P<\/jats:italic>\n              =0.04) and greater total plaque burden (0.61 [0.43, 0.87],\n              <jats:italic>P<\/jats:italic>\n              =0.006) were associated with worse 4\u2010m walk performance in the normal\u2010range ABI group. Higher superficial intima media thickness was associated with lower summary performance score in all individuals (\n              <jats:italic>P<\/jats:italic>\n              =0.02).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Findings suggest that use of femoral artery atherosclerosis measures may be effective in individuals with a normal\u2010range ABI, especially, for example, those with diabetes mellitus or a family history of peripheral artery disease, when detection can lead to earlier intervention to prevent functional declines and improve quality of life.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.005777","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T00:10:36Z","timestamp":1500595836000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Femoral Artery Atherosclerosis Is Associated With Physical Function Across the Spectrum of the Ankle\u2010Brachial Index: The San Diego Population Study"],"prefix":"10.1161","volume":"6","author":[{"given":"Christina L.","family":"Wassel","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, College of Medicine, University of Vermont, Burlington, VT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia M.","family":"Ellis","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, College of Medicine, University of Vermont, Burlington, VT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie C.","family":"Suder","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Barinas\u2010Mitchell","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dena E.","family":"Rifkin","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine, Department of Family Medicine and Public Health, School of Medicine, University of California\u2010San Diego, La Jolla, CA"},{"name":"Division of Nephrology, Department of Medicine, School of Medicine, University of California\u2010San Diego, La Jolla, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nketi I.","family":"Forbang","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine, Department of Family Medicine and Public Health, School of Medicine, University of California\u2010San Diego, La Jolla, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie O.","family":"Denenberg","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine, Department of Family Medicine and Public Health, School of Medicine, University of California\u2010San Diego, La Jolla, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoinette M.","family":"Marasco","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belinda J.","family":"McQuaide","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy S.","family":"Jenny","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, College of Medicine, University of Vermont, Burlington, VT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew A.","family":"Allison","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine, Department of Family Medicine and Public Health, School of Medicine, University of California\u2010San Diego, La Jolla, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim H.","family":"Ix","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine, Department of Family Medicine and Public Health, School of Medicine, University of California\u2010San Diego, La Jolla, CA"},{"name":"Division of Nephrology, Department of Medicine, School of Medicine, University of California\u2010San Diego, La Jolla, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael H.","family":"Criqui","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine, Department of Family Medicine and Public Health, School of Medicine, University of California\u2010San Diego, La Jolla, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61249-0"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2006.12.010"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.109.930735"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.11.1317"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.13.1599"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.09.063"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/1741826711420346"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.11.023"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000257"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2016.02.066"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2009.03.008"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2011.04.009"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.10.024"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(02)00071-0"},{"key":"e_1_3_4_16_2","first-page":"45","article-title":"Femoral artery wall morphology, hemostatic factors and intermittent claudication: ultrasound study in men at high and low risk for atherosclerotic disease","volume":"26","author":"Agewall S","year":"1996","unstructured":"Agewall S, Wikstrand J, Wendelhag I, Tengborn L, Fagerberg B. Femoral artery wall morphology, hemostatic factors and intermittent claudication: ultrasound study in men at high and low risk for atherosclerotic disease. Haemostasis. 1996;26:45\u201357.","journal-title":"Haemostasis"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00547-3"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000226198.44181.0c"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.34884"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg166"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2007.03.052"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.546507"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.04.044"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.10.016"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1159\/000097034"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/55.4.M221"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/20.4.470"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/18.6.499"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-3797(03)00092-8"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1114248"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1037\/a0020761"},{"key":"e_1_3_4_32_2","first-page":"1","article-title":"Arteriosclerosis and arterial thrombosis in the lower limb; a roentgenological study","volume":"80","author":"Lindbom A","year":"1950","unstructured":"Lindbom A. Arteriosclerosis and arterial thrombosis in the lower limb; a roentgenological study. Acta Radiol Suppl. 1950;80:1\u201380.","journal-title":"Acta Radiol Suppl"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.11.3026"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2007.11.023"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1177\/0003319716651777"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.06.023"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.117.005777","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:30:29Z","timestamp":1715596229000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.117.005777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1161\/JAHA.117.005777"],"URL":"https:\/\/doi.org\/10.1161\/jaha.117.005777","relation":{},"ISSN":["2047-9980"],"issn-type":[{"type":"electronic","value":"2047-9980"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"2017-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e005777"}}