{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:44:47Z","timestamp":1791499487614,"version":"4.3.4"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,9,22]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Cardiovascular disease is the leading cause of mortality in postmenopausal women. Follicle\u2010stimulating hormone (\n              <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content>\n              ) shows negative associations with obesity and diabetes mellitus in postmenopausal women. We aimed to study the associations between\n              <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content>\n              and 10\u2010year risk of atherosclerotic cardiovascular disease (\n              <jats:styled-content style=\"fixed-case\">ASCVD<\/jats:styled-content>\n              ) in postmenopausal women.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">SPECT<\/jats:styled-content>\n              \u2010China (the Survey on Prevalence in East China for Metabolic Diseases and Risk Factors) is a 22\u2010site, population\u2010based study conducted during 2014\u20132015. This study included 2658 postmenopausal women. A newly developed effective tool for 10\u2010year\n              <jats:styled-content style=\"fixed-case\">ASCVD<\/jats:styled-content>\n              risk prediction among Chinese was adopted. Regression analyses were performed to assess the relationship among\n              <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content>\n              , 10\u2010year\n              <jats:styled-content style=\"fixed-case\">ASCVD<\/jats:styled-content>\n              risk, and multiple cardiometabolic risk factors. With the increase in\n              <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content>\n              quartiles, the mean 10\u2010year\n              <jats:styled-content style=\"fixed-case\">ASCVD<\/jats:styled-content>\n              risk in postmenopausal women decreased from 4.9% to 3.3%, and most metabolic parameters were significantly ameliorated (all\n              <jats:italic>P<\/jats:italic>\n              for trend &lt;0.05). In regression analyses, a 1\u2010\n              <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n              increment in ln\u2010\n              <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content>\n              was negatively associated with continuous (B\u00a0\u22120.12, 95% confidence interval, \u22120.16, \u22120.09,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05) and categorical (odds ratio 0.65, 95% confidence interval, 0.49, 0.85,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05) 10\u2010year\n              <jats:styled-content style=\"fixed-case\">ASCVD<\/jats:styled-content>\n              risk. These significant associations existed in subgroups with or without medication use, obesity, diabetes mellitus, hypertension, and dyslipidemia. Body mass index and waist circumference (both B \u22120.35, 95% confidence interval, \u22120.40, \u22120.30,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05) had the largest associations of all metabolic measures, and blood pressure had the smallest association.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Serum\n              <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content>\n              levels were negatively associated with 10\u2010year\n              <jats:styled-content style=\"fixed-case\">ASCVD<\/jats:styled-content>\n              risk in postmenopausal women. Among cardiometabolic factors, obesity indices had the largest associations with\n              <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content>\n              . These results indicated that a low\n              <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content>\n              might be a risk factor or a biomarker for cardiovascular disease risk in postmenopausal women.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.005918","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T00:10:38Z","timestamp":1504138238000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":74,"title":["Follicle\u2010Stimulating Hormone, Its Association with Cardiometabolic Risk Factors, and 10\u2010Year Risk of Cardiovascular Disease in Postmenopausal Women"],"prefix":"10.1161","volume":"6","author":[{"given":"Ningjian","family":"Wang","sequence":"first","affiliation":[{"name":"Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfang","family":"Shao","sequence":"additional","affiliation":[{"name":"Centre for Reproductive Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangzhen","family":"Xia","sequence":"additional","affiliation":[{"name":"Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chi","sequence":"additional","affiliation":[{"name":"Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Li","sequence":"additional","affiliation":[{"name":"Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Han","sequence":"additional","affiliation":[{"name":"Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yincheng","family":"Teng","sequence":"additional","affiliation":[{"name":"Centre for Reproductive Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 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