{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:50:07Z","timestamp":1792191007731,"version":"4.4.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,9,22]]},"abstract":"\n Background<\/jats:title>\n \n Wall shear stress (\n WSS<\/jats:styled-content>\n ) is a stimulus for vessel wall remodeling. Differences in ascending aorta (\n AA<\/jats:styled-content>\n o) hemodynamics have been reported between bicuspid aortic valve (\n BAV<\/jats:styled-content>\n ) and tricuspid aortic valve patients with aortic dilatation, but the confounding impact of aortic valve stenosis (\n AS<\/jats:styled-content>\n ) is unknown.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Five hundred seventy\u2010one subjects underwent 4\u2010dimensional flow magnetic resonance imaging in the thoracic aorta (210 right\u2010left BAV cusp fusions, 60 right\u2010noncoronary BAV cusp fusions, 245 tricuspid aortic valve patients with aortic dilatation, and 56 healthy controls). There were 166 of 515 (32%) patients with\n AS<\/jats:styled-content>\n .\n WSS<\/jats:styled-content>\n atlases were created to quantify group\u2010specific\n WSS<\/jats:styled-content>\n patterns in the\n AA<\/jats:styled-content>\n o as a function of\n AS<\/jats:styled-content>\n severity. In\n BAV<\/jats:styled-content>\n patients without\n AS<\/jats:styled-content>\n , the different cusp fusion phenotypes resulted in distinct differences in eccentric\n WSS<\/jats:styled-content>\n elevation: right\u2010left\n BAV<\/jats:styled-content>\n patients exhibited increased\n WSS<\/jats:styled-content>\n by 9% to 34% (\n P<\/jats:italic>\n <0.001) at the aortic root and along the entire outer curvature of the\n AA<\/jats:styled-content>\n o whereas right\u2010noncoronary\n BAV<\/jats:styled-content>\n patients showed 30%\n WSS<\/jats:styled-content>\n increase (\n P<\/jats:italic>\n <0.001) at the distal portion of the\n AA<\/jats:styled-content>\n o.\n WSS<\/jats:styled-content>\n in tricuspid aortic valve patients with aortic dilatation patients with no\n AS<\/jats:styled-content>\n was significantly reduced by 21% to 33% (\n P<\/jats:italic>\n <0.01) in 4 of 6\n AA<\/jats:styled-content>\n o regions. In all patient groups, mild, moderate, and severe\n AS<\/jats:styled-content>\n resulted in a marked increase in regional\n WSS<\/jats:styled-content>\n (\n P<\/jats:italic>\n <0.001). Moderate\u2010to\u2010severe\n AS<\/jats:styled-content>\n further increased\n WSS<\/jats:styled-content>\n magnitude and variability in the\n AA<\/jats:styled-content>\n o. Differences between valve phenotypes were no longer apparent.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n AS<\/jats:styled-content>\n significantly alters aortic hemodynamics and\n WSS<\/jats:styled-content>\n independent of aortic valve phenotype and over\u2010rides previously described flow patterns associated with\n BAV<\/jats:styled-content>\n and tricuspid aortic valve with aortic dilatation. Severity of\n AS<\/jats:styled-content>\n must be considered when investigating valve\u2010mediated aortopathy.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.005959","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T00:10:58Z","timestamp":1505347858000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":134,"title":["Aortic Valve Stenosis Alters Expression of Regional Aortic Wall Shear Stress: New Insights From a 4\u2010Dimensional Flow Magnetic Resonance Imaging Study of 571 Subjects"],"prefix":"10.1161","volume":"6","author":[{"given":"Pim","family":"van Ooij","sequence":"first","affiliation":[{"name":"Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands"},{"name":"Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Markl","sequence":"additional","affiliation":[{"name":"Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL"},{"name":"Department of Biomedical Engineering, Northwestern University, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy D.","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Carr","sequence":"additional","affiliation":[{"name":"Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Rigsby","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Ann & Robert H Lurie Children's Hospital of Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert O.","family":"Bonow","sequence":"additional","affiliation":[{"name":"Department of Medicine\u2010Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Chris","family":"Malaisrie","sequence":"additional","affiliation":[{"name":"Division of Surgery\u2010Cardiac Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick M.","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Division of Surgery\u2010Cardiac Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.M.","family":"Fedak","sequence":"additional","affiliation":[{"name":"Division of Surgery\u2010Cardiac Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL"},{"name":"Department of Cardiac Sciences, University of Calgary, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex J.","family":"Barker","sequence":"additional","affiliation":[{"name":"Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.972406"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1207059"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000027905.26586.E8"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1286"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.007851"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.112.973370"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.003026"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.06.1310"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezt610"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-14-84"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22485"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25224"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-014-1092-7"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24959"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2011.09.068"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000332"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-015-0174-5"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.01.039"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3181d4739e"},{"key":"e_1_3_4_21_2","unstructured":"Bock J Kreher BW Hennig J Markl M. Optimized pre\u2010processing of time\u2010resolved 2D and 3D phase contrast MRI data. Proceedings of the 15th Scientific Meeting of the International Society of Magnetic Resonance in Medicine. Wiley 2007:3138. Berlin Germany."},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22199"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25305"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000031"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.742486"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24560"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev228"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.11.007"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-012-0695-0"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-009-9854-3"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.09091437"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.113.000528"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-15-81"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2353-6"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25081"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9290(02)00441-4"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2016.02.019"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23735"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.117.005959","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:47:20Z","timestamp":1715597240000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.117.005959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,22]]},"references-count":37,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9,22]]}},"alternative-id":["10.1161\/JAHA.117.005959"],"URL":"https:\/\/doi.org\/10.1161\/jaha.117.005959","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,22]]},"assertion":[{"value":"2017-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e005959"}}