{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:25:00Z","timestamp":1790958300771,"version":"4.1.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,8,2]]},"abstract":"\n Background<\/jats:title>\n \n Carotid atherosclerotic plaque rupture is an important source of ischemic stroke. However, the prevalence of high\u2010risk plaque (\n HRP<\/jats:styled-content>\n ) defined as plaques with luminal surface disruption, a lipid\u2010rich necrotic core occupying >40% of the wall, or intraplaque hemorrhage in Chinese population remains unclear. This study uses carotid magnetic resonance imaging (\n CMRI<\/jats:styled-content>\n ) to investigate\n HRP<\/jats:styled-content>\n prevalence in carotid arteries of Chinese patients with cerebrovascular symptoms.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Patients with cerebral ischemic symptoms in the anterior circulation within 2\u00a0weeks and carotid plaque determined by ultrasound were recruited and underwent\n CMRI<\/jats:styled-content>\n . The\n HRP<\/jats:styled-content>\n features were identified and compared between symptomatic and asymptomatic arteries. Receiver\u2010operating\u2010characteristic analysis was used to calculate area\u2010under\u2010the\u2010curve (\n AUC<\/jats:styled-content>\n ) of stenosis and maximum wall thickness for discriminating presence of\n HRP<\/jats:styled-content>\n . In 1047 recruited subjects,\n HRP<\/jats:styled-content>\n detected by\n CMRI<\/jats:styled-content>\n was nearly 1.5 times more prevalent than severe stenosis (\u226550%) in this cohort (28% versus 19%,\n P<\/jats:italic>\n <0.0001). Approximately two thirds of\n HRP<\/jats:styled-content>\n s were found in arteries with <50% stenosis. The prevalence of\n HRP<\/jats:styled-content>\n in symptomatic carotid arteries was significantly higher than that of the contralateral asymptomatic carotid arteries (23.0% versus 16.4%,\n P<\/jats:italic>\n =0.001). Maximum wall thickness was found to be a stronger discriminator than stenosis for\n HRP<\/jats:styled-content>\n (\n AUC<\/jats:styled-content>\n : 0.93 versus 0.81,\n P<\/jats:italic>\n <0.0001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n There are significantly more high\u2010risk carotid plaques than carotid arteries with \u226550% stenosis in symptomatic Chinese patients. A substantial number of HRPs were found in arteries with lower grade stenosis and maximum wall thickness was a stronger indicator for HRP than luminal stenosis.<\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n URL<\/jats:styled-content>\n :\n https:\/\/www.clinicaltrials.gov\/<\/jats:ext-link>\n . Unique identifier:\n NCT<\/jats:styled-content>\n 02017756.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.005831","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T18:25:38Z","timestamp":1504290338000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":89,"title":["Prevalence and Characteristics of Carotid Artery High\u2010Risk Atherosclerotic Plaques in Chinese Patients With Cerebrovascular Symptoms: A Chinese Atherosclerosis Risk Evaluation II Study"],"prefix":"10.1161","volume":"6","author":[{"given":"Xihai","family":"Zhao","sequence":"first","affiliation":[{"name":"Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Hippe","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Washington, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gador M.","family":"Canton","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Washington, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Sui","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Tiantan Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Peking University First Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjing","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Radiology, Fujian Union Hospital, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Washington, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyofumi","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Washington, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas S.","family":"Hatsukami","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, University of Washington, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Washington, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoxue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Yuan","sequence":"additional","affiliation":[{"name":"Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China"},{"name":"Department of Radiology, University of Washington, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the CARE\u2010II Study 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