{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:01:30Z","timestamp":1789923690126,"version":"4.0.1"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2017,8,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Coronary artery disease is a leading killer of women. Arterial stiffness predicts myocardial infarction, and postmenopausal women have lower arterial compliance (\n              <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>\n              ) than men. We hypothesized that lower\n              <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>\n              would be associated with greater burden of coronary artery plaque and calcification, and that these associations would be stronger in women than men.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We evaluated 3639 consecutive adults without coronary artery disease history who had coronary computed tomography between 2006 and 2014. Coronary artery calcification was calculated using the Agatston method. Plaque extent was assessed by the number of arterial segments with visible plaque divided by the number of visualized segments \u00d7100 (percent plaque score). Indexed\n              <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>\n              was calculated as stroke volume index\/central pulse pressure. We used step\u2010wise multivariable linear regression to assess associations of log indexed\n              <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>\n              with log (percent plaque score+1) and log (coronary artery calcification+1). Sex\u2010specific models were performed if the interaction sex\u00d7\n              <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>\n              was significant. Mean age was 57\u00b111\u00a0years, 53% were men, and 71% were hypertensive. Interaction term sex\u00d7\n              <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>\n              was significant for both models (\n              <jats:italic>P<\/jats:italic>\n              =0.008 for percent plaque score and 0.022 for coronary artery calcification). Lower indexed\n              <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>\n              was associated with higher percent plaque score and coronary artery calcification in women (\u03b2\u00b1\n              <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\n              : \u22120.231\u00b10.113,\n              <jats:italic>P<\/jats:italic>\n              =0.042 and \u22120.334\u00b10.166,\n              <jats:italic>P<\/jats:italic>\n              =0.044, respectively), but not in men (\u03b2\u00b1\n              <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\n              : \u22120.062\u00b10.104,\n              <jats:italic>P<\/jats:italic>\n              =0.551 and 0.114\u00b10.173,\n              <jats:italic>P<\/jats:italic>\n              =0.510, respectively).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Lower\n              <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>\n              is associated with greater burden of coronary artery plaque and calcification in women, but not in men. Our findings highlight low\n              <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>\n              as a correlate of more\u2010advanced coronary artery disease and as a potential link to the worse cardiovascular outcomes in women.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.006079","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T18:25:38Z","timestamp":1504290338000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":39,"title":["Sex Differences in Associations of Arterial Compliance With Coronary Artery Plaque and Calcification Burden"],"prefix":"10.1161","volume":"6","author":[{"given":"Thais","family":"Coutinho","sequence":"first","affiliation":[{"name":"Division of Cardiac Prevention and Rehabilitation, University of Ottawa Heart Institute, Ottawa, Canada"},{"name":"Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeung","family":"Yam","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J.W.","family":"Chow","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girish","family":"Dwivedi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Harry Perkins Institute of Medical Research, Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"In\u00e1cio","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Ottawa, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","unstructured":"World Health Organization . 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