{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:52:18Z","timestamp":1790052738615,"version":"4.0.1"},"reference-count":57,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,11,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Cardiac hypertrophy increases the risk of developing heart failure and cardiovascular death. The neutrophil inflammatory protein, lipocalin\u20102 (\n              <jats:styled-content style=\"fixed-case\">LCN<\/jats:styled-content>\n              2\/\n              <jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content>\n              ), is elevated in certain forms of cardiac hypertrophy and acute heart failure. However, a specific role for\n              <jats:styled-content style=\"fixed-case\">LCN<\/jats:styled-content>\n              2 in predisposition and etiology of hypertrophy and the relevant genetic determinants are unclear. Here, we defined the role of\n              <jats:styled-content style=\"fixed-case\">LCN<\/jats:styled-content>\n              2 in concentric cardiac hypertrophy in terms of pathophysiology, inflammatory expression networks, and genomic determinants.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We used 3 experimental models: a polygenic model of cardiac hypertrophy and heart failure, a model of intrauterine growth restriction and\n              <jats:italic>Lcn2<\/jats:italic>\n              \u2010knockout mouse; cultured cardiomyocytes; and 2 human cohorts: 114 type 2 diabetes mellitus patients and 2064 healthy subjects of the YFS (Young Finns Study). In hypertrophic heart rats, cardiac and circulating\n              <jats:italic>Lcn2<\/jats:italic>\n              was significantly overexpressed before, during, and after development of cardiac hypertrophy and heart failure.\n              <jats:italic>Lcn2<\/jats:italic>\n              expression was increased in hypertrophic hearts in a model of intrauterine growth restriction, whereas\n              <jats:italic>Lcn2<\/jats:italic>\n              \u2010knockout mice had smaller hearts. In cultured cardiomyocytes,\n              <jats:italic>Lcn2<\/jats:italic>\n              activated molecular hypertrophic pathways and increased cell size, but reduced proliferation and cell numbers. Increased\n              <jats:styled-content style=\"fixed-case\">LCN<\/jats:styled-content>\n              2 was associated with cardiac hypertrophy and diastolic dysfunction in diabetes mellitus. In the\n              <jats:styled-content style=\"fixed-case\">YFS<\/jats:styled-content>\n              ,\n              <jats:italic>\n                <jats:styled-content style=\"fixed-case\">LCN<\/jats:styled-content>\n                2\n              <\/jats:italic>\n              expression was associated with body mass index and cardiac mass and with levels of inflammatory markers. The single\u2010nucleotide polymorphism, rs13297295, located near\n              <jats:italic>\n                <jats:styled-content style=\"fixed-case\">LCN<\/jats:styled-content>\n                2\n              <\/jats:italic>\n              defined a significant\n              <jats:italic>cis<\/jats:italic>\n              \u2010\n              <jats:styled-content style=\"fixed-case\">eQTL<\/jats:styled-content>\n              for\n              <jats:italic>\n                <jats:styled-content style=\"fixed-case\">LCN<\/jats:styled-content>\n                2\n              <\/jats:italic>\n              expression.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Direct effects of\n              <jats:styled-content style=\"fixed-case\">LCN<\/jats:styled-content>\n              2 on cardiomyocyte size and number and the consistent associations in experimental and human analyses reveal a central role for\n              <jats:styled-content style=\"fixed-case\">LCN<\/jats:styled-content>\n              2 in the ontogeny of cardiac hypertrophy and heart failure.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.005971","type":"journal-article","created":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T00:40:23Z","timestamp":1497487223000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":72,"title":["Experimental and Human Evidence for Lipocalin\u20102 (Neutrophil Gelatinase\u2010Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and Heart Failure"],"prefix":"10.1161","volume":"6","author":[{"given":"Francine Z.","family":"Marques","sequence":"first","affiliation":[{"name":"School of Applied and Biomedical Sciences, Faculty of Science and Technology, Federation University Australia, Ballarat, Victoria, Australia"},{"name":"Heart Failure Research Group, Baker Heart and Diabetes Research Institute, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla R.","family":"Prestes","sequence":"additional","affiliation":[{"name":"School of Applied and Biomedical Sciences, Faculty of Science and Technology, Federation University Australia, Ballarat, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean G.","family":"Byars","sequence":"additional","affiliation":[{"name":"Centre for Systems Genomics, The University of Melbourne, Victoria, Australia"},{"name":"School of BioSciences, The University of Melbourne, Victoria, Australia"},{"name":"Department of Pathology, The University of Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott C.","family":"Ritchie","sequence":"additional","affiliation":[{"name":"Centre for Systems Genomics, The University of Melbourne, Victoria, Australia"},{"name":"Department of Pathology, The University of Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"W\u00fcrtz","sequence":"additional","affiliation":[{"name":"Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila K.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Melbourne Austin Health, Heidelberg, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Booth","sequence":"additional","affiliation":[{"name":"School of Applied and Biomedical Sciences, Faculty of Science and Technology, Federation University Australia, Ballarat, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indrajeetsinh","family":"Rana","sequence":"additional","affiliation":[{"name":"School of Applied and Biomedical Sciences, Faculty of Science and Technology, Federation University Australia, Ballarat, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Minoda","sequence":"additional","affiliation":[{"name":"School of Applied and Biomedical Sciences, Faculty of Science and Technology, Federation University Australia, Ballarat, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart P.","family":"Berzins","sequence":"additional","affiliation":[{"name":"School of Applied and Biomedical Sciences, Faculty of Science and Technology, Federation University Australia, Ballarat, Victoria, Australia"},{"name":"Department of Microbiology and Immunology, Peter Doherty Institute, The University of Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire L.","family":"Curl","sequence":"additional","affiliation":[{"name":"Department of Physiology, The University of Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Physiology, The University of Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Wai","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Melbourne Austin Health, Heidelberg, Victoria, Australia"},{"name":"Department of Cardiology, Austin Health, Heidelberg, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyush M.","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Melbourne Austin Health, Heidelberg, Victoria, Australia"},{"name":"Department of Cardiology, Austin Health, Heidelberg, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti J.","family":"Kangas","sequence":"additional","affiliation":[{"name":"Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasi","family":"Soininen","sequence":"additional","affiliation":[{"name":"Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland"},{"name":"NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saku","family":"Ruohonen","sequence":"additional","affiliation":[{"name":"Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"K\u00e4h\u00f6nen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terho","family":"Lehtim\u00e4ki","sequence":"additional","affiliation":[{"name":"Fimlab Laboratories, Department of Clinical Chemistry, Pirkanmaa Hospital District, School of Medicine, University of Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Raitoharju","sequence":"additional","affiliation":[{"name":"Fimlab Laboratories, Department of Clinical Chemistry, Pirkanmaa Hospital District, School of Medicine, University of Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aki","family":"Havulinna","sequence":"additional","affiliation":[{"name":"National Institute for Health and Welfare, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Perola","sequence":"additional","affiliation":[{"name":"National Institute for Health and Welfare, Helsinki, Finland"},{"name":"Institute for Molecular Medicine Finland, University of Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli","family":"Raitakari","sequence":"additional","affiliation":[{"name":"Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland"},{"name":"Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veikko","family":"Salomaa","sequence":"additional","affiliation":[{"name":"National Institute for Health and Welfare, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Ala\u2010Korpela","sequence":"additional","affiliation":[{"name":"Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland"},{"name":"NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland"},{"name":"Medical Research Council Integrative Epidemiology Unit, University of Bristol, United Kingdom"},{"name":"School of Social and Community Medicine, University of Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Kettunen","sequence":"additional","affiliation":[{"name":"Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland"},{"name":"NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland"},{"name":"National Institute for Health and Welfare, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maree","family":"McGlynn","sequence":"additional","affiliation":[{"name":"School of Medicine, Deakin University, Waurn Ponds, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Kelly","sequence":"additional","affiliation":[{"name":"School of Applied and Biomedical Sciences, Faculty of Science and Technology, Federation University Australia, Ballarat, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Wlodek","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Melbourne Austin Health, Heidelberg, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Lewandowski","sequence":"additional","affiliation":[{"name":"School of Medicine, Deakin University, Waurn Ponds, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea M.","family":"Delbridge","sequence":"additional","affiliation":[{"name":"Department of Physiology, The University of Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise M.","family":"Burrell","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Melbourne Austin Health, Heidelberg, Victoria, Australia"},{"name":"Department of Cardiology, Austin Health, Heidelberg, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Inouye","sequence":"additional","affiliation":[{"name":"Heart Failure Research Group, Baker Heart and Diabetes Research Institute, Melbourne, Victoria, Australia"},{"name":"Centre for Systems Genomics, The University of Melbourne, Victoria, Australia"},{"name":"School of BioSciences, The University of Melbourne, Victoria, Australia"},{"name":"Department of Pathology, The University of Melbourne, Victoria, Australia"},{"name":"Department of Physiology, The University of Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"Harrap","sequence":"additional","affiliation":[{"name":"Department of Physiology, The University of Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi J.","family":"Charchar","sequence":"additional","affiliation":[{"name":"School of Applied and Biomedical Sciences, Faculty of Science and Technology, Federation University Australia, Ballarat, Victoria, Australia"},{"name":"Department of Physiology, The University of Melbourne, Victoria, Australia"},{"name":"Department of Cardiovascular Sciences, University of Leicester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199005313222203"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.008788"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.10.2764"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.093120"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.18.1477"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.03.009"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000058700.41738.12"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH06-11-0638"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.050706"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2010.02258.x"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2011.06.043"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000193567.88685.f4"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfr087"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.03.089"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00006.2002"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90919.2008"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028926"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007010015"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.153"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.248880"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20070261"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dym225"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2014.04.013"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001094"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001765"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/echo.13025"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.10.005"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-014-0561-9"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2013.09.013"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2014.232918"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2015.09.007"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(87)80168-0"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq871"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2016.06.012"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2011.409"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21209"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.5.538"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03104"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001000"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.863266"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0007"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00907.2011"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000207406.94146.c2"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90991-K"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00032.2006"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.20789"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20041392"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.075614"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2925"},{"key":"e_1_3_5_52_2","first-page":"129","article-title":"The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer","volume":"1826","author":"Chakraborty S","year":"2012","unstructured":"Chakraborty S, Kaur S, Guha S, Batra SK. The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer. Biochim Biophys Acta. 2012;1826:129\u2013169.","journal-title":"Biochim Biophys Acta"},{"key":"e_1_3_5_53_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20150075"},{"key":"e_1_3_5_54_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.05431"},{"key":"e_1_3_5_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.11.046"},{"key":"e_1_3_5_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.07.080"},{"key":"e_1_3_5_57_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.303718"},{"key":"e_1_3_5_58_2","doi-asserted-by":"publisher","DOI":"10.1159\/000016037"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.117.005971","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:32:38Z","timestamp":1715596358000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.117.005971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,6]]},"references-count":57,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,11,6]]}},"alternative-id":["10.1161\/JAHA.117.005971"],"URL":"https:\/\/doi.org\/10.1161\/jaha.117.005971","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,6]]},"assertion":[{"value":"2017-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e005971"}}