{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T07:18:43Z","timestamp":1758266323243,"version":"3.41.2"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,11,6]]},"abstract":"\n Background<\/jats:title>\n \n Early life risk factors are associated with cardiometabolic disease, but have not been fully studied in atrial fibrillation (\n AF<\/jats:styled-content>\n ). There are discordant results from existing studies of birth weight and\n AF<\/jats:styled-content>\n , and the impact of maternal body size, gestational age, placental size, and birth length is unknown.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n The Helsinki Birth Cohort Study includes 13\u00a0345 people born as singletons in Helsinki in the years 1934\u20131944. Follow\u2010up was through national registries, and ended on December 31, 2013, with 907 incident cases. Cox regression analyses stratified on year of birth were constructed for perinatal variables and incident\n AF<\/jats:styled-content>\n , adjusting for offspring sex, gestational age, and socioeconomic status at birth. There was a significant U\u2010shaped association between birth weight and\n AF<\/jats:styled-content>\n (\n P<\/jats:italic>\n for quadratic term=0.01). The lowest risk of\n AF<\/jats:styled-content>\n was found among those with a birth weight of 3.4\u00a0kg (3.8\u00a0kg for women [85th percentile] and 3.0\u00a0kg for men [17th percentile]). High maternal body mass index (\u226530\u00a0kg\/m\n 2<\/jats:sup>\n ) predicted offspring\n AF<\/jats:styled-content>\n ; hazard ratio 1.36 (95%\n CI<\/jats:styled-content>\n 1.07\u20131.74,\n P<\/jats:italic>\n =0.01) compared with normal body mass index (<25\u00a0kg\/m\n 2<\/jats:sup>\n ). Maternal height was associated with early\u2010onset\n AF<\/jats:styled-content>\n (<65.3\u00a0years), hazard ratio 1.47 (95%\n CI<\/jats:styled-content>\n 1.24\u20131.74,\n P<\/jats:italic>\n <0.0001), but not with later onset\n AF<\/jats:styled-content>\n . Results were independent of incident coronary artery disease, hypertension, or diabetes mellitus.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n High maternal body mass index during pregnancy and maternal height are previously undescribed predictors of offspring\n AF<\/jats:styled-content>\n . Efforts to prevent maternal obesity might reduce later\n AF<\/jats:styled-content>\n in offspring. Birth weight has a U\u2010shaped relation to incident\n AF<\/jats:styled-content>\n independent of other perinatal variables.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.006036","type":"journal-article","created":{"date-parts":[[2017,6,26]],"date-time":"2017-06-26T00:10:15Z","timestamp":1498435815000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Early Life Risk Factors for Incident Atrial Fibrillation in the Helsinki Birth Cohort Study"],"prefix":"10.1161","volume":"6","author":[{"given":"Linda S. B.","family":"Johnson","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Lund University Sk\u00e5ne University Hospital, Malm\u00f6, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minna","family":"Salonen","sequence":"additional","affiliation":[{"name":"Folkh\u00e4lsan Research Center, Helsinki, Finland"},{"name":"Department of Chronic Disease Prevention, National Institute of Health and Welfare, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eero","family":"Kajantie","sequence":"additional","affiliation":[{"name":"Department of Chronic Disease Prevention, National Institute of Health and Welfare, Helsinki, Finland"},{"name":"Children's Hospital, Helsinki University Hospital, University of Helsinki, Finland"},{"name":"PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Conen","sequence":"additional","affiliation":[{"name":"Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff S.","family":"Healey","sequence":"additional","affiliation":[{"name":"Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clive","family":"Osmond","sequence":"additional","affiliation":[{"name":"Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan G.","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Folkh\u00e4lsan Research Center, Helsinki, Finland"},{"name":"Department of Chronic Disease Prevention, National Institute of Health and Welfare, Helsinki, Finland"},{"name":"Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, 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