{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:34:04Z","timestamp":1792611244249,"version":"4.5.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,7]]},"abstract":"\n Background<\/jats:title>\n \n Reversibility of left ventricular (\n LV<\/jats:styled-content>\n ) dysfunction in high\u2010risk aortic stenosis patient and its impact on survival after transcatheter aortic valve replacement (\n TAVR<\/jats:styled-content>\n ) are unclear. We aimed to evaluate longitudinal changes of\n LV<\/jats:styled-content>\n structure and function after\n TAVR<\/jats:styled-content>\n and their impact on survival.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We studied 209 patients with aortic stenosis who underwent\n TAVR<\/jats:styled-content>\n from May 2006 to December 2012. Echocardiograms were used to calculate\n LV<\/jats:styled-content>\n end\u2010diastolic volume index (LV\n EDV<\/jats:styled-content>\n i),\n LV<\/jats:styled-content>\n ejection fraction,\n LV<\/jats:styled-content>\n mass index (\n LVM<\/jats:styled-content>\n i), and global longitudinal strain before, immediately (<10\u00a0days), late (1\u20133\u00a0months), and yearly after\n TAVR<\/jats:styled-content>\n . During a median follow\u2010up of 1345\u00a0days, 118 patients died, with 26 dying within 1\u00a0year. Global longitudinal strain,\n LVEDV<\/jats:styled-content>\n i,\n LV<\/jats:styled-content>\n ejection fraction, and\n LVM<\/jats:styled-content>\n i improved during follow\u2010up. In patients who died during the first year, death was preceded by\n LVEDV<\/jats:styled-content>\n i and\n LVM<\/jats:styled-content>\n i increase. Multivariable longitudinal data analysis showed that aortic regurgitation at baseline, aortic regurgitation at 30\u00a0days, and initial\n LVEDV<\/jats:styled-content>\n i were independent predictors of subsequent\n LVEDV<\/jats:styled-content>\n i. In a joint analysis of longitudinal and survival data, baseline Society of Thoracic Surgeons score was predictive of\u00a0survival, with no additive effect of longitudinal changes in\n LVEDV<\/jats:styled-content>\n i,\n LVM<\/jats:styled-content>\n i, global longitudinal strain, or\n LV<\/jats:styled-content>\n ejection fraction. Presence of aortic regurgitation at 1\u00a0month after\n TAVR<\/jats:styled-content>\n was the only predictor of 1\u2010year survival.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n LV<\/jats:styled-content>\n reverse remodeling was observed after\n TAVR<\/jats:styled-content>\n , whereas lack of\n LVEDV<\/jats:styled-content>\n i and\n LVM<\/jats:styled-content>\n i improvement was observed in patients who died during the first year after\n TAVR<\/jats:styled-content>\n . Post\u2010\n TAVR<\/jats:styled-content>\n , aortic regurgitation blocks reverse remodeling and is associated with poor 1\u2010year survival after\n TAVR<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.005798","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T00:40:23Z","timestamp":1499820023000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":75,"title":["Reversibility of Cardiac Function Predicts Outcome After Transcatheter Aortic Valve Replacement in Patients With Severe Aortic Stenosis"],"prefix":"10.1161","volume":"6","author":[{"given":"Kimi","family":"Sato","sequence":"first","affiliation":[{"name":"Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnav","family":"Kumar","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon M.","family":"Jones","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie L.","family":"Mick","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amar","family":"Krishnaswamy","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Grimm","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milind Y.","family":"Desai","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian P.","family":"Griffin","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Leonardo","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir R.","family":"Kapadia","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy A.","family":"Obuchowski","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoran B.","family":"Popovi\u0107","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra072139"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.516963"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00786-5"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1514616"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008232"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.01.022"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/9781119513469"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v071.i03"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.79.4.744"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.04.021"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002866"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.12.006"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.02.087"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.009"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.07.001"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.114.002041"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.1132"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.78.1.68"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00025.2002"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.113.000722"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(85)80418-6"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.58.2.255"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2009.07.008"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-012-0308-8"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.04.023"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-303927"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2016.05.023"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu384"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2015.06.011"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f55"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.10.067"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.117.005798","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:32:07Z","timestamp":1715596327000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.117.005798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1161\/JAHA.117.005798"],"URL":"https:\/\/doi.org\/10.1161\/jaha.117.005798","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"2017-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e005798"}}