{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:02:33Z","timestamp":1793088153396,"version":"4.5.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">There is controversy surrounding the risk of ischemic stroke associated with the use of calcium supplements either in monotherapy or in combination with vitamin D.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">A nested case\u2010control study was performed with patients aged 40 to 89\u00a0years old, among whom a total of 2690 patients had a first episode of nonfatal ischemic stroke and for which 19\u00a0538 controls were randomly selected from the source population and frequency\u2010matched with cases for age, sex, and calendar year. Logistic regression provided the odds ratios while adjusting for confounding factors. A sensitivity analysis was performed by restricting to patients who were new users of calcium supplements as either monotherapy or with vitamin D. Calcium supplementation with vitamin D was not associated with an increased risk of ischemic stroke (odds ratio 0.85; 95% confidence interval, 0.67\u20131.08) in the population as a whole or under any of the conditions examined (dose, duration, background cardiovascular risk, sex, or age). Calcium supplement monotherapy was not associated with an increased risk in the population as a whole (odds ratio 1.18; 95% confidence interval, 0.86\u20131.61), although a significant increased risk at high doses (\u22651000\u00a0mg\/day: odds ratio 2.09; 95% confidence interval, 1.25\u20133.49; &lt;1000\u00a0mg: odds ratio 0.76; 95% confidence interval, 0.45\u20131.26) compared with nonuse was observed. The sensitivity analysis did not affect the inferences, with similar results observed among new users as to the overall study population.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">This study suggests that calcium supplements given as monotherapy at high doses may increase the risk of ischemic stroke, whereas their combination with vitamin D seems to offset this hazard.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.005795","type":"journal-article","created":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T20:10:26Z","timestamp":1495138226000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["Risk of Ischemic Stroke Associated With Calcium Supplements With or Without Vitamin D: A Nested Case\u2010Control Study"],"prefix":"10.1161","volume":"6","author":[{"given":"Francisco J.","family":"de Abajo","sequence":"first","affiliation":[{"name":"University Hospital Pr\u00edncipe de Asturias","place":["Alcal\u00e1 de Henares, Spain"]},{"name":"University of Alcal\u00e1","place":["Alcal\u00e1 de Henares, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Rodr\u00edguez\u2010Mart\u00edn","sequence":"additional","affiliation":[{"name":"University Hospital Pr\u00edncipe de Asturias","place":["Alcal\u00e1 de Henares, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Rodr\u00edguez\u2010Miguel","sequence":"additional","affiliation":[{"name":"University Hospital Pr\u00edncipe de Asturias","place":["Alcal\u00e1 de Henares, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel J.","family":"Gil","sequence":"additional","affiliation":[{"name":"Spanish Agency for Medicines and Medical Devices","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1007\/s00198-014-2794-2","article-title":"Clinician's Guide to Prevention and Treatment of Osteoporosis","volume":"25","author":"Cosman F","year":"2014","unstructured":"Cosman F, de Beur SJ, LeBoff MS, Leweicki EM, Tanner B, Randall S, Linday R. 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